06/04/2026, 23:50 med chem exam 2
Med Chem Exam 2 Complete Questions And
Verified Answers Update 2026 Set.
Statins are competitive inhibitors of 3-hydroxy-
How the cholesterol lowering drugs such as
3-methylglutaryl coenzyme A (HMG-CoA)
statins work? What is their target enzyme and
reductase, which catalyzes an early, rate-limiting
mechanism of action?
step in cholesterol biosynthesis.
What is the most important class of drug used
Nitrovasodilators/ Organic Nitrates
to treat angina/ angina pectoris?
All nitrovasodilator drugs are nitrate esters (C‒
O‒NO2 and characterized by a sequence of
Why all nitrovasodilator drugs are packed in
carbon‒oxygen‒nitrogen bond). Since the
dark bottles?
nitrate ester bond is highly susceptible to light
and moisture, they are packed in dark bottles.
Nitroglycerin or Glyceryl trinitrate
Which type of calcium channel is inhibited by
L-type or long-lasting calcium channels
the calcium channel blockers/antagonists?
Statins. Statins are competitive inhibitors of 3-
What are the most effective drugs for the
hydroxy-3-methylglutaryl coenzyme A (HMG-
reduction of LDL levels? What is their target
CoA) reductase, which catalyzes an early, rate-
protein (or which protein they inhibit)?
limiting step in cholesterol biosynthesis.
Norvasc ( amlodipine)
Norepinephrine (noradrenaline)
Name any two vasoconstrictors produced in our
Epinephrine (Adrenaline)
body.
Angiotensin II
1
, 06/04/2026, 23:50 med chem exam 2
What are the most important classes of drugs Diuretics
used to treat hypertension? Name any four
α-blockers
classes.
β-blockers
Angiotensin Converting Enzyme (ACE)
Angiotensin II Receptor Blockers (ARBs)
Nitrovasodilators
Ca2+ channel blockersQuestion
Why some statins like lovastatin and simvastatin
are less water soluble than other Because they are lactone prodrugs.
statins?
Name the organs responsible for the secretion/ Renin: Kidney
production of following proteins/ enzymes that Angiotensinogen: Liver
play a role in the regulation of blood pressure.
Angiotensin-converting enzyme: Lungs
enalapril or ACE Inhibitor
Name Angiotensin converting enzyme (ACE) catalyzes
Class the conversion of angiotensin-I to angiotensin-II
in lungs. Enalapril binds to ACE and inhibits
MOA production of angiotensin-II thereby reducing
hypertension.
Nitroglycerin or glyceryl trinitrate or
nitrovasodilators or organic nitrate
Name Nitrovasodilators are prodrugs and after oral
Class administration are absorbed. Upon absorption
these drugs are rapidly reduced to generate
MOA nitric oxide (NO). Nitric oxide causes
vasodilation by relaxing the vascular smooth
muscles.
Amlodipine or Norvasc or calcium channel
Name antagonists or calcium channel blockers
Class The calcium channel blockers bind to the α1
subunit of the L-type or long-lasting calcium
MOA channels present in the vascular smooth muscles
of the heart and blood vessel walls
2
Med Chem Exam 2 Complete Questions And
Verified Answers Update 2026 Set.
Statins are competitive inhibitors of 3-hydroxy-
How the cholesterol lowering drugs such as
3-methylglutaryl coenzyme A (HMG-CoA)
statins work? What is their target enzyme and
reductase, which catalyzes an early, rate-limiting
mechanism of action?
step in cholesterol biosynthesis.
What is the most important class of drug used
Nitrovasodilators/ Organic Nitrates
to treat angina/ angina pectoris?
All nitrovasodilator drugs are nitrate esters (C‒
O‒NO2 and characterized by a sequence of
Why all nitrovasodilator drugs are packed in
carbon‒oxygen‒nitrogen bond). Since the
dark bottles?
nitrate ester bond is highly susceptible to light
and moisture, they are packed in dark bottles.
Nitroglycerin or Glyceryl trinitrate
Which type of calcium channel is inhibited by
L-type or long-lasting calcium channels
the calcium channel blockers/antagonists?
Statins. Statins are competitive inhibitors of 3-
What are the most effective drugs for the
hydroxy-3-methylglutaryl coenzyme A (HMG-
reduction of LDL levels? What is their target
CoA) reductase, which catalyzes an early, rate-
protein (or which protein they inhibit)?
limiting step in cholesterol biosynthesis.
Norvasc ( amlodipine)
Norepinephrine (noradrenaline)
Name any two vasoconstrictors produced in our
Epinephrine (Adrenaline)
body.
Angiotensin II
1
, 06/04/2026, 23:50 med chem exam 2
What are the most important classes of drugs Diuretics
used to treat hypertension? Name any four
α-blockers
classes.
β-blockers
Angiotensin Converting Enzyme (ACE)
Angiotensin II Receptor Blockers (ARBs)
Nitrovasodilators
Ca2+ channel blockersQuestion
Why some statins like lovastatin and simvastatin
are less water soluble than other Because they are lactone prodrugs.
statins?
Name the organs responsible for the secretion/ Renin: Kidney
production of following proteins/ enzymes that Angiotensinogen: Liver
play a role in the regulation of blood pressure.
Angiotensin-converting enzyme: Lungs
enalapril or ACE Inhibitor
Name Angiotensin converting enzyme (ACE) catalyzes
Class the conversion of angiotensin-I to angiotensin-II
in lungs. Enalapril binds to ACE and inhibits
MOA production of angiotensin-II thereby reducing
hypertension.
Nitroglycerin or glyceryl trinitrate or
nitrovasodilators or organic nitrate
Name Nitrovasodilators are prodrugs and after oral
Class administration are absorbed. Upon absorption
these drugs are rapidly reduced to generate
MOA nitric oxide (NO). Nitric oxide causes
vasodilation by relaxing the vascular smooth
muscles.
Amlodipine or Norvasc or calcium channel
Name antagonists or calcium channel blockers
Class The calcium channel blockers bind to the α1
subunit of the L-type or long-lasting calcium
MOA channels present in the vascular smooth muscles
of the heart and blood vessel walls
2
