TESTBANKFORMODERNBLOODBANKING&
TRANSFUSIONPRACTICES7THEDITIONBY
DENISEMHARMENING
9780803668881CHAPTER1-29COMPLETE
GUIDE
,https://www.stuvia.com/
Chapter 1 RBCs and Platelet Preservation: Historical Perspectives and Current Trends
sw sw sw sw sw sw sw sw sw sw
Multiple Choice sw
Identify the choice that best completes the statement or answers the question.
sw sw sw sw sw sw sw sw sw sw sw
1. Which metabolic pathway is responsible for generating 90% of the ATP for the RBC?
sw sw sw sw sw sw sw sw sw sw sw sw sw
a. Pentose phosphate shunt c. Glycolysis sw sw
b. Luebering-Rapoport shunt d. Methemoglobin reductase sw s w sw
2. A unit of blood was returned to the blood bank before it was spiked. Apparently the patient’s IV failed. The
sw sw sw sw sw sw sw sw sw sw sw sw sw sw sw sw sw sw sw sw
unit of blood was outside the blood bank for 35 minutes. Which of the statements below is most a ccurate?
sw sw sw sw sw sw sw sw sw sw sw sw sw sw sw sw sw s w sw
a. The unit of blood should be discarded immediately. sw sw sw sw sw sw sw
b. The unit of blood can be returned to inventory. sw sw sw sw sw sw sw sw
c. The unit of blood must be transfused within 4 hours or be discarded at the end of that time.
sw sw sw sw s w sw sw sw sw sw sw sw sw sw sw sw sw sw
d. The unit of blood must be transfused with 24 hours. sw sw sw sw sw sw sw sw sw
3. What is the average diameter of a platelet?
sw sw sw sw s w sw sw
a. 5 to 10 µm s w s w sw c. 1 to 2 µm sw s w sw
b. 2 to 4 µm s w s w sw d. 4 to 6 µm sw sw sw
4. In the normal hemoglobin-
sw sw sw
oxygen dissociation curve, what percentage of oxygen is releasedKto the tissuesKwhen PO2 averages 4
sw sw sw sw sw sw sw sw sw sw sw s w sw s
0 mm Hg? w sw sw
a. 75% c. 100%
b. 25% d. 50% s w s w
5. What factors are known to influence platelet metabolism and function?
sw sw sw sw sw sw sw sw sw
a. Storage temperature c. Platelet count sw sw
b. Initial pH d. All of theKabove sw s w sw sw
6. Which of the following red blood cellKmorphologies mayKbeKpresent on the peripheral blood smear as a re sult
sw sw sw sw sw sw sw sw sw sw sw sw sw sw sw sw
of loss of RBC membrane?
sw sw sw sw sw
a. Spherocytes c. Burr cells sw
b. Target cells d. Schistocytes sw s w
7. What does the term autologous transfusionKrefer to?
sw sw sw sw sw sw
a. A parent donating blood for his orKher child
sw sw sw sw sw sw sw
b. An individualKdonating bloodKfor a friend sw sw sw sw
c. An individualKdonating blood forKa relative sw sw sw sw
d. AnKindividual donating bloodKfor his or her own transfusion sw sw sw sw sw sw sw
8. What is theKprimary functionKof hemoglobin?
sw sw sw sw
a. Iron metabolism c. Oxygen transport
sw sw
b. Porphyrin synthesis d. Signal transduction sw s w s w
9. All of the followingKareas of red blood cell biology are crucial for normal erythrocyte survival except:
sw sw sw sw sw sw sw sw sw sw sw sw sw sw s w
a. Cellular metabolism. c. Site of the ABO antigen attachment.
sw sw sw sw sw sw
b. RBC membrane. d. Hemoglobin structure.
sw s w sw
This study source was downloaded by 100000826342158 from CourseHero.com on 09-15-
sw s w s w s w s w s w s w s w s w s w
2021 17:54:15 GMT -
s w s w s w
https://www.coursehero.com/file/25537437/ch01rtf/
,https://www.stuvia.com/
sw 10. What is the correct biochemical composition of the RBC membrane?
