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What is a monoclonal antibody, and how is it different from
chemo? - ANSWER
--mAbs are agents that are derived from human or mouse
antibodies or a
combination of
the two
-mAbs search out proteins on the cells surface
-mAbs recognize and bind to specific anatigens on the cells
surface
-natural killer cells and/or cytotoxic proteins of the immune
system recognize
and destroy the marked
tumor cells
-mAbs can also directly induce cell death as well
,-One of the biggest differences is that mAbs cause harm only to
those cells that
are marked or
binded
Should I avoid my grandchildren and other family members
when I am getting
treatment? - ANSWER --it is perfectly safe for you to have
contact with your
loved ones while getting
treatment
-Hugging, kissing, and spending time together while eating are
all safe activities
-Safety with bodily fluids is necessary for the first 48 hours
after receiving
chemo
Can I be intimate with my partner during treatment? -
ANSWER --you should
definiely check with your HCP first
to be sure
-traces of chemo may be present in vaginal fluid for up to
48 hours after
treatment
,-use of a barrier is recommended for this reason for at least the
first 48 hours
When a vesicant extravasation occurs or is suspected, take the
following steps:
- ANSWER -1. Immediately STOP administering the vesicant
and IV fluids
2. Disconnect the IV tubing from the IV device. Do not remove
the IV device or
noncoring port
needle
3. Attempt to aspirate residual vesicant from the IV device or
port needling use
a small (1-3 mL)
syringe
4. Remove the peripheral IV device or port needle
5. Initiate appropriate management measures
Managing Non-DNA Binding Vesicant Extravasation -
ANSWER --Vinca
Alkaloids (vincristine,
vinblastine)
-Do not bind to DNA in healthy cells when they extravasate into
tissue. Indirect
, effect on healthy
tissue
-Treat with heat, elevation, and hyaluronidase local
injection (spreads the
vesicant through the tissue for faster metabolism of the
vesicant agent)
-Usually results in less tissue damage
-Improves over a short period of time (days to weeks(
Management of DNA-Binding Vesicant Extravasation -
ANSWER ---
Anthracyclines (doxorubicin, epirubicin,
daunorubicin, idarubicin)
-Binds to DNA in healthy cells when they extravasate into
tissue
-When not immediately treated with dexrazoxane, the vesicant
remains in the
tissue and invades adjacent
healthy tissue
-Likely to result in more tissue damage
-Left untreated, extravasations become larger and deeper,
worsening over time