Harrison’s-Based Medical-Surgical Nursing MCQ Study Guide & Practice Test Bank

Harrison's Principles of Internal Medicine
(Vol.1 & Vol.2)
22nd Edition
• Author(s)Joseph Loscalzo; Anthony S.
Fauci; Dennis L. Kasper; Stephen Hauser;
Dan Longo; J. Larry Jameson
Test Bank




Covered

PART 1: Foundations of Clinical Medicine

PART 2: Cardinal Symptoms & Clinical Presentations

PART 3: Clinical Pharmacology

PART 4: Oncology & Hematology

PART 5: Infectious Diseases

PART 6: Cardiovascular Disorders

PART 7: Respiratory Disorders

PART 8: Critical Care Medicine

PART 9: Kidney & Urinary Tract Disorders

PART 10: Gastrointestinal & Hepatobiliary Disorders

,PART 11: Immune-Mediated & Rheumatologic Disorders

PART 12: Endocrinology & Metabolism

PART 13: Neurologic & Psychiatric Disorders

PART 14: Toxicology & Environmental Injury

PART 15: Environmental & Occupational Medicine

PART 16: Genetics, Precision & Systems Medicine

PART 17–20: Special & Emerging Topics




1. Chapter: The Practice of Medicine
Q1. A 68-year-old patient arrives with acute shortness of
breath and confusion. According to core principles of
clinical practice, which immediate nursing action best
aligns with initial priorities of care?
A. Obtain a detailed family history.
B. Measure orthostatic vital signs.
C. Ensure airway patency and assess oxygenation.
D. Begin discharge teaching.
Answer: C
Rationale: Initial practice-of-medicine priorities emphasize
immediate assessment and stabilization (airway, breathing,
circulation); oxygenation assessment and ensuring airway
patency are the first nursing steps in acute distress.
Citation: Harrison’s Principles of Internal Medicine, 22nd
ed., The Practice of Medicine.

,2. Chapter: Promoting Good Health
Q2. For community health promotion, which nursing
intervention most effectively addresses primary
prevention?
A. Screening for colorectal cancer.
B. Administering HPV vaccination to adolescents.
C. Ordering a lipid panel for an adult.
D. Teaching inhaler technique to a patient with COPD.
Answer: B
Rationale: Primary prevention prevents disease before it
occurs (vaccination). Screening and secondary/tertiary
interventions follow afterward.
Citation: Harrison’s Principles of Internal Medicine, 22nd
ed., Promoting Good Health.
3. Chapter: Vaccine Opposition and Hesitancy
Q3. A parent expresses vaccine hesitancy. Which nurse
response is most consistent with evidence-based strategies
to increase vaccine acceptance?
A. Provide a long literature review to the parent.
B. Give an empathetic, strong clinician recommendation
and address specific concerns.
C. Warn the parent of legal consequences for refusing
vaccines.
D. Avoid discussing vaccines to prevent conflict.
Answer: B
Rationale: A clear, empathetic, strong recommendation
from a trusted clinician and direct addressing of concerns

, is the most effective approach to reduce hesitancy.
Citation: Harrison’s Principles of Internal Medicine, 22nd
ed., Vaccine Opposition and Hesitancy.
4. Chapter: Decision-Making in Clinical Medicine
Q4. When a patient presents with non-specific symptoms,
which decision-making principle should the nurse apply
first to avoid premature closure?
A. Assume the most common diagnosis without testing.
B. Use a structured differential and gather focused data
before finalizing plan.
C. Defer all decisions to physicians.
D. Order all possible diagnostic tests simultaneously.
Answer: B
Rationale: Structured problem-solving and collecting
targeted data reduces diagnostic error and premature
closure; nurses support this by focused assessment and
escalation.
Citation: Harrison’s Principles of Internal Medicine, 22nd
ed., Decision-Making in Clinical Medicine.
5. Chapter: Precision Medicine and Clinical Care
Q5. A patient’s tumor genomic profiling reveals a
targetable mutation. Which nursing implication is most
important when coordinating precision-guided therapy?
A. Ignore genetic counseling because it’s not a nursing role.
B. Educate patient about implications of targeted therapy,
potential side effects, and need for monitoring.