HESI 315 Review (2025/2026)
UPDATE|EXAM
QUESTIONS WITH MULTIPLE
CHOICES |VERIFIED & REVISED
ANSWERS (NEW)!!!
OverviewmofmHistamine2mBlockers:
TheremaremcurrentlymfourmH2RAsmavailable:mcimetidine,mranitidine,mfamotidine,mandmnizatidine
Questionm1mofm4
WhichminstructionsmwouldmthemnursemprovidemMr.mEvansmaboutmwhenmtomtakemthemprescribedmra
nitidine?
A.mTakemitmatmbedtimemormwithmmeals.
B.mTakemitmatmbedtime,mormaftermeveningmmeal.
C.mTakemitmaftermwakingmormjustmbeforemmeals.
D.mTakemitmaftermwakingmormwithmmeals.m-
mCORRECTmANSWERSmB.mTakemitmatmbedtime,mormaftermeveningmmeal.
Histamine2mblockersmshouldmbemtakenmatmbedtimemormaftermeveningmmeal.
Questionm2mofm4
Beforemadministeringmcimetidinemtomam27-year-
oldmfemalempatient,mwhichmpatientmparametersmwouldmamnursemensuremhavembeenmassessed?
A.Hepaticmfunction
B.mRenalmfunction
C.mThyroidmfunction
D.mPregnancymstatus
E.mFluidmandmelectrolytemstatusm-mCORRECTmANSWERSmA.Hepaticmfunction
,B.mRenalmfunction
D.mPregnancymstatus
E.mFluidmandmelectrolytemstatus
Questionm3mofm4
Whichmrespiratorymcomplicationmassociatedmwithmcimetidinemismamconcern,masmthemdrugmincrease
smgastricmpH?
A.mPneumonia
B.mAsthmamattack
C.mInterstitialmlungmdisease
D.mExacerbationmofmchronicmobstructivempulmonarymdiseasem(COPD)m-
mCORRECTmANSWERSmA.mPneumonia
Pneumoniamismamconcernminmpatientsmreceivingmcimetidine.mAsmthemdrugmincreasesmgastricmpH,mth
emriskmformpneumoniamalsomincreases.
Questionm4mofm4
Whichmeffectmwouldmamnursemanticipatemmaymoccurmifmampatientmtakingmphenytoinmismgivenmcimeti
dine?
A.mIncreasedmeffectmofmcimetidine
B.mDecreasedmeffectmofmcimetidine
C.mIncreasedmeffectmofmphenytoin
D.mDecreasedmeffectmofmphenytoinm-mCORRECTmANSWERSmC.mIncreasedmeffectmofmphenytoin
Whenmtakenmtogether,mcimetidinemincreasesmthemconcentrationmofmphenytoin,mthusmincreasingmit
smeffect.mThempatientmshouldmbemmonitoredmcloselymtomdeterminemwhethermamdosagemreductionmi
nmphenytoinmismwarranted.
Questionm1mofm8
, Withmwhichmmedicalmconditionmwouldmamnursemexpectmthemhealthmcaremprovidermtomreducemthem
dosagemofmranitidinemduemtompotentialmaccumulationmofmthemdrug?
Kidneymdisease
Crohnmdisease
Hepaticmimpairment
Cardiovascularmdiseasem-mCORRECTmANSWERSmKidneymdisease
Accumulationmofmranitidinemmaymoccurmwithmrenalmimpairment,mandmamdosagemreductionmismneed
edminmthesempatients.
Questionm2mofm8
Whichmoutcomemismanticipatedmasmamresultmofmhistamine2mreceptormblockersmobstructingmhistami
ne2mreceptorsminmthemparietalmcellsminmthemstomach?
Increaseminmhydrogenmionsmandmgastricmacid
Decreaseminmhydrogenmionsmandmgastricmacid
Increaseminmhydrogenmionsmandmdecreaseminmgastricmacid
Decreaseminmhydrogenmionsmandmincreaseminmgastricmacidm-
mCORRECTmANSWERSmDecreaseminmhydrogenmionsmandmgastricmacid
Themconcentrationmofmbothmhydrogenmionsmandmgastricmacidmismdecreasedmwhenmthemhistamine2m
receptorsmaremobstructedmbymhistamine2mreceptormblockers.
Questionm3mofm8
Whichmcomparisonmbetweenmcimetidinemandmranitidinemismaccurate?
Ranitidinemismmorempotentmthanmcimetidine.
Foodmslowsmthemabsorptionmofmranitidinembutmnotmcimetidine.
Ranitidine,mbutmnotmcimetidine,mismwellmabsorbedmfollowingmoralmadministration.
Foodmreducesmthemoverallmeffectsmofmranitidine.m-
mCORRECTmANSWERSmRanitidinemismmorempotentmthanmcimetidine.
Ranitidinemism5mtom12mtimesmmorempotentmthanmcimetidinembutmismlessmpotentmthanmfamotidine.