s w sw sw sw s w s w sw sw s w sw
a. 52% protein, 40% lipid, 8% carbohydrate sw sw sw sw sw
b. 40% protein, 8% lipid, 52% carbohydrate sw sw sw sw sw
c. 8% protein, 52% lipid, 40% carbohydratesw sw sw sw sw
d. 8% lipid, 40% carbohydrate, 52% proteinsw sw sw sw sw
sw 11. All of the following biochemical changes are associated with loss of red blood cell viability upon storage
s w sw sw sw sw sw sw sw sw sw sw sw sw sw s w sw sw
except:
a. Decreased pH. c. Increased ATP level. sw sw sw
b. Loss of red blood cell function. d. Decreased glucose consumption.
sw sw sw sw sw s w sw sw
sw 12. Which red blood cell preservative has a storage time of 35 days?
s w sw sw sw sw s w s w sw sw s w s w sw
a. ACD c. AS-1
b. CPDA-1 d. CPD
sw 13. The RBC membrane is relatively permeable to all of the following except:
s w sw sw sw sw sw sw sw sw sw sw sw
a. Chloride. c. Bicarbonate.
b. Sodium. d. Water. s w
14. What percentage of platelets is sequestered in the spleen as functional reserve after being released fromK th
sw sw sw sw sw sw sw sw sw sw sw sw sw sw sw sw sw s w
e bone marrow? sw sw
a. 30% c. 10%
b. 50% d. 25%
sw 15. What is the major biochemical consideration in plateletKstorage?
s w sw sw sw s w s w sw sw
a. Glucose metabolism c. Production of carbon dioxide
sw sw sw sw
b. Oxygen supply d.K Regulation ofKpH sw s w s w
16. What would the hemoglobin-
sw sw sw sw sw
oxygen dissociation curve depict in aKpatient exhibitingKclinical signs of alkalosis?
sw sw sw sw sw sw sw sw sw
a. Normal c. Shift toKthe right sw sw
b. Shift to the left d.K None of the above
sw sw sw s w sw sw s w
sw 17. Name the main lipid components of a red blood cell membrane.
s w sw s w sw sw s w s w sw sw sw s w
a. Phospholipid c. Glycolipid
b. Sphingomyelin d. Glycophorin A s w sw
sw 18. The ABO bloodKgroups were discovered in 1901 by whom?
s w sw sw s w s w sw s w sw sw
a. CharlesKDrew c. Loutit and Mollison sw sw
b. KarlKLandsteiner d. Edward Lindeman s w sw
sw 19. A standing order of plateletsKwas shipped to your facility by your supplier. It was inadvertently left in t
s w sw sw s w s w s w sw sw sw sw s w s w sw s w s w sw sw sw
h e corner of the departmentKuntil discovered 36 hours later. What would the appropriate action be for the bl
sw sw sw sw sw sw sw sw sw sw sw sw sw sw sw sw sw sw
ood banker? sw
a. If the temperature in the box was 22 +/-
sw sw sw sw sw sw sw sw
2°C and the platelet swirl seemed OK, it would be OK to accept the unit into inventor y.
sw sw sw sw sw sw sw sw sw sw s w sw sw sw sw sw sw
b. The platelets have fallen outside the supplier’s quality assurance. The unit should be disc
sw sw sw sw sw sw sw sw sw sw sw sw sw
arded because the pH has probably dropped too low and platelet activation has be en co
sw sw sw sw sw sw sw sw sw sw sw sw sw sw sw
mpromised.
