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Comprehensive CNS Medications Study Guide 2026/2027 | Stimulants, Antidementia, Anxiety, Sedatives, Antidepressants & Antipsychotics | Verified Nursing Exam Reference

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Master CNS pharmacology with this Comprehensive Study Guide covering stimulants, antidementia drugs, anxiety, sedatives, antidepressants, and antipsychotics. Updated for 2026/2027, this guide includes verified nursing exam reference material, detailed mechanisms, classifications, and clinical applications for effective exam prep and practical practice.

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Common Medications by Class

CNS Stimulants

CNS stimulants are primarily used to treat attention
deficit hyperactivity disorder (ADHD) and narcolepsy.
They increase levels of certain neurotransmitters in the
brain, enhancing focus and alertness.
Amphetamines: Include medications like Adderall XR
and Vyvanse, which are effective in managing ADHD
symptoms by increasing dopamine and norepinephrine
levels.
Methylphenidate: Commonly known as Ritalin and
Concerta, it works similarly to amphetamines but has a
different chemical structure.
Analeptics: Such as Armodafinil and Modafinil, are
used to treat sleep disorders and enhance wakefulness.
Anorexiants: Medications like Phentermine are used for
weight loss by suppressing appetite.
Miscellaneous Drugs: Atomoxetine is a non-stimulant
option for ADHD, while Clonidine and Guanfacine are
used for ADHD and other conditions.

Antidementia Medications

Antidementia medications are primarily used to treat
symptoms of Alzheimer's disease and other dementias.
Cholinesterase Inhibitors: Donepezil and Rivastigmine
work by increasing levels of acetylcholine, a
neurotransmitter associated with memory and learning.
NMDA Receptor Antagonist: Memantine helps to
regulate glutamate activity, which can be neurotoxic in
excess, thus protecting brain cells.
Combination Medication: Memantine/donepezil
(Namzaric) combines the effects of both drug classes for
enhanced efficacy.
These medications do not cure dementia but can help
manage symptoms and improve quality of life.

, Clinical trials have shown varying degrees of
effectiveness, with some patients experiencing
significant benefits.

Antianxiety Medications

Antianxiety medications are used to treat anxiety
disorders and related conditions.
Benzodiazepines: Include Alprazolam and Diazepam,
which enhance the effect of the neurotransmitter GABA,
leading to sedation and reduced anxiety.
Nonbenzodiazepines: Buspirone is a non-sedative
option that works differently than benzodiazepines,
often used for chronic anxiety.
Benzodiazepine Antidote: Flumazenil is used in cases
of benzodiazepine overdose to reverse sedation effects.
These medications can be habit-forming, and long-term
use is generally discouraged due to potential
dependency.
Cognitive-behavioral therapy (CBT) is often
recommended in conjunction with medication for
optimal treatment.

Sedatives and Hypnotics

Sedatives and hypnotics are used to induce sleep and
manage insomnia.
Benzodiazepines: Temazepam and Triazolam are
commonly prescribed for short-term management of
sleep disorders.
Nonbenzodiazepines: Medications like Zolpidem and
Eszopiclone are preferred for their lower risk of
dependency and side effects.
Barbiturates: Rarely used today due to safety concerns,
but Pentobarbital is an example of a barbiturate that was
historically used for sedation.
These medications should be used with caution, as they
can lead to tolerance and withdrawal symptoms.
Non-pharmacological approaches, such as sleep hygiene
education, are recommended as first-line treatments.

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