UNE Biochemistry Final Questions with
Correct Answers | Updated (100% Correct
Answers)
What are the direct products of Beta Oxidation? Answer: NADH
FADH2
Acetyl CoA
What does Acetyl CoA get used for Answer: ketogenesis
allosterically activates Pyruvate Carboxylase
An 11yo girl is brought into the emergency department by her
father. He reports that she has recently been very thirsty and
needing to make frequent trips to the bathroom. At her soccer
game today, she complained of lightheadedness and symptoms did
not resolve even after drinking a power beverage. A rapid dipstick
test revealed glucose in her urine and further diagnostics indicate
with a diagnosis of Type 1 Diabetes. Evaluation of the liver would
indicate an increased amount of which of the following processes?
Answer: Ketogenesis
What is the role of adipose in metabolism? Answer: storage of
triacyglycerols
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,2
appetite regulation, coagulation, immunity, reproduction
A 5yo female is brought into the ED by her mother. She is a type 1
diabetic and has not taken her insulin while away at a day camp.
The child is unresponsive. Which of the following enzymes is
phosphorylated and active under these conditions? Answer:
hormone sensitive lipase
An individual goes to bed around 8 pm and doesn't wake up until 9
am the next morning. During this time, which of the following is the
primary oxidizable substrate in the skeletal muscle? Answer: free
fatty acids
An individual is on a hunger strike and has not eaten in 13 days.
Which of the following best describes their metabolic state?
Answer: The brain will be preferentially oxidizing ketones
In the fasted state, fatty acyl-CoAs are transported across the
mitochondrial membrane. The transport of fatty acids via carnitine
palmitoyl transferase I (CPTI) can be directly inhibited by which of
the following compounds? Answer: Malonyl CoA
Under fasting conditions (ratio of insulin to glucagon <1), elevated
glucagon will activate which of the following enzymes? Answer:
Hormone Sensitive Lipase
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, 3
A well, 2-year-old girl presents to the clinic with symptoms of a viral
illness. Her parents report she has had bouts of vomiting and
diarrhea over the last 24 hours. This morning they could barely
wake her from her crib and she was very weak. Laboratory tests
show low blood glucose (hypoglycemia) and elevated liver enzymes.
There are no ketones present in her urine. The child is hospitalized
and glucose is administered by I.V. Additional laboratory analysis
showed elevated medium-chain fatty acyl carnitines in blood and 6-
8 carbon dicarboxylic acids in the urine. Which of the following
abnormalities is the most likely diagnosis for this child? Answer:
Defect of medium-chain acyl-dehydrogenase
A 22-year-old woman engaging in a political protest goes on a
hunger strike on a prominent corner in a city park. She refuses all
offers of food except for water through the first 2 weeks. Under
these conditions there is a decreased reliance on which of the
following pathways for fuel? Answer: Gluconeogenesis
ATP can be generated by many metabolic pathways in the body.
Which of the following processes generates the most ATP? Answer:
Fatty acid beta oxidation
In liver, which of the following key inhibitory events ensures that
newly synthesized palmitoyl-CoA is not immediately oxidized?
Answer: Inhibition of carnitine-palmitoyl transferase-I (CPT-I) by
malonyl-CoA.
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