c. If the temperature was 1°C to 6°C and the platelet swirl seemed OK, it would be OK to
sw sw sw sw sw sw sw sw sw sw sw sw sw sw sw sw sw
This study source was downloaded by 100000826342158 from CourseHero.com on 09-15-
sw s w s w s w s w s w s w s w s w s w
2021 17:54:15 GMT -
s w s w s w
https://www.coursehero.com/file/25537437/ch01rtf/
,https://www.stuvia.com/
accept the unit into inventory. sw sw sw sw
d. If the platelets appeared OK and passed the platelet swirl test after being placed on the
sw sw sw sw sw sw sw sw sw sw sw sw sw sw sw s
agitator, they could be accepted into the inventory.
w sw sw sw sw sw sw sw
20. Which metabolic pathway permits the accumulation of 2,3 diphosphoglycerate (2,3-DPG)?
sw s w sw sw sw sw sw sw sw sw sw
a. Glycolysis c. Pentose phosphate shunt sw sw
b. Luebering-Rapoport shunt d. Methemoglobin reductase sw s w sw
21. All of the following are consistent with a "shift to the right" of the hemoglobin-oxygen dissociation curve
sw s w sw sw sw sw sw sw sw sw sw sw sw sw sw sw sw sw
except:
a. Increased 2,3-DPG. sw
b. 50% O2 saturation to tissues. sw s w sw sw
c. Decreased 2,3-DPG. sw
d. Decreased hemoglobin affinity for O2. sw sw sw sw
sw 22. What is the normal platelet count range per cubic millimeter?
s w sw sw s w s w s w sw s w sw sw
a. 100 to 350 c. 50,000 to 200,000
sw s w sw sw
b. 150,000 to 350,000 d. 350,000 to 500,000 sw sw s w sw s w
sw 23. What cryoprotective agent is added to red blood cells upon freezing?
s w sw sw s w sw sw sw sw sw s w sw
a. Dextrose c. Glycerol
b. Adsol d. All of the above s w sw sw sw
24. If platelets are to be stored for 5 days on a rotator, what isKtheKoptimal storageKtemperature?
sw s w sw sw sw sw sw sw s w sw sw sw sw sw sw sw
a. 1°C to 6°C c. 35°CKto 37°C
sw sw sw
b. 20°C to 24°C d. 1°C toK10°C
sw sw s w sw
sw 25. What role do platelets play in hemostasis?
s w sw s w s w s w sw s w
a. Maintenance of vascular integrity sw sw sw
b. Initial arrest of bleeding by platelet plugKformation sw sw sw sw sw sw
c. Stabilization of the hemostatic plug sw sw sw sw
d. All of the above sw sw sw
sw 26. Which of the following best describes "integral"Kmembrane proteins?
s w sw sw sw sw s w sw s w
a. Reside at the cytoplasmicKsurface of membrane sw sw sw sw sw
b. Span the entire membrane surface sw sw sw sw
c. Form the red bloodKcellKcytoskeleton sw sw sw
d. None of the above sw sw sw
sw 27. How is stroma-freeKhemoglobin solution prepared?
s w sw s w sw sw
a. OutdatedKred blood cells are concentrated, and stroma is removed. sw sw sw sw sw sw sw sw
b. Outdated red blood cellsKare diluted with saline, and stroma is removed. sw sw sw sw sw sw sw sw sw sw
c. OutdatedKred blood cellsKare lysed, and stroma is removed. sw sw sw sw sw sw sw
d. None of the above sw sw sw
sw 28. What is the normal lifeKspan of an RBC?
s w sw s w s w s w sw sw s w
a. 100 days sw c. 120 hours sw
b. 120 days sw d. 2 days
s w s w s w
29. Regarding loss of RBC membrane deformability, all of the following are true except:
sw s w sw sw sw sw sw sw sw sw sw sw sw sw
a. Increase in ATP level. sw sw sw
b. Decrease in ATP level. sw sw sw
This study source was downloaded by 100000826342158 from CourseHero.com on 09-15-
sw s w s w s w s w s w s w s w s w s w
2021 17:54:15 GMT -
s w s w s w
https://www.coursehero.com/file/25537437/ch01rtf/
TRANSFUSIONPRACTICES7THEDITIONBY
DENISEMHARMENING
9780803668881CHAPTER1-29COMPLETE
GUIDE
,https://www.stuvia.com/
Chapter 1 RBCs and Platelet Preservation: Historical Perspectives and Current Trends
sw sw sw sw sw sw sw sw sw sw
Multiple Choice sw
Identify the choice that best completes the statement or answers the question.
