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The Cell 8e Ch17 Test Bank
Molecular And Cell Biology (University of Vermont)
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Test Bank
to accompany
The Cell: A Molecular Approach, Eighth Edition
Geoffrey M. Cooper
Chapter 17: Cell Signaling
TEST FILE QUESTIONS
Multiple Choice
1. Signaling by the steroid hormone estrogen is an example of _______ signaling.
a. autocrine
b. endocrine
c. paracrine
d. direct cell-to-cell
Answer: b
Textbook Reference: Signaling Molecules and Their Receptors
Bloom’s Category: 2. Understanding
Learning Objective: Describe the principal modes of cell signaling.
2. Signaling by neurotransmitters is an example of _______ signaling.
a. autocrine
b. endocrine
c. paracrine
d. direct cell-to-cell
Answer: c
Textbook Reference: Signaling Molecules and Their Receptors
Bloom’s Category: 2. Understanding
Learning Objective: Describe the principal modes of cell signaling.
3. Stimulation of T lymphocytes, leading to their synthesis of a growth factor resulting in
T lymphocyte proliferation, is an example of _______ signaling.
a. autocrine
b. endocrine
c. paracrine
d. direct cell-to-cell
Answer: a
Textbook Reference: Signaling Molecules and Their Receptors
Bloom’s Category: 2. Understanding
Learning Objective: Describe the principal modes of cell signaling.
4. Signaling by cadherins is an example of _______ signaling.
a. autocrine
b. endocrine
© 2019 Oxford University Press
Downloaded by elizabeth moses ()
, lOMoARcPSD|62982272
c. paracrine
d. direct cell-to-cell
Answer: d
Textbook Reference: Signaling Molecules and Their Receptors
Bloom’s Category: 2. Understanding
Learning Objective: Describe the principal modes of cell signaling
5. Which signal molecule diffuses through the plasma membrane to ultimately bind
nuclear receptors and influence transcription?
a. Estrogen
b. Nitric oxide
c. Cadherins
d. Nerve growth factor
Answer: a
Textbook Reference: Signaling Molecules and Their Receptors
Bloom’s Category: 1. Remembering
Learning Objective: Explain how steroid hormones regulate gene expression.
6. Steroid hormones usually act via receptors that
a. are coupled to G proteins that activate adenylyl cyclase.
b. activate tyrosine kinases.
c. bind to DNA.
d. activate phospholipase C.
Answer: c
Textbook Reference: Signaling Molecules and Their Receptors
Bloom’s Category: 2. Understanding
Learning Objective: Explain how steroid hormones regulate gene expression.
7. Statins, a class of drugs that are often administered to patients with high cholesterol,
inhibit the biosynthesis of cholesterol. Statin drugs would not be expected to affect the
biosynthetic pathway of which of the following signal molecules?
a. Thyroid hormone
b. Vitamin D3
c. Retinoic acid
d. Estrogen
Answer: c
Textbook Reference: Signaling Molecules and Their Receptors
Bloom’s Category: 2. Understanding
Learning Objective: Explain how steroid hormones regulate gene expression.
8. A glucocorticoid binding to its receptor stimulates
a. phosphorylation of a transcription factor protein that activates a gene.
b. formation of a receptor dimer that triggers an intracellular signal pathway.
c. formation of a receptor dimer that binds to and activates a gene.
d. binding of the receptor monomer to a gene.
Answer: c
© 2019 Oxford University Press
Downloaded by elizabeth moses ()
, lOMoARcPSD|62982272
Textbook Reference: Signaling Molecules and Their Receptors
Bloom’s Category: 2. Understanding
Learning Objective: Explain how steroid hormones regulate gene expression.
9. Nitric oxide is a signal molecule that can
a. bind to surface receptors and activate second messengers.
b. bind to surface receptors and open ion channels.
c. diffuse across cell membranes and bind to receptors that regulate transcription.
d. diffuse across cell membranes and directly alter the activity of intracellular enzymes.
Answer: d
Textbook Reference: Signaling Molecules and Their Receptors
Bloom’s Category: 1. Remembering
Learning Objective: Compare the actions of different types of small signaling molecules.
10. Nitric oxide is considered a paracrine signal molecule because it
a. is slow to diffuse.
b. is produced in very small quantities.
c. is unstable, with a short half-life.
d. binds to cell surface receptors that are very plentiful.
Answer: c
Textbook Reference: Signaling Molecules and Their Receptors
Bloom’s Category: 1. Remembering
Learning Objective: Compare the actions of different types of small signaling molecules.
11. The medical usage of nitroglycerine in heart disease is based on its
a. inhibition of adenylate cyclase and blood vessel contraction.
b. conversion to NO and blood vessel dilation.
c. activation of NO-synthase and muscle cell contraction.
d. promotion of cyclooxygenase and prostaglandin synthesis.
Answer: b
Textbook Reference: Signaling Molecules and Their Receptors
Bloom’s Category: 1. Remembering
Learning Objective: Compare the actions of different types of small signaling molecules.
12. Neurotransmitters act by binding to receptors that are
a. ligand-gated ion channels.
b. located in the cytoplasm.
c. tyrosine-kinase receptors.
d. not coupled to G proteins.
Answer: a
Textbook Reference: Signaling Molecules and Their Receptors
Bloom’s Category: 1. Remembering
Learning Objective: Compare the actions of different types of small signaling molecules.
13. Enkephalins and endorphins bind to the same receptors in the brain as
a. nerve growth factor.
