Harrison's Principles of Internal Medicine
(Vol.1 & Vol.2)
22nd Edition
• Author(s)Joseph Loscalzo; Anthony S.
Fauci; Dennis L. Kasper; Stephen Hauser;
Dan Longo; J. Larry Jameson
Test Bank
Covered
PART 1: Foundations of Clinical Medicine
PART 2: Cardinal Symptoms & Clinical Presentations
PART 3: Clinical Pharmacology
PART 4: Oncology & Hematology
PART 5: Infectious Diseases
PART 6: Cardiovascular Disorders
PART 7: Respiratory Disorders
PART 8: Critical Care Medicine
PART 9: Kidney & Urinary Tract Disorders
PART 10: Gastrointestinal & Hepatobiliary Disorders
,PART 11: Immune-Mediated & Rheumatologic Disorders
PART 12: Endocrinology & Metabolism
PART 13: Neurologic & Psychiatric Disorders
PART 14: Toxicology & Environmental Injury
PART 15: Environmental & Occupational Medicine
PART 16: Genetics, Precision & Systems Medicine
PART 17–20: Special & Emerging Topics
Which of the following best describes a core principle in the
contemporary practice of medicine when caring for patients
with multiple chronic conditions?
A. Prioritize disease-specific targets above patient preferences.
B. Use guideline-directed therapy for every isolated condition
regardless of context.
C. Integrate patient goals, prognosis, and treatment burden into
shared decision-making.
D. Avoid deprescribing to prevent symptom recurrence.
Answer: C
Rationale: Modern practice emphasizes individualized care that
balances guideline recommendations with patient goals,
prognosis, and treatment burden—especially in multimorbidity.
Citation: Harrison’s, 22nd ed. — Chapter: The Practice of
Medicine.
A 72-year-old with limited life expectancy is admitted for
heart failure. According to principles in promoting good health,
which nursing intervention is most consistent with goals-of-
,care–focused prevention?
A. Initiate all age-based cancer screening immediately.
B. Emphasize advance-care planning and preventive measures
aligned with life expectancy.
C. Schedule colonoscopy regardless of comorbidities.
D. Stop all vaccines to avoid adverse events.
Answer: B
Rationale: Prevention should be individualized; for patients
with limited life expectancy focus on meaningful preventive
measures (eg, advance-care planning, symptom prevention)
rather than routine age-based screens.
Citation: Harrison’s, 22nd ed. — Chapter: Promoting Good
Health.
A parent refuses a routine childhood vaccine due to safety
concerns. Which is the best first-step nursing approach
informed by vaccine opposition and hesitancy?
A. Dismiss the family and refuse to provide care.
B. Provide empathetic listening, ask about specific concerns,
and correct misunderstandings.
C. Force vaccination without consent.
D. Ignore the refusal and document nothing.
Answer: B
Rationale: Addressing hesitancy begins with respectful
communication, eliciting concerns, and offering clear, evidence-
based information to support decision-making.
Citation: Harrison’s, 22nd ed. — Chapter: Vaccine Opposition
and Hesitancy.
, A hospitalized patient declines a recommended diagnostic
test. According to decision-making in clinical medicine, the
nurse should first:
A. Obtain a court order for the test.
B. Provide information about risks/benefits and assess decision-
making capacity.
C. Tell the patient they will be discharged.
D. Proceed with the test because it is clinically indicated.
Answer: B
Rationale: Ethical decision-making requires ensuring informed
refusal — provide information and assess capacity before taking
coercive steps.
Citation: Harrison’s, 22nd ed. — Chapter: Decision-Making in
Clinical Medicine.
Precision medicine uses genetic information to guide therapy.
Which statement describes a nursing implication of precision
medicine and clinical care?
A. Genetic results never affect medication selection.
B. Nurses must recognize how genomic data can change drug
dosing and educate patients about implications.
C. Precision medicine removes the need for patient history.
D. Genetic tests are always diagnostic of disease.
Answer: B
Rationale: Nurses need to understand that genomic data can
alter pharmacotherapy (dosing, alternatives), counseling, and
surveillance, and to teach patients about
implications/limitations.