sw sw sw sw sw sw sw sw sw sw sw
1. Which metabolic pathway is responsible for generating 90% of the ATP for the RBC?
sw sw sw sw sw sw sw sw sw sw sw sw sw
a. Pentose phosphate shunt c. Glycolysis sw sw
b. Luebering-Rapoport shunt d. Methemoglobin reductase sw s w sw
2. A unit of blood was returned to the blood bank before it was spiked. Apparently the patient’s IV failed. The
sw sw sw sw sw sw sw sw sw sw sw sw sw sw sw sw sw sw sw sw
unit of blood was outside the blood bank for 35 minutes. Which of the statements below is most a ccurate?
sw sw sw sw sw sw sw sw sw sw sw sw sw sw sw sw sw s w sw
a. The unit of blood should be discarded immediately. sw sw sw sw sw sw sw
b. The unit of blood can be returned to inventory. sw sw sw sw sw sw sw sw
c. The unit of blood must be transfused within 4 hours or be discarded at the end of that time.
sw sw sw sw s w sw sw sw sw sw sw sw sw sw sw sw sw sw
d. The unit of blood must be transfused with 24 hours. sw sw sw sw sw sw sw sw sw
3. What is the average diameter of a platelet?
sw sw sw sw s w sw sw
a. 5 to 10 µm s w s w sw c. 1 to 2 µm sw s w sw
b. 2 to 4 µm s w s w sw d. 4 to 6 µm sw sw sw
4. In the normal hemoglobin-
sw sw sw
oxygen dissociation curve, what percentage of oxygen is releasedKto the tissuesKwhen PO2 averages 4
sw sw sw sw sw sw sw sw sw sw sw s w sw s
0 mm Hg? w sw sw
a. 75% c. 100%
b. 25% d. 50% s w s w
5. What factors are known to influence platelet metabolism and function?
sw sw sw sw sw sw sw sw sw
a. Storage temperature c. Platelet count sw sw
b. Initial pH d. All of theKabove sw s w sw sw
6. Which of the following red blood cellKmorphologies mayKbeKpresent on the peripheral blood smear as a re sult
sw sw sw sw sw sw sw sw sw sw sw sw sw sw sw sw
of loss of RBC membrane?
sw sw sw sw sw
a. Spherocytes c. Burr cells sw
b. Target cells d. Schistocytes sw s w
7. What does the term autologous transfusionKrefer to?
sw sw sw sw sw sw
a. A parent donating blood for his orKher child
sw sw sw sw sw sw sw
b. An individualKdonating bloodKfor a friend sw sw sw sw
c. An individualKdonating blood forKa relative sw sw sw sw
d. AnKindividual donating bloodKfor his or her own transfusion sw sw sw sw sw sw sw
8. What is theKprimary functionKof hemoglobin?
sw sw sw sw
a. Iron metabolism c. Oxygen transport
sw sw
b. Porphyrin synthesis d. Signal transduction sw s w s w
9. All of the followingKareas of red blood cell biology are crucial for normal erythrocyte survival except:
sw sw sw sw sw sw sw sw sw sw sw sw sw sw s w
a. Cellular metabolism. c. Site of the ABO antigen attachment.
sw sw sw sw sw sw
b. RBC membrane. d. Hemoglobin structure.
sw s w sw
This study source was downloaded by 100000826342158 from CourseHero.com on 09-15-
sw s w s w s w s w s w s w s w s w s w
2021 17:54:15 GMT -
s w s w s w
https://www.coursehero.com/file/25537437/ch01rtf/
,https://www.stuvia.com/
sw 10. What is the correct biochemical composition of the RBC membrane?
