1/22/26, 9:02 AM NSG 552 Psychopharmacology Exam 1 - Modules 1-3 Exam comprehensive questions | FREQUENTLY MOST TESTED QUESTIO…
NSG 552 Psychopharmacology Exam 1 - Modules
1-3 Exam comprehensive questions |
FREQUENTLY MOST TESTED QUESTIONS AND
VERIFIED SOLUTIONS @ 2026
Save
Terms in this set (205)
Pharmacokinetics Studies how the body acts on the drug
Pharmacodynamics Studies how the drug acts on the body
First-generation antipsychotic - first developed in the 1950s, first available
treatment for psychosis
- aka typical antipsychotics
- increased risk for EPS, Tardive dyskinesia
- d2 blocker
- Currently 11 FDA-approved and commerically
available FGAs
- Most common differences between individual
FGAs are their potency and side effects
- examples include Thorazine (chlorpromazine),
Haldol (haloperidol), Prolixin (fluphenazine),
perphenazine (Trilafon
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,1/22/26, 9:02 AM NSG 552 Psychopharmacology Exam 1 - Modules 1-3 Exam comprehensive questions | FREQUENTLY MOST TESTED QUESTIO…
Second-generation antipsychotic - examples include Abilify (aripiprazole), Seroquel
(quetiapine), Zyprexa (olanzapine), Risperdal
(risperidone), Clozaril (clozapine)
- lower risk of EPS symptoms compared to 1st gen
- higher risk of metabolic side effects
- serotonin-dopamine receptor antagonists
- AKA atypical antipsychotics
EPS Involuntary movements that occur as a side effect
to certina medications. AKA drug induced
movement disorder. May include tardive dyskinesia,
dystonic reactions, parkinsons-like symptoms,
akathesia, NMD, akinesia
- Can be acute or chronic
- related to suppression of D2 dopamine receptors
in the nigrostriatal pathway
Tardive dyskinesia - characterized by involuntary movments in the
face and body
- often induced by long-term use of anitpsychotic
drugs
- can be associated with use of other medication
types (antidepressants, lithium, antihistamines)
- more common with 1st gen antipsychotics
- movements may include: writhing, mouth
puckering, tongue rolling, lip smacking, pill rolling,
tongue protrusion
Upregulation Refers to the activiation of the nervous system. Is
the process by which a cell increases its response
to a subtance or signal from outside the cell to
carry out a specific response
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, 1/22/26, 9:02 AM NSG 552 Psychopharmacology Exam 1 - Modules 1-3 Exam comprehensive questions | FREQUENTLY MOST TESTED QUESTIO…
downregulation Refers to state of calm/relation within nervous
system. Characterized by a decreased response by
a cell to a molecule or neurotransmitter.
Receptor Profiles FGA - Primarily D2 antagonism. Also antagonize
M2, H1, and a1 receptors
SGA - 5-HT2A & D2 antagonism. Rapid D2
dissociation. 5HT2A agonism. Also antagonizes M2,
H1, 5HT2C, and a1 receptors
Binding When a neurotransmitter binds to a receptor on a
receiving cell, it causes ion channels to open or
close.
