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NR 507 Midterm Exam 2026/2027 – Advanced
Pathophysiology | Latest Verified Questions &
Answers with Rationales | Chamberlain Nursing
Study Guide
1. A nurse is teaching about Type I hypersensitivity. Which statements accurately
describe Type I reactions? (Select all that apply.)
A. Mediated by IgE
B. Inflammation due to mast cell degranulation
C. Local symptoms: itching, rash
D. Systemic symptoms: wheezing
E. Most dangerous form: anaphylactic reaction with systemic hypotension and severe
bronchoconstriction
Correct Answer: A, B, C, D, E
Rationale: Type I hypersensitivity is mediated by IgE, involves mast cell degranulation,
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and causes local symptoms (itching, rash) and systemic symptoms (wheezing).
Anaphylaxis is the most dangerous form with hypotension and bronchoconstriction.
2. A nurse is teaching about the treatment for anaphylaxis. What is the main
treatment for anaphylactic reactions?
A. Antihistamines
B. Corticosteroids
C. Epinephrine
D. Bronchodilators
Correct Answer: C
Rationale: Epinephrine is the first-line treatment for anaphylaxis, reversing
bronchoconstriction, hypotension, and vasodilation.
3. A nurse is teaching about Type II hypersensitivity. Which statements accurately
describe Type II reactions? (Select all that apply.)
A. Cytotoxic, tissue-specific
B. Primary effector cells: macrophages
C. Can cause tissue damage or alter function
D. Example: Graves' disease (alters thyroid function)
E. Example: Incompatible blood type (cell/tissue damage)
Correct Answer:A, B, C, D, E
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Rationale: Type II hypersensitivity is cytotoxic and tissue-specific, mediated by
macrophages. It can cause tissue damage (transfusion reaction) or altered function
(Graves' disease).
4. A nurse is differentiating between Type II and Type III hypersensitivity. Which
statement accurately describes the difference?
A. Type II is organ-specific (antibody binds to antigen on cell surface); Type III is not
organ-specific (antibody binds to soluble antigen outside cell, complexes deposit in
tissues)
B. Type II is mediated by IgE; Type III is mediated by T cells
C. Type II causes delayed reaction; Type III causes immediate reaction
D. Type II involves mast cells; Type III involves macrophages
Correct Answer: A
Rationale: Type II is organ-specific with antibody binding to cell surface antigens. Type
III involves soluble antigens; immune complexes form in circulation and deposit in
various tissues.
5. A nurse is teaching about Type III hypersensitivity. Which are examples of Type III
reactions? (Select all that apply.)
A. Rheumatoid arthritis
B. Systemic lupus erythematosus (SLE)
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C. Graves' disease
D. Allergic rhinitis
E. Contact dermatitis
Correct Answer: A, B
Rationale: Rheumatoid arthritis and SLE are Type III hypersensitivity reactions involving
immune complex deposition in joints and organs. Graves' disease is Type II, allergic
rhinitis is Type I, and contact dermatitis is Type IV.
6. A nurse is assessing a patient with systemic lupus erythematosus (SLE). Which
manifestations are associated with SLE? (Select all that apply.)
A. Malar rash (confined to cheeks)
B. Discoid rash (raised, patchy, scaly)
C. Photosensitivity
D. Oral/nasopharyngeal ulcers
E. Non-erosive arthritis
F. Renal disorder (proteinuria)
G. Neurologic disorders (seizures)
Correct Answer:A, B, C, D, E, F, G
Rationale: SLE is a Type III autoimmune disease with diverse manifestations including
NR 507 Midterm Exam 2026/2027 – Advanced
Pathophysiology | Latest Verified Questions &
Answers with Rationales | Chamberlain Nursing
Study Guide
1. A nurse is teaching about Type I hypersensitivity. Which statements accurately
describe Type I reactions? (Select all that apply.)
A. Mediated by IgE
B. Inflammation due to mast cell degranulation
C. Local symptoms: itching, rash
D. Systemic symptoms: wheezing
E. Most dangerous form: anaphylactic reaction with systemic hypotension and severe
bronchoconstriction
Correct Answer: A, B, C, D, E
Rationale: Type I hypersensitivity is mediated by IgE, involves mast cell degranulation,
,2|Page
and causes local symptoms (itching, rash) and systemic symptoms (wheezing).
Anaphylaxis is the most dangerous form with hypotension and bronchoconstriction.
2. A nurse is teaching about the treatment for anaphylaxis. What is the main
treatment for anaphylactic reactions?
A. Antihistamines
B. Corticosteroids
C. Epinephrine
D. Bronchodilators
Correct Answer: C
Rationale: Epinephrine is the first-line treatment for anaphylaxis, reversing
bronchoconstriction, hypotension, and vasodilation.
3. A nurse is teaching about Type II hypersensitivity. Which statements accurately
describe Type II reactions? (Select all that apply.)
A. Cytotoxic, tissue-specific
B. Primary effector cells: macrophages
C. Can cause tissue damage or alter function
D. Example: Graves' disease (alters thyroid function)
E. Example: Incompatible blood type (cell/tissue damage)
Correct Answer:A, B, C, D, E
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Rationale: Type II hypersensitivity is cytotoxic and tissue-specific, mediated by
macrophages. It can cause tissue damage (transfusion reaction) or altered function
(Graves' disease).
4. A nurse is differentiating between Type II and Type III hypersensitivity. Which
statement accurately describes the difference?
A. Type II is organ-specific (antibody binds to antigen on cell surface); Type III is not
organ-specific (antibody binds to soluble antigen outside cell, complexes deposit in
tissues)
B. Type II is mediated by IgE; Type III is mediated by T cells
C. Type II causes delayed reaction; Type III causes immediate reaction
D. Type II involves mast cells; Type III involves macrophages
Correct Answer: A
Rationale: Type II is organ-specific with antibody binding to cell surface antigens. Type
III involves soluble antigens; immune complexes form in circulation and deposit in
various tissues.
5. A nurse is teaching about Type III hypersensitivity. Which are examples of Type III
reactions? (Select all that apply.)
A. Rheumatoid arthritis
B. Systemic lupus erythematosus (SLE)
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C. Graves' disease
D. Allergic rhinitis
E. Contact dermatitis
Correct Answer: A, B
Rationale: Rheumatoid arthritis and SLE are Type III hypersensitivity reactions involving
immune complex deposition in joints and organs. Graves' disease is Type II, allergic
rhinitis is Type I, and contact dermatitis is Type IV.
6. A nurse is assessing a patient with systemic lupus erythematosus (SLE). Which
manifestations are associated with SLE? (Select all that apply.)
A. Malar rash (confined to cheeks)
B. Discoid rash (raised, patchy, scaly)
C. Photosensitivity
D. Oral/nasopharyngeal ulcers
E. Non-erosive arthritis
F. Renal disorder (proteinuria)
G. Neurologic disorders (seizures)
Correct Answer:A, B, C, D, E, F, G
Rationale: SLE is a Type III autoimmune disease with diverse manifestations including
