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HESI Critical Care Exam V1 V2 V3 2026: 300 Questions, Answers & Rationales | Next Generation NCLEX Practice

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Prepare for the HESI Critical Care Exam with this comprehensive 2026 edition practice test covering all three versions (V1, V2, V3). This document contains 300 realistic multiple‑choice questions with detailed rationales, aligned with Next Generation NCLEX (NGN) standards. Content domains include: Hemodynamics & Shock (septic, cardiogenic, hypovolemic, obstructive, neurogenic, anaphylactic), Respiratory Critical Care (ARDS, mechanical ventilation, chest tubes, tracheostomy, pneumothorax, status asthmaticus), Cardiovascular Critical Care (STEMI, heart failure, arrhythmias, IABP, LVAD, pericarditis, aortic dissection), Neurologic Critical Care (TBI, ICP management, subarachnoid hemorrhage, stroke, status epilepticus, Guillain‑Barré, spinal cord injury), Renal/Metabolic/Endocrine (AKI, DKA, HHS, thyroid storm, myxedema coma, adrenal crisis, SIADH, hypercalcemia), Multisystem & Sepsis (septic shock resuscitation, lactate, ScvO₂, procalcitonin, DIC), Gastrointestinal/Hepatic (variceal bleed, acute liver failure, pancreatitis, SBP, mesenteric ischemia), Hematology/Oncology Emergencies (febrile neutropenia, tumor lysis syndrome, DIC, sickle cell acute chest syndrome, HIT, ITP), Legal/Ethical/Professional Issues (brain death, advance directives, informed consent, error reporting, moral distress), plus maternal‑newborn, pediatric, and geriatric critical care topics. Each question includes a clear rationale to reinforce clinical judgment. Ideal for nursing students preparing for HESI specialty exams, critical care course finals, and NCLEX‑RN.

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HESI Critical Care V1 V2 V3 Exams
(PDF) | (2026) Exam Questions |
Nursing, Exams of Nursing

1. A client with septic shock has a BP of 78/45 mmHg after a 2 L fluid bolus. Which
vasopressor is first-line?

A) Norepinephrine

B) Dopamine

C) Phenylephrine

D) Epinephrine
Answer: A
Rationale: Surviving Sepsis Campaign: norepinephrine is first-line vasopressor in
septic shock.

2. A client with cardiogenic shock has a PAOP of 24 mmHg, CI 1.6 L/min/m², and
SVR 1400. Which medication is most appropriate?

A) Dobutamine

B) Norepinephrine

C) Furosemide

D) Nitroprusside
Answer: A
Rationale: Dobutamine increases contractility (low CI) and reduces afterload.

3. A client with a pulmonary artery catheter has a CVP of 2 mmHg. The nurse
should assess for?

A) Hypovolemia

B) Right ventricular failure

C) Cardiac tamponade

,D) Pulmonary hypertension
Answer: A
Rationale: Low CVP (<4-6 mmHg) indicates decreased preload (hypovolemia).

4. A client with a tension pneumothorax has tracheal deviation, absent breath
sounds, and hypotension. Which action is priority?

A) Needle decompression (2nd ICS, MCL)

B) Chest x-ray

C) Place a chest tube

D) Administer IV fluids
Answer: A
Rationale: Tension pneumothorax is a clinical diagnosis; needle decompression
before imaging.

5. A client on mechanical ventilation has a plateau pressure of 38 cm H₂O. Which
complication is most concerning?

A) Barotrauma

B) Hypovolemia

C) Hypercapnia

D) Pneumothorax
Answer: A
Rationale: Plateau pressure >30 cm H₂O increases risk of ventilator-induced lung
injury.

6. A client with ARDS has a PaO₂/FiO₂ ratio of 140. Which intervention improves
mortality?

A) Prone positioning

B) High tidal volume

C) Decreased PEEP

D) Sedation alone
Answer: A
Rationale: Prone positioning reduces mortality in moderate-severe ARDS (P/F
<150).

,7. A client with an arterial line has a dampened waveform. Which action should the
nurse take first?

A) Check for air bubbles or kinks; perform fast flush test

B) Zero the transducer

C) Replace the transducer

D) Document as normal
Answer: A
Rationale: Dampened waveform: troubleshoot system (air, clots, kinks) before
rezeroing.

8. A client in neurogenic shock (C5 spinal injury) has BP 70/40, HR 48, and warm
skin. Which intervention is priority?

A) Atropine and norepinephrine

B) IV fluids only

C) Dobutamine

D) Place in Trendelenburg
Answer: A
Rationale: Neurogenic shock: vasopressor + atropine/pacing for bradycardia.

9. A client with acute respiratory distress syndrome (ARDS) is on PEEP of 15 cm
H₂O. Which finding indicates a complication?

A) Blood pressure 85/50 mmHg

B) PaO₂ 85 mmHg

C) Urine output 50 mL/hour

D) Heart rate 80 bpm
Answer: A
Rationale: High PEEP decreases venous return → hypotension.

10. A client with a pulmonary embolism and hypotension receives thrombolytics.
Which complication is most serious?

A) Intracranial hemorrhage

B) Hemoptysis

C) Bruising

, D) Tachycardia
Answer: A
Rationale: Thrombolytics increase bleeding risk; intracranial hemorrhage is
life-threatening.

11. A client in hypovolemic shock has a CVP of 2 mmHg and BP 80/50. Which
intervention should the nurse implement first?

A) Administer IV fluid bolus

B) Start norepinephrine

C) Administer packed RBCs

D) Place in Trendelenburg
Answer: A
Rationale: Hypovolemic shock → fluid resuscitation first (crystalloid).

12. A client with an intra-aortic balloon pump (IABP) has a timing trigger set on
ECG. The balloon inflates at the T wave. Which adjustment is correct?

A) Inflate at dicrotic notch (end of systole)

B) Inflate at R wave

C) Deflate at T wave

D) No change
Answer: A
Rationale: IABP inflation at dicrotic notch increases coronary perfusion.

13. A client on mechanical ventilation has a high-pressure alarm. Which action
should the nurse take first?

A) Suction the patient

B) Sedate the patient

C) Disconnect the circuit

D) Notify respiratory therapy
Answer: A
Rationale: High pressure → likely mucus plug, biting, kink, or coughing; suction
first.

14. A client with a chest tube to water seal has continuous bubbling in the water
seal chamber. Which action is priority?

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