Medical-Surgical Nursing Study Guide & MCQ Test Bank – Fast Revision

Harrison's Principles of Internal Medicine
(Vol.1 & Vol.2)
22nd Edition
• Author(s)Joseph Loscalzo; Anthony S.
Fauci; Dennis L. Kasper; Stephen Hauser;
Dan Longo; J. Larry Jameson
Test Bank




Covered

PART 1: Foundations of Clinical Medicine

PART 2: Cardinal Symptoms & Clinical Presentations

PART 3: Clinical Pharmacology

PART 4: Oncology & Hematology

PART 5: Infectious Diseases

PART 6: Cardiovascular Disorders

PART 7: Respiratory Disorders

PART 8: Critical Care Medicine

PART 9: Kidney & Urinary Tract Disorders

PART 10: Gastrointestinal & Hepatobiliary Disorders

,PART 11: Immune-Mediated & Rheumatologic Disorders

PART 12: Endocrinology & Metabolism

PART 13: Neurologic & Psychiatric Disorders

PART 14: Toxicology & Environmental Injury

PART 15: Environmental & Occupational Medicine

PART 16: Genetics, Precision & Systems Medicine

PART 17–20: Special & Emerging Topics




1. The primary goal of evidence-based medicine is to:
A. Replace clinical judgment with research data
B. Standardize care regardless of patient context
C. Integrate best evidence with clinical expertise and patient
values
D. Prioritize cost containment over outcomes
Correct Answer: C
Rationale: Evidence-based medicine balances scientific
evidence, clinician expertise, and patient preferences to guide
optimal care decisions.
Citation: Harrison’s Principles of Internal Medicine, 22nd ed.,
Chapter 1: The Practice of Medicine


2. Which determinant has the greatest overall impact on
population health outcomes?

,A. Access to specialty care
B. Genetic predisposition
C. Social and environmental factors
D. Availability of advanced diagnostics
Correct Answer: C
Rationale: Social determinants such as housing, education,
income, and environment account for the largest proportion of
health outcomes.
Citation: Harrison’s Principles of Internal Medicine, 22nd ed.,
Chapter 2: Promoting Good Health


3. Vaccine hesitancy is MOST commonly driven by:
A. Lack of vaccine availability
B. Religious prohibition
C. Concerns about safety and mistrust of institutions
D. Cost of immunization
Correct Answer: C
Rationale: Safety concerns and mistrust in health systems are
leading contributors to vaccine opposition.
Citation: Harrison’s Principles of Internal Medicine, 22nd ed.,
Chapter 3: Vaccine Opposition and Hesitancy


4. Shared decision-making is MOST appropriate when:

, A. Evidence clearly favors one treatment
B. Patient capacity is impaired
C. Multiple reasonable options exist with trade-offs
D. Emergency intervention is required
Correct Answer: C
Rationale: Shared decision-making is essential when choices
involve patient values and comparable outcomes.
Citation: Harrison’s Principles of Internal Medicine, 22nd ed.,
Chapter 4: Decision-Making in Clinical Medicine


5. Precision medicine primarily aims to:
A. Eliminate population-based guidelines
B. Tailor care using genetic, environmental, and lifestyle data
C. Replace clinical assessment with genomics
D. Focus only on rare diseases
Correct Answer: B
Rationale: Precision medicine individualizes prevention and
treatment based on biologic and contextual variability.
Citation: Harrison’s Principles of Internal Medicine, 22nd ed.,
Chapter 5: Precision Medicine and Clinical Care


6. A fundamental principle of screening programs is that:
A. The disease must be rare
B. Screening tests must be diagnostic