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chamberlain Nr 507 Week 6 case study
Pathophysiology & Clinical Findings of the Disease
1. Based on the review of the history, physical and lab findings what is the most likely
diabetes diagnosis for this patient?
The most likely diabetes diagnosis, based on the patient’s history, physical examination,
and laboratory findings is type 2 diabetes mellitus. The patient’s lab findings meet criteria for
diagnosis of diabetes. According to clinical practice guidelines by the American Diabetes
Association (ADA), patients may display a fasting plasma glucose greater than or equal to 126
mg/dL or an A1C above 6.5% (ADA, 2022).
2. Explain the pathophysiology associated with the chosen diabetes diagnosis.
According to Galicia-Garcia et al. (2020), type 2 diabetes mellitus (T2DM) occurs due to
malfunctioning of the feedback loops between insulin action and insulin secretion which results
in abnormally high level of serum glucose. B-cells, which are responsible for insulin production,
become dysfunctional due to a host of environmental and biological factors. Glucotoxicity and
lipotoxicity that occur in obesity, hyperglycemia, and hyperlipidemia give rise to inflammation,
metabolic and oxidative stress leading to b-cell damage (Galicia-Garcia et al., 2020). As b-cell
function is reduced, so too is the secretion of insulin and the body’s ability to maintain glucose
levels. Insulin resistance, which occurs due to excessive secretion of regulatory hormones that
impair a cell’s insulin receptors or impaired insulin response at target tissue, also contribute to
T2DM (Galicia-Garcia et al., 2020). Insulin resistance impacts glucose production and decreased
glucose uptake in muscle, liver, and adipose tissue. B-cell dysfunction coupled with insulin
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resistance amplifies hyperglycemia leading to the progression of T2DM (Galicia-Garcia et al.,
2020).
3. Identify at least three subjective findings from the case which support the chosen
diagnosis.
Three subjective findings, those reported to the provider by the patient, include
experiencing extreme fatigue, especially the inability to walk during the day, reported insomnia
and needing to urinate greater than 4 times each evening. Additional subjective findings include
feelings of extreme thirst and increase eating habits.
4. Identify at least three objective findings from the case which support the chosen
diagnosis
Objective findings, those observed by the provider during assessment, include increased
BMI and excessive body weight (240 lbs), an observed fruity breath odor, an elevated fasting
glucose greater than 120 mg/dL, an elevated hemoglobin A1C of 7.2%, the presence of glucose
in the urine, and an oral glucose tolerance test of 220 mg/dL.
Management of the Disease
*Utilize the required Clinical Practice Guideline (CPG) to support your treatment
recommendations.
1. Identify two (2) “Evidence A” recommended medication classes for the treatment of this
condition and provide an example (drug name) for each.
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