s w sw sw sw s w s w sw sw s w sw
a. 52% protein, 40% lipid, 8% carbohydrate sw sw sw sw sw
b. 40% protein, 8% lipid, 52% carbohydrate sw sw sw sw sw
c. 8% protein, 52% lipid, 40% carbohydratesw sw sw sw sw
d. 8% lipid, 40% carbohydrate, 52% proteinsw sw sw sw sw
sw 11. All of the following biochemical changes are associated with loss of red blood cell viability upon storage
s w sw sw sw sw sw sw sw sw sw sw sw sw sw s w sw sw
except:
a. Decreased pH. c. Increased ATP level. sw sw sw
b. Loss of red blood cell function. d. Decreased glucose consumption.
sw sw sw sw sw s w sw sw
sw 12. Which red blood cell preservative has a storage time of 35 days?
s w sw sw sw sw s w s w sw sw s w s w sw
a. ACD c. AS-1
b. CPDA-1 d. CPD
sw 13. The RBC membrane is relatively permeable to all of the following except:
s w sw sw sw sw sw sw sw sw sw sw sw
a. Chloride. c. Bicarbonate.
b. Sodium. d. Water. s w
14. What percentage of platelets is sequestered in the spleen as functional reserve after being released fromK th
sw sw sw sw sw sw sw sw sw sw sw sw sw sw sw sw sw s w
e bone marrow? sw sw
a. 30% c. 10%
b. 50% d. 25%
sw 15. What is the major biochemical consideration in plateletKstorage?
s w sw sw sw s w s w sw sw
a. Glucose metabolism c. Production of carbon dioxide
sw sw sw sw
b. Oxygen supply d.K Regulation ofKpH sw s w s w
16. What would the hemoglobin-
sw sw sw sw sw
oxygen dissociation curve depict in aKpatient exhibitingKclinical signs of alkalosis?
sw sw sw sw sw sw sw sw sw
a. Normal c. Shift toKthe right sw sw
b. Shift to the left d.K None of the above
sw sw sw s w sw sw s w
sw 17. Name the main lipid components of a red blood cell membrane.
s w sw s w sw sw s w s w sw sw sw s w
a. Phospholipid c. Glycolipid
b. Sphingomyelin d. Glycophorin A s w sw
sw 18. The ABO bloodKgroups were discovered in 1901 by whom?
s w sw sw s w s w sw s w sw sw
a. CharlesKDrew c. Loutit and Mollison sw sw
b. KarlKLandsteiner d. Edward Lindeman s w sw
sw 19. A standing order of plateletsKwas shipped to your facility by your supplier. It was inadvertently left in t
s w sw sw s w s w s w sw sw sw sw s w s w sw s w s w sw sw sw
h e corner of the departmentKuntil discovered 36 hours later. What would the appropriate action be for the bl
sw sw sw sw sw sw sw sw sw sw sw sw sw sw sw sw sw sw
ood banker? sw
a. If the temperature in the box was 22 +/-
sw sw sw sw sw sw sw sw
2°C and the platelet swirl seemed OK, it would be OK to accept the unit into inventor y.
sw sw sw sw sw sw sw sw sw sw s w sw sw sw sw sw sw
b. The platelets have fallen outside the supplier’s quality assurance. The unit should be disc
sw sw sw sw sw sw sw sw sw sw sw sw sw
arded because the pH has probably dropped too low and platelet activation has be en co
sw sw sw sw sw sw sw sw sw sw sw sw sw sw sw
mpromised.
