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Describe how to determine the probability of clinical outcomes
given information
about the parents (eg two heterozygous carriers of sickle
cell disease) -
ANSWER -in two heterozygous (two different gene sets) carriers
(one dominant
and one recessive gene) creates a 50% chance outcome of
offspring having
sickle cell
disease
Describe how calcitonin, parathyroid hormone, and calcitriol
(Vitamin D) work together to maintain normal blood calcium
levels. - ANSWER -calcitonin and PTH work oppositely to
balance calcium. the three work together to shift calcium into
bones, organs and blood
Describe the function of osteocytes within lacunae of bone -
ANSWER Osteocytes maintain bone mass through anabolic
activities; they promote bone repair through recruitment of
osteoclast mediated turnover
,Describe bone remodeling. Which cells are involved in this
process and what is their function? - ANSWER -osteoclasts
destroy old, degenerative cells to make room for new ones.
osteoblasts build new bone cells. osteocytes facilitate this
process and help retain calcium for bone strength and health.
Describe the process of articular degeneration. Which cells are
involved in this process and what is their function? - ANSWER -
articular degeneration is also known as osteoarthritis.
macrophages are the primary cell involved, and they induce
inflammation.
How does denosumab treat osteoporosis? - ANSWER -
Denosumab is an antibody that slows down the natural rate
your bones are broken down. It works by blocking a protein and
suppressing the cells that break down bone.
How does compartment syndrome develop? Which part of our
body tends to develop compartment syndrome? How do
patients typically recognize they may need to seek medical
assistance for rhabdomyolysis? What is the most sensitive
laboratory test for rhabdomyolosis? - ANSWER -Compartment
syndrome occurs when blood flow is restricted to area for an
extended period of time. It usually develops in extremities.
Patients recognize rhabdo by new muscle pain and decreased
urinary output, and is detected by creatine kinase in the blood.
What is a pulmonary embolism? What is a fat embolism? When
might a patient develop a pulmonary embolism? When might a
, patient develop a fat embolism? How are they treated? -
ANSWER -Pulmonary embolism is when a blood clot is lodge in
a pulmonary artery, usually caused by a traveling clot getting
lodged. A fat embolism is when a clot of fat cells disrupts blood
flow, usually after a bone fracture. PEs are treated with
anticoagulants to thin the blood, while there is no specific
treatment for FEs.
Describe Albinism. What portions of the body are negatively
affected by Albinism? - ANSWER -It is an alteration in a gene
that has decreased pigment to skin, hair, and eyes.
Describe how retinal detachment leads to vision loss. -
ANSWER -The areas where the retina detaches lose their blood
supply and stop working, causing you to lose vision.
Name two biomarkers that can be used to confirm a myocardial
infarction occurred and what types of molecules are they? -
ANSWER -troponin, creatine kinase
What is lymph - ANSWER -fluid that flows in lymphatic
system to return fluid
from tissues into
circulation
What are lymph nodes? - ANSWER -Filter interstitial fluid.
Swollen glands mean
you are fighting an
infection