NUR-641E Midterm Exam Study Guide 1 - A Comprehensive Guide

NUR-641E Midterm Exam Study Guide 1 - A Comprehensive Guide - Understand what a prodrug is, and activation/inactivation by liver enzymes, and how it differs from active drugs. The liver is the principal site of drug metabolism. Although metabolism typically inactivates drugs, some drug metabolites are pharmacologically active—sometimes even more so than the parent compound. An inactive or weakly active substance that has an active metabolite is called a prodrug, especially if designed to deliver the active moiety more effectively. Know what Bioavailability (BA) a term used in pharmacology and nutritional and environmental sciences. In pharmacology, it refers to the degree and rate at which an administered drug is absorbed by the body's circulatory system, the systemic circulation. Bioavailability is an essential measurement tool since it determines the correct dosage for non-intravenous administration of a drug availability mean