1
CLINICAL IMMUNOLOGY AND
SEROLOGY EXAM 2026 JUST RELEASED
UPDATED STUDY GUIDE RELEVANT TO
ACTUAL SITTING EXAM
1. Which of the following responses is the type of allograft
rejection associated with vascular and parenchymal injury with
lymphocyte infiltrates ?
b . Acute cellular rejection
Which of the following is an example of a tumor specific
antigen ?
a . BCR / ABL fusion protein
Both AFP and hCG exhibit serum elevations in in
b. ovarian germ cell carcinoma
,2
All of the following are recommended for cancer screening in
the groups indicated except
a . CA 125 / women of reproductive age .
The best use of serum tumor markers is considered to be in
c. monitoring patients undergoing cancer treatment
Which of the following markers could be elevated in
nonmalignant liver disease ?
d. All of the above
A woman with breast cancer is treated with a mono clonal
antibody to HER2 . This is an example of
c . passive immunotherapy
,3
8. Which immunosuppressive agent selectively inhibits IL - 2
receptor - mediated activation of T cells and causes clearance
of activated T cells from the circulation ?
d . Daclizumab
Which one of the following donors would be expected to elicit a
positive mixed lymphocyte response in lymphocytes from a
patient who has the HLA - DRB1 * 01 : 01 01:03 alleles ?
c. DRB1 * 01 : 03 , 01:03
14. Which of the following HLA antigens would be ex pected to
elicit an HLA antibody response in a kidney transplant recipient
with the following HLA type : HLA - A 01,03 ; B 07,14 ; C 01,04N
; DRB1 16,07 ?
c . HLA - C * 04
syngeneic graft
isograft; identical twins
, 4
allograft
transplantation of healthy tissue from one person to another
person; also called homograft
same species
xenograft
transplantation (dermis only) from a foreign donor (usually a
pig) and transferred to a human; also called heterograft
Direct allorecognition
recipient cytotoxic T cells from host bind and respond directly
to foreign (allo) HLA proteins MHC I on graft cells.
CD8
mixed lymphocyte reaction (MLR)
in vitro reaction of alloreactive T cells from one individual
against major histocompatibility complex (MHC) antigens on
blood cells from another individual
CLINICAL IMMUNOLOGY AND
SEROLOGY EXAM 2026 JUST RELEASED
UPDATED STUDY GUIDE RELEVANT TO
ACTUAL SITTING EXAM
1. Which of the following responses is the type of allograft
rejection associated with vascular and parenchymal injury with
lymphocyte infiltrates ?
b . Acute cellular rejection
Which of the following is an example of a tumor specific
antigen ?
a . BCR / ABL fusion protein
Both AFP and hCG exhibit serum elevations in in
b. ovarian germ cell carcinoma
,2
All of the following are recommended for cancer screening in
the groups indicated except
a . CA 125 / women of reproductive age .
The best use of serum tumor markers is considered to be in
c. monitoring patients undergoing cancer treatment
Which of the following markers could be elevated in
nonmalignant liver disease ?
d. All of the above
A woman with breast cancer is treated with a mono clonal
antibody to HER2 . This is an example of
c . passive immunotherapy
,3
8. Which immunosuppressive agent selectively inhibits IL - 2
receptor - mediated activation of T cells and causes clearance
of activated T cells from the circulation ?
d . Daclizumab
Which one of the following donors would be expected to elicit a
positive mixed lymphocyte response in lymphocytes from a
patient who has the HLA - DRB1 * 01 : 01 01:03 alleles ?
c. DRB1 * 01 : 03 , 01:03
14. Which of the following HLA antigens would be ex pected to
elicit an HLA antibody response in a kidney transplant recipient
with the following HLA type : HLA - A 01,03 ; B 07,14 ; C 01,04N
; DRB1 16,07 ?
c . HLA - C * 04
syngeneic graft
isograft; identical twins
, 4
allograft
transplantation of healthy tissue from one person to another
person; also called homograft
same species
xenograft
transplantation (dermis only) from a foreign donor (usually a
pig) and transferred to a human; also called heterograft
Direct allorecognition
recipient cytotoxic T cells from host bind and respond directly
to foreign (allo) HLA proteins MHC I on graft cells.
CD8
mixed lymphocyte reaction (MLR)
in vitro reaction of alloreactive T cells from one individual
against major histocompatibility complex (MHC) antigens on
blood cells from another individual
