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1. Which of the following white blood cells types are elevated in parasitic infec-
tions, hypersensitivity reactions and autoimmune disorders?
1. Neutrophils
2. Eosinophils
3. Basophils
4 Monocytes: 2. Eosinophils
2. Mrs. Jameson complains of unilateral blurry vision and partial blindness in the
left eye. On physical examination, you find decreased peripheral vision on her
left side. Funduscopic examination reveals cotton wool spots. Your most likely
diagnosis is:
1. cryptococcosis
2. toxoplasmosis
3. Cytomegalovirus infection
4. Herpes simplex virus infection: 3. Cytomegalovirus infection
The classic signs and symptoms of cytomegalovirus infection on funduscopic examination include cotton wool spots,
a "cottage cheese and ketchup" appearance, hemorrhage, and exudates. Decreased peripheral vision, blurriness, and
partial blindness are other clinical manifestations. Referral to an ophthalmologist is imperative.
3. Your client Mrs. Young, age 64, is here to see you because she has pain in
her left breast. She reports no pain in her right breast and no noted lesions or
masses on breast self-exam, which she performs monthly. You know that:
1. At her age, you do not need to worry about breast cancer.
2. Initial presentation of breast pain is usually not suspicious for malignancy.
3. She must be sent for a mammogram as soon as possible
4. she has no personal history of breast cancer; therefore you are not con-
cerned: 3. She must be sent for a mammogram ASAP
In postmenopausal women, pain in one breast is highly suggestive of a malignant process despite past personal and/or
family history. Additionally, you know that age 64 puts this client at a high risk of breast cancer. You must send her for
a mammogram as soon as possible even if she had a negative one less than a year before.
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4. When the donor and recipient of a transplant are identical twins, this is
referred to as what type of transplant?
1. isograft
2. autograft
3. allograft
4. xenograft: An isograft is a transplant in which the donor and recipient are identical twins.
5. Frank, a 66-year-old white male who is on diuretic therapy, presents with
an elevated hematocrit. He also has splenomegaly on examination as well as
subjective complaints of blurred vision, fatigue, headache, and tinnitus. You
suspect:
1. Multiple myeloma
2. Waldenstrom macroglobulinemia
3. dehydration related to the use of diuretics
4. polycythemia vera: 4. Polycythemia vera
An elevated hematocrit due to contracted plasma volume, rather than increased red blood cell mass, may be due to
diuretic use or may occur without obvious cause. However, the associated signs and symptoms of splenomegaly, blurred
vision, fatigue, headache, and tinnitus lead you to suspect polycythemia vera. An elevated hematocrit due to contracted
plasma volume is often called spurious polycythemia, and a number of conditions, such as hypoxia and high-altitude
exposure, can cause a secondary polycythemia, but splenomegaly is absent in these cases. Primary polycythemia vera
is an acquired myeloproliferative disorder that causes an overproduction of all 3 hematopoietic cell lines.
6. Your client Mr. Jones has Sjögren syndrome. Which treatment do you sug-
gest?
1. artificial tears and chewing sugarless gum
2. frequent rinsing of the mouth with mouthwash
3. drinking at least 1 glass of milk per day
4. removing wax from the ears at regular intervals: 1. Artificial tears and chewing sugarless
gum.
Sjögren syndrome is a multisystem autoimmune disease characterized by dysfunction of the exocrine glands; it is
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specifically notable for dry eyes and dry mouth. Treatment is aimed at increasing comfort and lubrication. Artificial tears
can be self-administered as needed; preservative-free products are usually better tolerated. For dry mouth, increasing
hydration and chewing sugarless gum may be helpful. Oral pilocarpine (Salagen) 5 mg 4 times a day and cevimeline
(Evoxac) 30 mg 3 times a day have been shown to increase saliva production.
7. Mandy's 16-year-old daughter has hepatitis A. Which of the following state-
ments made by Mandy indicates she understands the teaching you've just
completed?
1. "I guess she needs to be hospitalized until she's recovered"
2. " we'll keep her at home with strict isolation precautions"
3. "we'll stop at the store and buy plastic eating utensils"
4. we'll stop at the drug store and pick up prescription medications immediate-
ly": 3. We'll stop at the store and buy plastic eating utensils
Clients with hepatitis A should have their eating and drinking utensils kept separate, or they should use disposable
ones.
8. You are examining Joseph, age 9 months, and note a palpable right supra-
clavicular lymph node. You know that this finding is suspicious for:
1. candidiasis
2. cryptococcosis
3. lymphoma of the mediastinum
4. abdominal malignancy: 3. lymphoma of the mediastinum
Palpable supraclavicular lymph nodes are not normal in infants, children, or adults. A palpable right-sided node is more
commonly associated with lymphoma of the mediastinum.
9. Which of the following cancers is associated with Epstein-Barr virus?
1. burkitt lymphoma
2. kaposi sarcoma
3. lymphoma
4. adult t-cell leukemia: 1. burkitt lymphoma
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10. Your client Shirley has an elevated mean corpuscular volume (MCV). What
should you be considering in terms of diagnosis?
1. iron deficiency anemias
2. hemolytic anemias
3. lead poisoning
4. liver disease: 4 liver disease
MCV indicates the average size of individual red blood cells (RBCs). The normal (normocytic) range is 76 to 96 fL. MCV
is increased (macrocytic) in megaloblastic anemias (ie, vitamin B12 deficiency and folate deficiency) and liver disease
(such as that resulting from alcohol abuse) as well as with the use of some drugs (eg, zidovudine).
11. A 28-year-old female presents to your primary care office for an annual
physical. She denies any complaints other than heavy menstrual bleeding,
which is something she has experienced her whole life. On routine complete
blood count (CBC) evaluation, her hemoglobin is 11.0. Other pertinent values
include a decreased serum ferritin and elevated total iron-binding capacity
(TIBC). Her mean corpuscular volume (MCV) is 75. Which of the following is the
likely cause of her anemia?
1. iron deficiency anemia
2. thalassemia
3. sideroblastic anemia
4. anemia of chronic disease (ACD): 1. iron deficiency anemia
This patient's lab values point toward microcytic anemia. With low iron stores and high ability to bind iron, iron deficiency
anemia is the best choice.
12. Which of the following is the most common cause of megaloblastic anemia?
1. vitamin B12 deficiency
2. pernicious anemia
3. latrogensis
4. folate deficiency: 2. pernicious anemia