© 2019 Oxford University Press
Downloaded by elizabeth moses ()
The Cell 8e Ch17 Test Bank
Molecular And Cell Biology (University of Vermont)
Scan to open on Studocu
Studocu is not sponsored or endorsed by any college or university
Downloaded by elizabeth moses ()
, lOMoARcPSD|62982272
Test Bank
to accompany
The Cell: A Molecular Approach, Eighth Edition
Geoffrey M. Cooper
Chapter 17: Cell Signaling
TEST FILE QUESTIONS
Multiple Choice
1. Signaling by the steroid hormone estrogen is an example of _______ signaling.
a. autocrine
b. endocrine
c. paracrine
d. direct cell-to-cell
Answer: b
Textbook Reference: Signaling Molecules and Their Receptors
Bloom’s Category: 2. Understanding
Learning Objective: Describe the principal modes of cell signaling.
2. Signaling by neurotransmitters is an example of _______ signaling.
a. autocrine
b. endocrine
c. paracrine
d. direct cell-to-cell
Answer: c
Textbook Reference: Signaling Molecules and Their Receptors
Bloom’s Category: 2. Understanding
Learning Objective: Describe the principal modes of cell signaling.
3. Stimulation of T lymphocytes, leading to their synthesis of a growth factor resulting in
T lymphocyte proliferation, is an example of _______ signaling.
a. autocrine
b. endocrine
c. paracrine
d. direct cell-to-cell
Answer: a
Textbook Reference: Signaling Molecules and Their Receptors
Bloom’s Category: 2. Understanding
Learning Objective: Describe the principal modes of cell signaling.
4. Signaling by cadherins is an example of _______ signaling.
a. autocrine
b. endocrine
© 2019 Oxford University Press
Downloaded by elizabeth moses ()
, lOMoARcPSD|62982272
c. paracrine
d. direct cell-to-cell
Answer: d
Textbook Reference: Signaling Molecules and Their Receptors
Bloom’s Category: 2. Understanding
Learning Objective: Describe the principal modes of cell signaling
5. Which signal molecule diffuses through the plasma membrane to ultimately bind
nuclear receptors and influence transcription?
a. Estrogen
b. Nitric oxide
c. Cadherins
d. Nerve growth factor
Answer: a
Textbook Reference: Signaling Molecules and Their Receptors
Bloom’s Category: 1. Remembering
Learning Objective: Explain how steroid hormones regulate gene expression.
6. Steroid hormones usually act via receptors that
a. are coupled to G proteins that activate adenylyl cyclase.
b. activate tyrosine kinases.
c. bind to DNA.
d. activate phospholipase C.
Answer: c
Textbook Reference: Signaling Molecules and Their Receptors
Bloom’s Category: 2. Understanding
Learning Objective: Explain how steroid hormones regulate gene expression.
7. Statins, a class of drugs that are often administered to patients with high cholesterol,
inhibit the biosynthesis of cholesterol. Statin drugs would not be expected to affect the
biosynthetic pathway of which of the following signal molecules?
a. Thyroid hormone
b. Vitamin D3
c. Retinoic acid
d. Estrogen
Answer: c
Textbook Reference: Signaling Molecules and Their Receptors
Bloom’s Category: 2. Understanding
Learning Objective: Explain how steroid hormones regulate gene expression.
8. A glucocorticoid binding to its receptor stimulates
a. phosphorylation of a transcription factor protein that activates a gene.
b. formation of a receptor dimer that triggers an intracellular signal pathway.
c. formation of a receptor dimer that binds to and activates a gene.
d. binding of the receptor monomer to a gene.
Answer: c
© 2019 Oxford University Press
Downloaded by elizabeth moses ()
, lOMoARcPSD|62982272
Textbook Reference: Signaling Molecules and Their Receptors
Bloom’s Category: 2. Understanding
Learning Objective: Explain how steroid hormones regulate gene expression.
9. Nitric oxide is a signal molecule that can
a. bind to surface receptors and activate second messengers.
b. bind to surface receptors and open ion channels.
c. diffuse across cell membranes and bind to receptors that regulate transcription.
d. diffuse across cell membranes and directly alter the activity of intracellular enzymes.
Answer: d
Textbook Reference: Signaling Molecules and Their Receptors
Bloom’s Category: 1. Remembering
Learning Objective: Compare the actions of different types of small signaling molecules.
10. Nitric oxide is considered a paracrine signal molecule because it
a. is slow to diffuse.
b. is produced in very small quantities.
c. is unstable, with a short half-life.
d. binds to cell surface receptors that are very plentiful.
Answer: c
Textbook Reference: Signaling Molecules and Their Receptors
Bloom’s Category: 1. Remembering
Learning Objective: Compare the actions of different types of small signaling molecules.
11. The medical usage of nitroglycerine in heart disease is based on its
a. inhibition of adenylate cyclase and blood vessel contraction.
b. conversion to NO and blood vessel dilation.
c. activation of NO-synthase and muscle cell contraction.
d. promotion of cyclooxygenase and prostaglandin synthesis.
Answer: b
Textbook Reference: Signaling Molecules and Their Receptors
Bloom’s Category: 1. Remembering
Learning Objective: Compare the actions of different types of small signaling molecules.
12. Neurotransmitters act by binding to receptors that are
a. ligand-gated ion channels.
b. located in the cytoplasm.
c. tyrosine-kinase receptors.
d. not coupled to G proteins.
Answer: a
Textbook Reference: Signaling Molecules and Their Receptors
Bloom’s Category: 1. Remembering
Learning Objective: Compare the actions of different types of small signaling molecules.
13. Enkephalins and endorphins bind to the same receptors in the brain as
a. nerve growth factor.
© 2019 Oxford University Press
Downloaded by elizabeth moses ()
