NCLEX Practice Questions 2026: Case
Studies with Answers & Detailed
Rationales
1. Treatment modalities for estrogen-receptor positive tumors
include (select all that apply):
A. Estrogen-receptor downregulators (ERDs)
B. Selective estrogen-receptor response modulators (SERMs)
C. Hormone therapy
D. Aromatase inhibitors - answer-A, B, D
2. Stage IIIB describes invasive breast cancer in which:
A. The tumor measures up to 2 cm and has not spread outside
the breast
B. No tumor is found in the breast
C. Cancer may have spread to up to 9 axillary lymph nodes
causing swelling
D. The cancer has metastasized to other organs - answer-C.
Cancer may have spread to up to 9 axillary lymph nodes
causing swelling
,3. In stage IIIB carcinoma of the breast the cancer may have spread
to up to 9 axillary lymph nodes. Ms. T has 8 of 12 lymph nodes
affected. Answers A or B may occur in stage I, and answer choice
D describes stage IV
4. 3.Which of the following are important interventions when caring
for a patient with Cushing syndrome? (Select all that apply)
A. Increase carbohydrate intake
B. Monitoring blood glucose levels
C. Observing for signs of hypotension
D. Protecting patient from exposure to infection - answer-B, D
5. Hyperglycemia occurs with Cushing disease because of glucose
intolerance (associated with cortisol-induced insulin resistance)
and increased gluconeogenesis by the liver. High levels of
corticosteroids increase susceptibility to infection and delay
wound healing.
6. In a 29-year-old female client who is being successfully treated for
Cushing's syndrome, nurse Lyzette would expect a decline in:
A. Menstrual flow
B. Bone mineralization
C. Hair loss
D. Serum glucose level - answer-D. Serum glucose level
, 7. Serum glucose levels tend to be high in patients with Cushing's
Syndrome due to excess corticosteroids in the body. When
Cushing's syndrome is being treated successfully, a nurse should
expect a decline in the patient's serum glucose level
8. Mr. A has been admitted to the hospital with a diagnosis of acute
pancreatitis and the nurse is assessing his pain. What type of pain
is associated with this diagnosis?
A. Burning and aching, located in the left lower quadrant and
radiating to the leg
B. Severe and unrelenting, located in the epigastric area and
radiating to the back
C. Burning and aching, located in the epigastric area and
radiating to the umbilicus
D. Severe and unrelenting, located in the left lower quadrant
and radiating to the hip - answer-B. Severe and unrelenting,
located in the epigastric area and radiating to the back
9. The pain associated with acute pancreatitis is often severe and
unrelenting, is located in the epigastric region, and radiates to the
back. It is also described as sudden onset, deep piercing,
continuous or steady. The other options are incorrect.
10. The nurse is reviewing the prescription for Mr. A., a 55 year-
old male admitted to the hospital with a diagnosis of acute
Studies with Answers & Detailed
Rationales
1. Treatment modalities for estrogen-receptor positive tumors
include (select all that apply):
A. Estrogen-receptor downregulators (ERDs)
B. Selective estrogen-receptor response modulators (SERMs)
C. Hormone therapy
D. Aromatase inhibitors - answer-A, B, D
2. Stage IIIB describes invasive breast cancer in which:
A. The tumor measures up to 2 cm and has not spread outside
the breast
B. No tumor is found in the breast
C. Cancer may have spread to up to 9 axillary lymph nodes
causing swelling
D. The cancer has metastasized to other organs - answer-C.
Cancer may have spread to up to 9 axillary lymph nodes
causing swelling
,3. In stage IIIB carcinoma of the breast the cancer may have spread
to up to 9 axillary lymph nodes. Ms. T has 8 of 12 lymph nodes
affected. Answers A or B may occur in stage I, and answer choice
D describes stage IV
4. 3.Which of the following are important interventions when caring
for a patient with Cushing syndrome? (Select all that apply)
A. Increase carbohydrate intake
B. Monitoring blood glucose levels
C. Observing for signs of hypotension
D. Protecting patient from exposure to infection - answer-B, D
5. Hyperglycemia occurs with Cushing disease because of glucose
intolerance (associated with cortisol-induced insulin resistance)
and increased gluconeogenesis by the liver. High levels of
corticosteroids increase susceptibility to infection and delay
wound healing.
6. In a 29-year-old female client who is being successfully treated for
Cushing's syndrome, nurse Lyzette would expect a decline in:
A. Menstrual flow
B. Bone mineralization
C. Hair loss
D. Serum glucose level - answer-D. Serum glucose level
, 7. Serum glucose levels tend to be high in patients with Cushing's
Syndrome due to excess corticosteroids in the body. When
Cushing's syndrome is being treated successfully, a nurse should
expect a decline in the patient's serum glucose level
8. Mr. A has been admitted to the hospital with a diagnosis of acute
pancreatitis and the nurse is assessing his pain. What type of pain
is associated with this diagnosis?
A. Burning and aching, located in the left lower quadrant and
radiating to the leg
B. Severe and unrelenting, located in the epigastric area and
radiating to the back
C. Burning and aching, located in the epigastric area and
radiating to the umbilicus
D. Severe and unrelenting, located in the left lower quadrant
and radiating to the hip - answer-B. Severe and unrelenting,
located in the epigastric area and radiating to the back
9. The pain associated with acute pancreatitis is often severe and
unrelenting, is located in the epigastric region, and radiates to the
back. It is also described as sudden onset, deep piercing,
continuous or steady. The other options are incorrect.
10. The nurse is reviewing the prescription for Mr. A., a 55 year-
old male admitted to the hospital with a diagnosis of acute
