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Samenvatting Cel III: Hoofdstuk 6

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2025/2026 Written for academic year
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Universiteit Gent (UGent)
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Cel III: Energie en metabolisme
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Dit is een samenvatting van het zesde hoofdstuk van cel III voor 1ste bachelor tandheelkunde & geneeskunde (samen les) aan de UGent. Het bevat alle leerstof van de powerpoints en mijn notities van de lessen van Jan Gettemans. Met deze samenvatting heb ik een 18/20 gehaald, dus veel succes!

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Gluconeogenese
= vorming → glucose uit AZ, lactaat, pyruvaat, …
↳ invloed → bloedsuikerspiegel = regulatie ervan ANDERS hyper/hypo-glycemie
​ ↳ te veel glucose (niet opgenomen ⇒ insuline)? diabetes!
​ ↳ begin → diabetes? metformine ipv insuline ⇒ stopt gluconeogenese
↳ Waarom? hersenen & spierweefsel → brandstof nodig
↳ Waar? lever & niercortex
↳ gluconeogenese ≠ omgekeerde glycolyse MAAR WEL → deel
​ ↳ omgekeerde glycolyse → ΔG°’ = + DUS ≠ spontaan
⇒ gluconeogenese = gedeeltelijk → omgekeerde glycolyse
​ ↳ omkeerbare stappen W overgenomen
​ ↳ drie niet-omkeerbare stappen W vervangen

De drie nieuwe stappen
1)​ pyruvaat → fosfoënolpyruvaat
-​ pyruvaat → oxaalacetaat (anaplerotische reacties); mbv pyruvaat carboxylase
-​ oxaalacetaat → fosfoënolpyruvaat; mbv fosfoënolpyruvaat carboxykinase




2)​ fructose 1,6-bisfosfaat (+H2O) → fructose 6-fosfaat + Pi
-​ 1 fosfaatgroep weg = defosforylering; mbv fructose 1,6-bisfosfatase
-​ H2O gebruikt

3)​ glucose 6-fosfaat (+H2O) → glucose + Pi
-​ 1 fosfaatgroep weg = defosforylering; mbv glucose 6-fosfatase
-​ H2O gebruikt
⇒ glucose 6-fosfatase → lumer ER MAAR NIET hersen- & spiercellen DUS glucose
6-fosfaat W daar → glycolyse

⇒ heel proces → E nodig MAAR glucose → geeft nogsteeds meer E → einde

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  • tandheelkunde
  • geneeskunde
  • cel 3
  • ugent

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