Goodman and Gilman's The
Pharmacological Basis of Therapeutics
14th Edition
• Author(s)Laurence Brunton; Bjorn
Knollmann
(Goodman & Gilman–Only | Exam-Ready |
Nursing-Focused)
Goodman & Gilman’s The Pharmacological Basis of
Therapeutics, 14th Edition
Chapter: Drug Discovery: From Medicinal Plants to Computer-
Aided Drug Design
,Nursing Pharmacology Test Bank
Drug Discovery: From Medicinal Plants to Computer-Aided
Drug Design
(Goodman & Gilman, 14th Edition — Exam-Ready MCQs)
1.
Which historical source has contributed significantly to
modern drug discovery through identification of bioactive
compounds?
A. Synthetic polymer libraries
B. Medicinal plants used in traditional medicine
C. Industrial solvents
D. Environmental pollutants
Correct Answer: B
Rationale: Goodman & Gilman emphasizes that many drugs
originated from medicinal plants, which provided natural
products serving as pharmacologic leads.
G&G 14e — Drug Discovery: From Medicinal Plants to
Computer-Aided Drug Design
2.
A lead compound in drug discovery is best defined as:
,A. The final marketed drug formulation
B. A compound demonstrating initial desired biological activity
C. An inactive metabolite
D. A compound already approved by regulatory agencies
Correct Answer: B
Rationale: A lead compound is a chemical entity showing
promising biological activity that can be optimized during drug
development.
G&G 14e — Drug Discovery chapter
3.
Lead optimization primarily aims to:
A. Increase manufacturing costs
B. Improve pharmacologic properties such as potency and
selectivity
C. Reduce intellectual property rights
D. Eliminate pharmacokinetic testing
Correct Answer: B
Rationale: Optimization modifies chemical structure to
enhance potency, selectivity, pharmacokinetics, and safety.
G&G 14e — Drug Discovery chapter
4.
, Structure-activity relationships (SAR) are used to:
A. Predict hospital costs
B. Relate chemical structure to pharmacologic activity
C. Replace clinical trials
D. Determine drug packaging
Correct Answer: B
Rationale: SAR analysis helps identify which structural
features influence drug activity and guides rational
modification.
G&G 14e — Drug Discovery chapter
5.
High-throughput screening (HTS) is characterized by:
A. Testing one compound at a time
B. Rapid evaluation of many compounds against biological
targets
C. Exclusively animal testing
D. Manual microscopic analysis only
Correct Answer: B
Rationale: HTS allows automated screening of large compound
libraries to identify potential leads.
G&G 14e — Drug Discovery chapter
Pharmacological Basis of Therapeutics
14th Edition
• Author(s)Laurence Brunton; Bjorn
Knollmann
(Goodman & Gilman–Only | Exam-Ready |
Nursing-Focused)
Goodman & Gilman’s The Pharmacological Basis of
Therapeutics, 14th Edition
Chapter: Drug Discovery: From Medicinal Plants to Computer-
Aided Drug Design
,Nursing Pharmacology Test Bank
Drug Discovery: From Medicinal Plants to Computer-Aided
Drug Design
(Goodman & Gilman, 14th Edition — Exam-Ready MCQs)
1.
Which historical source has contributed significantly to
modern drug discovery through identification of bioactive
compounds?
A. Synthetic polymer libraries
B. Medicinal plants used in traditional medicine
C. Industrial solvents
D. Environmental pollutants
Correct Answer: B
Rationale: Goodman & Gilman emphasizes that many drugs
originated from medicinal plants, which provided natural
products serving as pharmacologic leads.
G&G 14e — Drug Discovery: From Medicinal Plants to
Computer-Aided Drug Design
2.
A lead compound in drug discovery is best defined as:
,A. The final marketed drug formulation
B. A compound demonstrating initial desired biological activity
C. An inactive metabolite
D. A compound already approved by regulatory agencies
Correct Answer: B
Rationale: A lead compound is a chemical entity showing
promising biological activity that can be optimized during drug
development.
G&G 14e — Drug Discovery chapter
3.
Lead optimization primarily aims to:
A. Increase manufacturing costs
B. Improve pharmacologic properties such as potency and
selectivity
C. Reduce intellectual property rights
D. Eliminate pharmacokinetic testing
Correct Answer: B
Rationale: Optimization modifies chemical structure to
enhance potency, selectivity, pharmacokinetics, and safety.
G&G 14e — Drug Discovery chapter
4.
, Structure-activity relationships (SAR) are used to:
A. Predict hospital costs
B. Relate chemical structure to pharmacologic activity
C. Replace clinical trials
D. Determine drug packaging
Correct Answer: B
Rationale: SAR analysis helps identify which structural
features influence drug activity and guides rational
modification.
G&G 14e — Drug Discovery chapter
5.
High-throughput screening (HTS) is characterized by:
A. Testing one compound at a time
B. Rapid evaluation of many compounds against biological
targets
C. Exclusively animal testing
D. Manual microscopic analysis only
Correct Answer: B
Rationale: HTS allows automated screening of large compound
libraries to identify potential leads.
G&G 14e — Drug Discovery chapter
