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, 4/24/26, 7:26 PM Pharmacology: Respiratory Drugs Flashcards | Quizlet
Drugs for upper respiratory disorder: 1. antihistamines
2. decongestants
3. corticosteroids
4. antitussives
5. expectorants and myolytics
How do antihistamines work? Block the action of histamine at the H1 receptor
(H1 receptor release histamine are allergic response)
What are antihistamines used for? 1. Cold symptoms - decrease nasopharyngeal secretions
2. Allergic rhinitis - decrease nasal itching and tickling that cause sneezing
3. Anaphylaxis
4. Drug allergies
5. Blood/blood product transfusion reaction
6. Dermatologic conditions
7. Motion sickness, nausea, vomiting, and sedation
Prototype of antihistamine: diphenhydramine (Benadryl)
First-generation antihistamine (diphenhydramine, Dry mouth and drowsiness
Benadryl) cause:
What is a second-generation antihistamines? Cetirizine (Zyrtec)
Ioratadine (Claritin)
( Dont cause as much sedation as first-generation)
Benadryl does not make children excited. T/F False, it can make small children excitable
Benadryl can cause an allergic reaction. T/F True, especially in IM or IV
Benadryl is not used for nausea or motion sickness. T/F False, Benadryl is also used for nausea and motion sickness.
Astelin (nasal spray) has no systemic effects. True
What is nursing care for antihistamines? 1. Caution if driving vehicle or performing tasks due to drowsiness
2. Avoid alcohol and CNS depressants
3. Watch for confusion (not common), hypotension, dizziness, drowsiness, urinary
retention, blurred vision
4. Excitability in children
What is the mechanism of action of nasal and systemic stimulate adrenergic receptors to cause vascular constriction of the capillaries in the
decongestants? nasal mucosa
What is the results of a decongestant? Shrink nasal mucous membrane and reduce fluid secretions.
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