(Vol.1 & Vol.2)
22nd Edition
• Author(s)Joseph Loscalzo; Anthony S.
Fauci; Dennis L. Kasper; Stephen Hauser;
Dan Longo; J. Larry Jameson
Test Bank
Covered
PART 1: Foundations of Clinical Medicine
PART 2: Cardinal Symptoms & Clinical Presentations
PART 3: Clinical Pharmacology
PART 4: Oncology & Hematology
PART 5: Infectious Diseases
PART 6: Cardiovascular Disorders
PART 7: Respiratory Disorders
PART 8: Critical Care Medicine
PART 9: Kidney & Urinary Tract Disorders
PART 10: Gastrointestinal & Hepatobiliary Disorders
,PART 11: Immune-Mediated & Rheumatologic Disorders
PART 12: Endocrinology & Metabolism
PART 13: Neurologic & Psychiatric Disorders
PART 14: Toxicology & Environmental Injury
PART 15: Environmental & Occupational Medicine
PART 16: Genetics, Precision & Systems Medicine
PART 17–20: Special & Emerging Topics
Which of the following best describes a core principle in the
contemporary practice of medicine when caring for patients
with multiple chronic conditions?
A. Prioritize disease-specific targets above patient preferences.
B. Use guideline-directed therapy for every isolated condition
regardless of context.
C. Integrate patient goals, prognosis, and treatment burden into
shared decision-making.
D. Avoid deprescribing to prevent symptom recurrence.
Answer: C
Rationale: Modern practice emphasizes individualized care that
balances guideline recommendations with patient goals,
prognosis, and treatment burden—especially in multimorbidity.
Citation: Harrison’s, 22nd ed. — Chapter: The Practice of
Medicine.
A 72-year-old with limited life expectancy is admitted for
heart failure. According to principles in promoting good health,
which nursing intervention is most consistent with goals-of-
,care–focused prevention?
A. Initiate all age-based cancer screening immediately.
B. Emphasize advance-care planning and preventive measures
aligned with life expectancy.
C. Schedule colonoscopy regardless of comorbidities.
D. Stop all vaccines to avoid adverse events.
Answer: B
Rationale: Prevention should be individualized; for patients
with limited life expectancy focus on meaningful preventive
measures (eg, advance-care planning, symptom prevention)
rather than routine age-based screens.
Citation: Harrison’s, 22nd ed. — Chapter: Promoting Good
Health.
A parent refuses a routine childhood vaccine due to safety
concerns. Which is the best first-step nursing approach
informed by vaccine opposition and hesitancy?
A. Dismiss the family and refuse to provide care.
B. Provide empathetic listening, ask about specific concerns,
and correct misunderstandings.
C. Force vaccination without consent.
D. Ignore the refusal and document nothing.
Answer: B
Rationale: Addressing hesitancy begins with respectful
communication, eliciting concerns, and offering clear, evidence-
based information to support decision-making.
Citation: Harrison’s, 22nd ed. — Chapter: Vaccine Opposition
and Hesitancy.
, A hospitalized patient declines a recommended diagnostic
test. According to decision-making in clinical medicine, the
nurse should first:
A. Obtain a court order for the test.
B. Provide information about risks/benefits and assess decision-
making capacity.
C. Tell the patient they will be discharged.
D. Proceed with the test because it is clinically indicated.
Answer: B
Rationale: Ethical decision-making requires ensuring informed
refusal — provide information and assess capacity before taking
coercive steps.
Citation: Harrison’s, 22nd ed. — Chapter: Decision-Making in
Clinical Medicine.
Precision medicine uses genetic information to guide therapy.
Which statement describes a nursing implication of precision
medicine and clinical care?
A. Genetic results never affect medication selection.
B. Nurses must recognize how genomic data can change drug
dosing and educate patients about implications.
C. Precision medicine removes the need for patient history.
D. Genetic tests are always diagnostic of disease.
Answer: B
Rationale: Nurses need to understand that genomic data can
alter pharmacotherapy (dosing, alternatives), counseling, and
surveillance, and to teach patients about
implications/limitations.