Affinity The property of a drug that describes its ability to
bind to a receptor
Constant
Unique for each drug-receptor pair as it is
dependent on each of their structures
CYP450 - membrane-bound hemoproteins that play a
pivotal role in the detoxification of xenobiotics,
cellular metabolism, and homeostatis
-Inhibitition or induction of CYP enzymes is a major
mechanism underlying drug-drug interactions
- A CYP450 inhibitor prevents or reduces work by
CYP450 enzymes = decreased drug metabolism
and increased risk for toxicity
- A CYP450 inducer increases rate of hepatic
metabolism = decreased serum concentation of
other drugs metabolized by the same hepatic
isoenzyme
Grapefruit juice is an inhibtior, which can increase
serum levels of certain drugs
https://quizlet.com/1133915729/nsg-552-psychopharmacology-exam-1-modules-1-3-exam-comprehensive-questions-frequently-most-tested-question… 3/27
NSG 552 Psychopharmacology Exam 1 - Modules
1-3 Exam comprehensive questions |
FREQUENTLY MOST TESTED QUESTIONS AND
VERIFIED SOLUTIONS @ 2026
Save
Terms in this set (205)
Pharmacokinetics Studies how the body acts on the drug
Pharmacodynamics Studies how the drug acts on the body
First-generation antipsychotic - first developed in the 1950s, first available
treatment for psychosis
- aka typical antipsychotics
- increased risk for EPS, Tardive dyskinesia
- d2 blocker
- Currently 11 FDA-approved and commerically
available FGAs
- Most common differences between individual
FGAs are their potency and side effects
- examples include Thorazine (chlorpromazine),
Haldol (haloperidol), Prolixin (fluphenazine),
perphenazine (Trilafon
https://quizlet.com/1133915729/nsg-552-psychopharmacology-exam-1-modules-1-3-exam-comprehensive-questions-frequently-most-tested-question… 1/27
,1/22/26, 9:02 AM NSG 552 Psychopharmacology Exam 1 - Modules 1-3 Exam comprehensive questions | FREQUENTLY MOST TESTED QUESTIO…
Second-generation antipsychotic - examples include Abilify (aripiprazole), Seroquel
(quetiapine), Zyprexa (olanzapine), Risperdal
(risperidone), Clozaril (clozapine)
- lower risk of EPS symptoms compared to 1st gen
- higher risk of metabolic side effects
- serotonin-dopamine receptor antagonists
- AKA atypical antipsychotics
EPS Involuntary movements that occur as a side effect
to certina medications. AKA drug induced
movement disorder. May include tardive dyskinesia,
dystonic reactions, parkinsons-like symptoms,
akathesia, NMD, akinesia
- Can be acute or chronic
- related to suppression of D2 dopamine receptors
in the nigrostriatal pathway
Tardive dyskinesia - characterized by involuntary movments in the
face and body
- often induced by long-term use of anitpsychotic
drugs
- can be associated with use of other medication
types (antidepressants, lithium, antihistamines)
- more common with 1st gen antipsychotics
- movements may include: writhing, mouth
puckering, tongue rolling, lip smacking, pill rolling,
tongue protrusion
Upregulation Refers to the activiation of the nervous system. Is
the process by which a cell increases its response
to a subtance or signal from outside the cell to
carry out a specific response
https://quizlet.com/1133915729/nsg-552-psychopharmacology-exam-1-modules-1-3-exam-comprehensive-questions-frequently-most-tested-question… 2/27
, 1/22/26, 9:02 AM NSG 552 Psychopharmacology Exam 1 - Modules 1-3 Exam comprehensive questions | FREQUENTLY MOST TESTED QUESTIO…
downregulation Refers to state of calm/relation within nervous
system. Characterized by a decreased response by
a cell to a molecule or neurotransmitter.
Receptor Profiles FGA - Primarily D2 antagonism. Also antagonize
M2, H1, and a1 receptors
SGA - 5-HT2A & D2 antagonism. Rapid D2
dissociation. 5HT2A agonism. Also antagonizes M2,
H1, 5HT2C, and a1 receptors
Binding When a neurotransmitter binds to a receptor on a
receiving cell, it causes ion channels to open or
close.
Affinity The property of a drug that describes its ability to
bind to a receptor
Constant
Unique for each drug-receptor pair as it is
dependent on each of their structures
CYP450 - membrane-bound hemoproteins that play a
pivotal role in the detoxification of xenobiotics,
cellular metabolism, and homeostatis
-Inhibitition or induction of CYP enzymes is a major
mechanism underlying drug-drug interactions
- A CYP450 inhibitor prevents or reduces work by
CYP450 enzymes = decreased drug metabolism
and increased risk for toxicity
- A CYP450 inducer increases rate of hepatic
metabolism = decreased serum concentation of
other drugs metabolized by the same hepatic
isoenzyme
Grapefruit juice is an inhibtior, which can increase
serum levels of certain drugs
https://quizlet.com/1133915729/nsg-552-psychopharmacology-exam-1-modules-1-3-exam-comprehensive-questions-frequently-most-tested-question… 3/27
