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Samenvatting Farmacognosie; een inleiding tot medicinale planten en natuurproducten

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11-01-2026

Written in

2023/2024

Een samenvatting van het vak Farmacognosie, gegeven aan de Universiteit Antwerpen.

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FARMACOGNOSIE
POLYKETIDEN

MACROLIDEN

POLYEEN ANTIBIOTICA
Amphotericine
Nyastatine

Reeks geconjugeerde
dubbele bindingen =
onstabiel! In koelkast
bewaren

Werking:
Antifungaal

Mechanisme:
Complexvorming met sterolen in de celmembraan van eukaryoten
10x sterkere binding met ergosterol (fungi) dan cholesterol (zoogdieren)
-> verandering permeabiliteit celwand -> vorming poriën -> verlies van ionen -> celdood

MACROLIDEN ANTIBIOTICA

Geen groot aantal dubbele bindingen
Werking: Antibacterieel tegen gram positieve bacteriën

Mechanisme: Inhibitie van bacteriële proteïne synthese
door binding aan 50S subunit van bacteriële ribosomen

, AVERMECTINES
Ivermectine
Werking:
Breed spectrum nematocide tegen rondwormen
Zeer actief bij Rivier Blindheid & Lymphatische Filariase

Mechanisme:
Bindt aan de chloride kanalen van de wormen -> Te veel chloride komt
de cel binnen -> Hyperpolarisatie -> Verlamming van de spieren -> Dood

TACROLIMUS
Werking:
immunosuppressiva bv na orgaan transplantaties
Ook bij eczeem gebruikt

Mechanisme:
Inhibitie T cel activatie
Ook Sirolimus & Everolimus

DIELS-ALDER CYCLISATIE PRODUCTEN

STATINES
Ook: simvastatine, pravastatine, atorvastatine
Werking:
Verlaging van totaal en LDL-cholesterol

Mechanisme:
Inhibitie van hydroxymethylglutaryl-coA reductase

DICARBOXYLZUREN

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Institution: Universiteit Antwerpen (UA)
Study: Farmaceutische Wetenschappen
Course: Farmacognosie: medicinale planten en natuurproducten

Document information

Uploaded on: January 11, 2026
Number of pages: 14
Written in: 2023/2024
Type: SUMMARY

Subjects

farmacognosie
farmacie
medicinale planten
farmaceutische wetenschappen

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Samenvatting Farmacognosie; een inleiding tot medicinale planten en natuurproducten

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