CCMLS - Comp Exam questions with answers
If an antibody gives a stronger reaction with RBCs double-
dosed for the target antigen, it shows the dosage effect (or
just "dosage"). The dosage effect is most prominently
identified in antibodies associated with the Duffy, Kidd, Rh,
and MNS blood group systems. Of the options above the
Kidd antibodies - Jka - would be the antibody most likely to
show dosage that is IgG and warm reacting. anti-N is
rarely encountered as a clinically significant antibody. anti-
M is usually IgM and saline reacting. anti-S can show
dosage and is usually stimulated by transfusion exposure
and is IgG but was not an option for this question.
, A patient with infectious mononucleosis presents in the
blood bank with an auto-cold agglutinin. With what
antibody is this most likely associated?
a. anti-I
b. anti-M
c. anti-P1
d. anti-i - ANSWERd. anti-i
A patient admitted to the hospital has a history of Anti-Jka.
When the type and screen is performed, the patient types
as O Rh positive with a negative antibody screen. What is
the next best course of action?
a. crossmatch using O positive units negative for Jka
antigen
, b. crossmatch random units, since the antibody is not
demonstrating reactivity
c. repeat the screen with enzyme-treated screening cells
d. request a new sample - ANSWERa. crossmatch using
O positive units negative for Jka antigen
Always check the patient history for previous antibodies
that may not be showing up in current testing. Antigen type
the units for the historical antibody and give antigen
negative type-specific blood. Anti-Jka is a Kidd antibody.
They are notorious for titers falling below the detectable
level until they are re-stimulated. Can cause delayed
transfusion reactions.
, A MLS performs an antibody workup and finds 1+ and w+
reactions for several of the antibody panel cells. The
reactions do not fit any pattern on the panel. Several
selected panels and a patient phenotype do not reveal any
additional information. The serum is diluted and retested,
but the same reactions persist. What type of antibody may
be causing these results?
a. antibody to a high-frequency antigen
b. antibody to a low-frequency antigen
c. antibody to a high titer low avidity (HTLA) antigen
d. anti-HLA - ANSWERc. antibody to a high titer low avidity
(HTLA) antigen
If an antibody gives a stronger reaction with RBCs double-
dosed for the target antigen, it shows the dosage effect (or
just "dosage"). The dosage effect is most prominently
identified in antibodies associated with the Duffy, Kidd, Rh,
and MNS blood group systems. Of the options above the
Kidd antibodies - Jka - would be the antibody most likely to
show dosage that is IgG and warm reacting. anti-N is
rarely encountered as a clinically significant antibody. anti-
M is usually IgM and saline reacting. anti-S can show
dosage and is usually stimulated by transfusion exposure
and is IgG but was not an option for this question.
, A patient with infectious mononucleosis presents in the
blood bank with an auto-cold agglutinin. With what
antibody is this most likely associated?
a. anti-I
b. anti-M
c. anti-P1
d. anti-i - ANSWERd. anti-i
A patient admitted to the hospital has a history of Anti-Jka.
When the type and screen is performed, the patient types
as O Rh positive with a negative antibody screen. What is
the next best course of action?
a. crossmatch using O positive units negative for Jka
antigen
, b. crossmatch random units, since the antibody is not
demonstrating reactivity
c. repeat the screen with enzyme-treated screening cells
d. request a new sample - ANSWERa. crossmatch using
O positive units negative for Jka antigen
Always check the patient history for previous antibodies
that may not be showing up in current testing. Antigen type
the units for the historical antibody and give antigen
negative type-specific blood. Anti-Jka is a Kidd antibody.
They are notorious for titers falling below the detectable
level until they are re-stimulated. Can cause delayed
transfusion reactions.
, A MLS performs an antibody workup and finds 1+ and w+
reactions for several of the antibody panel cells. The
reactions do not fit any pattern on the panel. Several
selected panels and a patient phenotype do not reveal any
additional information. The serum is diluted and retested,
but the same reactions persist. What type of antibody may
be causing these results?
a. antibody to a high-frequency antigen
b. antibody to a low-frequency antigen
c. antibody to a high titer low avidity (HTLA) antigen
d. anti-HLA - ANSWERc. antibody to a high titer low avidity
(HTLA) antigen
