520 Diagnostics V (Rheum Labs) Actual Exam Questions & Correct Answers | New 2025–2026 Revised Update

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520 DIAGNOSTICS V (RHEUM LABS) [NEW
2025 UPDATE] REVISED EXAM QUESTIONS
WITH CORRECT ANSWERS (VERIFIED
ANSWERS) HIGHEST TEST SCORE A+ GRADE



What is the acute phase response?

What conditions can trigger the acute phase response?
Inflammation (cytokines, IL) triggers the liver to synthesize proteins (CRP,
fibrinogen)

- Infection
- Rheumatic disease
- Cancer
- Tissue injury/necrosis
- Trauma




Specificity vs sensitivity?
Specific: Positive -> rule in
Sensitive: Negative -> rule out
What two labs are used to monitor the acute phase response?



HEUM LABS)
520 DIAGNOSTICS
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V (RHEUM
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CRP (C-reactive protein)
ESR (erythrocyte sedimentation rate)
Markers of inflammation
How is ESR measured?
1) Allow anti-coagulated blood to sediment for 1 hour in a glass tube
2) Rate at which erythrocytes fall (sediment) proportional to increased amount of
proteins that are produced during inflammation (more proteins bind to RBCs and
make them fall faster)
ESR levels of _______ are associated with clinically significant conditions, such as
_______
>100mm/hr

Infection, cancer, rheumatic disease
ESR is used to monitor the disease activity of what?
RA, giant cell arteritis, polymyalgia rheumatica
What factors unrelated to inflammation can increased ESR levels? (6)
Old age
Female
Pregnancy
Anemia
CKD
Obesity
What technical factors can increase ESR levels?
Tilting ESR tube
High room temp
What drugs can falsely increase ESR levels? (6)
Dextran
Methyldopa




HEUM LABS)
520 DIAGNOSTICS
[NEW 2025 UPDATE]
V (RHEUM
REVISED
LABS)EXAM
[NEWQUESTIONS
2025 UPDATE]
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REVISED
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QUESTIONS
31 (VERIFIED
WITH CORRECT
ANSWERS)
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OCPs
Procainamide
Theophylline
Vitamin A
What can decrease ESR levels?
Diseases that change RBC shape or number (PCV, SCD, spherocytosis, etc.)
What technical factors can decrease ESR levels? (3)
Clotting of blood or delay in test >2 hours
Low room temperature
Short ESR tube
Is CRP or ESR more sensitive?

Which one is more specific?
CRP
Both are non-specific
Timeline of CRP levels in acute phase response?
CRP rapidly increases and peaks in 48 hours
When acute phase response resolves, CRP declines and has short half life of 18
hours
Do elevated CRP levels have diagnostic specificity?

What conditions can it be used for monitoring?
No
RA, giant cell arteritis, polymyalgia rheumatica
Baseline levels of CRP and ESR increase with what?
Age and BMI




HEUM LABS)
520 DIAGNOSTICS
[NEW 2025 UPDATE]
V (RHEUM
REVISED
LABS)EXAM
[NEWQUESTIONS
2025 UPDATE]
WITH
REVISED
CORRECT
Page
EXAM
3ANSWERS
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QUESTIONS
31 (VERIFIED
WITH CORRECT
ANSWERS)
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CRP can be specifically correlated to what conditions?

What does baseline CRP tell you?
Cardiovascular disease (CAD, acute MI, HTN)
Marker of future cardiovascular events (may be better than LDL)
What CV disorder is CRP not elevated in?
Angina
hs-CRP <2.0 mg/L or 0.2 mg/dL indicates what?
Low cardiac risk
hs-CRP >2.0 mg/L or 0.2 mg/dL indicates what?
High cardiac risk
T/F: CRP may be better than LDL at monitoring CAD
True
When does CRP peak after MI?

What do levels correlate with?

What do persistently elevated levels indicate?
18-72 hours post-MI

Peak CK-MB levels

Ongoing damage to heart tissue
What four drugs can chronically increased CRP?

Decrease? (2)
Fibrates, statins, niacin, alcohol

Estrogen, progesterone



HEUM LABS)
520 DIAGNOSTICS
[NEW 2025 UPDATE]
V (RHEUM
REVISED
LABS)EXAM
[NEWQUESTIONS
2025 UPDATE]
WITH
REVISED
CORRECT
Page
EXAM
4ANSWERS
of
QUESTIONS
31 (VERIFIED
WITH CORRECT
ANSWERS)
ANSWERS
HIGHEST(VERIFIED
TEST SCORE
ANSWERS)
A+ GRADE.pdf
HIGHEST TEST