UPDATE|EXAM
QUESTIONS WITH MULTIPLE
CHOICES |VERIFIED & REVISED
ANSWERS (NEW)!!!
OverviewmofmHistamine2mBlockers:
TheremaremcurrentlymfourmH2RAsmavailable:mcimetidine,mranitidine,mfamotidine,mandmnizatidine
Questionm1mofm4
WhichminstructionsmwouldmthemnursemprovidemMr.mEvansmaboutmwhenmtomtakemthemprescribedmra
nitidine?
A.mTakemitmatmbedtimemormwithmmeals.
B.mTakemitmatmbedtime,mormaftermeveningmmeal.
C.mTakemitmaftermwakingmormjustmbeforemmeals.
D.mTakemitmaftermwakingmormwithmmeals.m-
mCORRECTmANSWERSmB.mTakemitmatmbedtime,mormaftermeveningmmeal.
Histamine2mblockersmshouldmbemtakenmatmbedtimemormaftermeveningmmeal.
Questionm2mofm4
Beforemadministeringmcimetidinemtomam27-year-
oldmfemalempatient,mwhichmpatientmparametersmwouldmamnursemensuremhavembeenmassessed?
A.Hepaticmfunction
B.mRenalmfunction
C.mThyroidmfunction
D.mPregnancymstatus
E.mFluidmandmelectrolytemstatusm-mCORRECTmANSWERSmA.Hepaticmfunction
,B.mRenalmfunction
D.mPregnancymstatus
E.mFluidmandmelectrolytemstatus
Questionm3mofm4
Whichmrespiratorymcomplicationmassociatedmwithmcimetidinemismamconcern,masmthemdrugmincrease
smgastricmpH?
A.mPneumonia
B.mAsthmamattack
C.mInterstitialmlungmdisease
D.mExacerbationmofmchronicmobstructivempulmonarymdiseasem(COPD)m-
mCORRECTmANSWERSmA.mPneumonia
Pneumoniamismamconcernminmpatientsmreceivingmcimetidine.mAsmthemdrugmincreasesmgastricmpH,mth
emriskmformpneumoniamalsomincreases.
Questionm4mofm4
Whichmeffectmwouldmamnursemanticipatemmaymoccurmifmampatientmtakingmphenytoinmismgivenmcimeti
dine?
A.mIncreasedmeffectmofmcimetidine
B.mDecreasedmeffectmofmcimetidine
C.mIncreasedmeffectmofmphenytoin
D.mDecreasedmeffectmofmphenytoinm-mCORRECTmANSWERSmC.mIncreasedmeffectmofmphenytoin
Whenmtakenmtogether,mcimetidinemincreasesmthemconcentrationmofmphenytoin,mthusmincreasingmit
smeffect.mThempatientmshouldmbemmonitoredmcloselymtomdeterminemwhethermamdosagemreductionmi
nmphenytoinmismwarranted.
Questionm1mofm8
, Withmwhichmmedicalmconditionmwouldmamnursemexpectmthemhealthmcaremprovidermtomreducemthem
dosagemofmranitidinemduemtompotentialmaccumulationmofmthemdrug?
Kidneymdisease
Crohnmdisease
Hepaticmimpairment
Cardiovascularmdiseasem-mCORRECTmANSWERSmKidneymdisease
Accumulationmofmranitidinemmaymoccurmwithmrenalmimpairment,mandmamdosagemreductionmismneed
edminmthesempatients.
Questionm2mofm8
Whichmoutcomemismanticipatedmasmamresultmofmhistamine2mreceptormblockersmobstructingmhistami
ne2mreceptorsminmthemparietalmcellsminmthemstomach?
Increaseminmhydrogenmionsmandmgastricmacid
Decreaseminmhydrogenmionsmandmgastricmacid
Increaseminmhydrogenmionsmandmdecreaseminmgastricmacid
Decreaseminmhydrogenmionsmandmincreaseminmgastricmacidm-
mCORRECTmANSWERSmDecreaseminmhydrogenmionsmandmgastricmacid
Themconcentrationmofmbothmhydrogenmionsmandmgastricmacidmismdecreasedmwhenmthemhistamine2m
receptorsmaremobstructedmbymhistamine2mreceptormblockers.
Questionm3mofm8
Whichmcomparisonmbetweenmcimetidinemandmranitidinemismaccurate?
Ranitidinemismmorempotentmthanmcimetidine.
Foodmslowsmthemabsorptionmofmranitidinembutmnotmcimetidine.
Ranitidine,mbutmnotmcimetidine,mismwellmabsorbedmfollowingmoralmadministration.
Foodmreducesmthemoverallmeffectsmofmranitidine.m-
mCORRECTmANSWERSmRanitidinemismmorempotentmthanmcimetidine.
Ranitidinemism5mtom12mtimesmmorempotentmthanmcimetidinembutmismlessmpotentmthanmfamotidine.