c. If the temperature was 1°C to 6°C and the platelet swirl seemed OK, it would be OK to
sw sw sw sw sw sw sw sw sw sw sw sw sw sw sw sw sw
This study source was downloaded by 100000826342158 from CourseHero.com on 09-15-
sw s w s w s w s w s w s w s w s w s w
2021 17:54:15 GMT -
s w s w s w
https://www.coursehero.com/file/25537437/ch01rtf/
,https://www.stuvia.com/
accept the unit into inventory. sw sw sw sw
d. If the platelets appeared OK and passed the platelet swirl test after being placed on the
sw sw sw sw sw sw sw sw sw sw sw sw sw sw sw s
agitator, they could be accepted into the inventory.
w sw sw sw sw sw sw sw
20. Which metabolic pathway permits the accumulation of 2,3 diphosphoglycerate (2,3-DPG)?
sw s w sw sw sw sw sw sw sw sw sw
a. Glycolysis c. Pentose phosphate shunt sw sw
b. Luebering-Rapoport shunt d. Methemoglobin reductase sw s w sw
21. All of the following are consistent with a "shift to the right" of the hemoglobin-oxygen dissociation curve
sw s w sw sw sw sw sw sw sw sw sw sw sw sw sw sw sw sw
except:
a. Increased 2,3-DPG. sw
b. 50% O2 saturation to tissues. sw s w sw sw
c. Decreased 2,3-DPG. sw
d. Decreased hemoglobin affinity for O2. sw sw sw sw
sw 22. What is the normal platelet count range per cubic millimeter?
s w sw sw s w s w s w sw s w sw sw
a. 100 to 350 c. 50,000 to 200,000
sw s w sw sw
b. 150,000 to 350,000 d. 350,000 to 500,000 sw sw s w sw s w
sw 23. What cryoprotective agent is added to red blood cells upon freezing?
s w sw sw s w sw sw sw sw sw s w sw
a. Dextrose c. Glycerol
b. Adsol d. All of the above s w sw sw sw
24. If platelets are to be stored for 5 days on a rotator, what isKtheKoptimal storageKtemperature?
sw s w sw sw sw sw sw sw s w sw sw sw sw sw sw sw
a. 1°C to 6°C c. 35°CKto 37°C
sw sw sw
b. 20°C to 24°C d. 1°C toK10°C
sw sw s w sw
sw 25. What role do platelets play in hemostasis?
s w sw s w s w s w sw s w
a. Maintenance of vascular integrity sw sw sw
b. Initial arrest of bleeding by platelet plugKformation sw sw sw sw sw sw
c. Stabilization of the hemostatic plug sw sw sw sw
d. All of the above sw sw sw
sw 26. Which of the following best describes "integral"Kmembrane proteins?
s w sw sw sw sw s w sw s w
a. Reside at the cytoplasmicKsurface of membrane sw sw sw sw sw
b. Span the entire membrane surface sw sw sw sw
c. Form the red bloodKcellKcytoskeleton sw sw sw
d. None of the above sw sw sw
sw 27. How is stroma-freeKhemoglobin solution prepared?
s w sw s w sw sw
a. OutdatedKred blood cells are concentrated, and stroma is removed. sw sw sw sw sw sw sw sw
b. Outdated red blood cellsKare diluted with saline, and stroma is removed. sw sw sw sw sw sw sw sw sw sw
c. OutdatedKred blood cellsKare lysed, and stroma is removed. sw sw sw sw sw sw sw
d. None of the above sw sw sw
sw 28. What is the normal lifeKspan of an RBC?
s w sw s w s w s w sw sw s w
a. 100 days sw c. 120 hours sw
b. 120 days sw d. 2 days
s w s w s w
29. Regarding loss of RBC membrane deformability, all of the following are true except:
sw s w sw sw sw sw sw sw sw sw sw sw sw sw
a. Increase in ATP level. sw sw sw
b. Decrease in ATP level. sw sw sw
This study source was downloaded by 100000826342158 from CourseHero.com on 09-15-
sw s w s w s w s w s w s w s w s w s w
2021 17:54:15 GMT -
s w s w s w
https://www.coursehero.com/file/25537437/ch01rtf/
