N360 Exam 1 Questions and Answers| New Update with 100% Correct Answers
Alarm Reaction Stage fight or flight
Stage of Resistance physiological response to attempt to adapt to stressors
stage of exhaustion
Selective Serotonin Reuptake Inhibitors a. MOA = SSRIs block the resorption of serotonin
and increases amount in the synapse
b. Common Side Effects
i. h/a, dizziness, sedation, tremor, dry mouth, sweating, somnolence, insomnia, anorexia, N/V,
constipation, diarrhea, stomach upset, impotence, ejaculation diff
Serotonin Norepinephrine Reuptake Inhibitors a. MOA = inhibits reuptake of
neurotransmitters
b. Venlafaxine (Effexor) = most common and dose dependent
c. Common Side Effects
i. Drowsiness, dizziness, h/a, insomnia, palpitations, increased BP, N, diarrhea, constipation, dry
mouth, diaphoresis, sexual dysfunction
Tricyclic Antidepressants a. Imipramine (Tofranil) and Amitriptyline (Elavil)
b. MOA = slows the reabsorption rate of serotonin and norepinephrine; also blocks histamine,
cholinergic, and alpha1-adrenergic receptor sites which leads to unwanted side effects (weight
gain, dry mouth, constipation, drowsiness, dizziness)
c. Side effects
i. Sedation, dizziness, memory impairment, blurred vision, postural hypotension, tachycardia,
N/V, diarrhea, constipation, dry mouth, diaphoresis, sexual dysfunction
d. Narrow therapeutic gap
e. Overdose
, i. Alter thermoregulation, intestinal perforation, sinus tachycardia, OH, CHF, seizures, coma,
prolongation of QRS and PR/QT, urinary retention, blurred vision, constipation, dry mouth, toxic
megacolon, cardiac arrhythmias
Serotonin Antagonist Reuptake Inhibitors a. Wellbutrin (Bupropion)
b. MOA = does not bind to receptors but reduces reuptake
c. Side effects
i. Tremors, dizziness, h/a, insomnia, lower seizure threshold, tachycardia, nausea, diaphoresis,
dry mouth
Noradrenaline and Specific Serotonergic Agent a. Remeron (Mirtazapine)
b. MOA = presynaptic alpha-2 antagonist that has dual action by increasing noradrenergic and
serotonergic neurotransmission
c. Side effects
i. Sedation, drowsiness, hypotension, constipation, weight gain, increased cholesterol and
triglycerides, sexual dysfunction
Monoamine Oxidase Inhibitors a. Blocks the activity of monoamine oxidase which destroys
serotonin, norepinephrine and dopamine
b. Selegiline (Emsam), Tranylcypromine (Parnate), Phenelzine (Nardil), Isocarboxazid (Marplan)
c. Side effects
i. Sedation, blurred vision, palpitations, urinary retention, constipation, diet restrictions (low
tyramine diet as MAO enzyme also lowers levels that prevents high BP), drug-drug interactions,
dry mouth
Discontinuation Syndrome i. Abrupt stoppage of or marked reduction in the dose of an
antidepressant taken continuously for one month
ii. Occur within two to four days and resolve after one or two weeks
iii. S/S
Alarm Reaction Stage fight or flight
Stage of Resistance physiological response to attempt to adapt to stressors
stage of exhaustion
Selective Serotonin Reuptake Inhibitors a. MOA = SSRIs block the resorption of serotonin
and increases amount in the synapse
b. Common Side Effects
i. h/a, dizziness, sedation, tremor, dry mouth, sweating, somnolence, insomnia, anorexia, N/V,
constipation, diarrhea, stomach upset, impotence, ejaculation diff
Serotonin Norepinephrine Reuptake Inhibitors a. MOA = inhibits reuptake of
neurotransmitters
b. Venlafaxine (Effexor) = most common and dose dependent
c. Common Side Effects
i. Drowsiness, dizziness, h/a, insomnia, palpitations, increased BP, N, diarrhea, constipation, dry
mouth, diaphoresis, sexual dysfunction
Tricyclic Antidepressants a. Imipramine (Tofranil) and Amitriptyline (Elavil)
b. MOA = slows the reabsorption rate of serotonin and norepinephrine; also blocks histamine,
cholinergic, and alpha1-adrenergic receptor sites which leads to unwanted side effects (weight
gain, dry mouth, constipation, drowsiness, dizziness)
c. Side effects
i. Sedation, dizziness, memory impairment, blurred vision, postural hypotension, tachycardia,
N/V, diarrhea, constipation, dry mouth, diaphoresis, sexual dysfunction
d. Narrow therapeutic gap
e. Overdose
, i. Alter thermoregulation, intestinal perforation, sinus tachycardia, OH, CHF, seizures, coma,
prolongation of QRS and PR/QT, urinary retention, blurred vision, constipation, dry mouth, toxic
megacolon, cardiac arrhythmias
Serotonin Antagonist Reuptake Inhibitors a. Wellbutrin (Bupropion)
b. MOA = does not bind to receptors but reduces reuptake
c. Side effects
i. Tremors, dizziness, h/a, insomnia, lower seizure threshold, tachycardia, nausea, diaphoresis,
dry mouth
Noradrenaline and Specific Serotonergic Agent a. Remeron (Mirtazapine)
b. MOA = presynaptic alpha-2 antagonist that has dual action by increasing noradrenergic and
serotonergic neurotransmission
c. Side effects
i. Sedation, drowsiness, hypotension, constipation, weight gain, increased cholesterol and
triglycerides, sexual dysfunction
Monoamine Oxidase Inhibitors a. Blocks the activity of monoamine oxidase which destroys
serotonin, norepinephrine and dopamine
b. Selegiline (Emsam), Tranylcypromine (Parnate), Phenelzine (Nardil), Isocarboxazid (Marplan)
c. Side effects
i. Sedation, blurred vision, palpitations, urinary retention, constipation, diet restrictions (low
tyramine diet as MAO enzyme also lowers levels that prevents high BP), drug-drug interactions,
dry mouth
Discontinuation Syndrome i. Abrupt stoppage of or marked reduction in the dose of an
antidepressant taken continuously for one month
ii. Occur within two to four days and resolve after one or two weeks
iii. S/S
