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Lecture notes of 10 pages for the course Comparative & Integrative physiology at QMUL

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Animal diversity and phylogeny as a framework for comparative
physiology
Learning objective:
1. Familiarity with the names and characteristics of the major animal phyla and selected representative species.

2. Knowledge of animal phylogenetic relationships (at the phylum level) and how a combination of molecular,
morphological and embryological data have been used to determine relationships.

3. Knowledge of Krogh’s principle as a basis for research in animal physiology (with examples).


What is comparative physiology?

 Comparative physiology seeks to answer 2 central questions about how animals work:
1. What is the mechanism by which a function is accomplished? (how the biological system/animal as a whole
function?)
2. How did that mechanism come to be? (why do animals work the way they do)
 Mechanistic physiology:
- the study of mechanisms
- how modern day animals carry out their functions.
 Evolutionary physiology:
- The study of origin
- Why do modern-day animals possess the mechanisms they do?
- Compare animals and infer how process came to be

What is integrative physiology?

 Seeks to understand animal function at all levels of organisation from the molecular to cellular and from
tissue/organ to whole animal behaviour
 Its primary focus is on the integrating control system of physiology and behaviour
- Nervous system
- Endocrine system Control systems (control activity)
First half of the module will be on integrative physiology and second half on comparative physiology for Elphicks
section.

3 topics for the first half of the module

1. Animal diversity- the experimental ‘’material’’ for comparative physiologists
2. Animal phylogeny-an evolutionary framework for comparative physiology. Understanding animals today and in
the past allows us to understand how processes occur
3. Krogh’s principle
1. Animal diversity
 In peter Holland’s book, he recognises 33 animal phyla
 In zoology and physiology studying a tiny number of animals in detail due to abundance, medical or
economically pivotal.

Some of the major animal phyla and examples

1. Chordata- vertebrate, urochrodates, cephalochordates
2. Echinoderms-starfish
3. Annelids-earthworms, leeches
4. Molluscs- snails, mussels, octopus
5. Arthropods-insects, crustaceans, spiders
6. Nematodes-c.elegans
7. Cniderians-hydra, sea anemones

, Vertebrates belong to the phyla that includes invertebrates (urichordates and cephalochordates)

CHARLIE- CUV

EAT- STAR

APPLE- EL

M- SOM

A-I C SPIDER

N- C.elegans

C- SH

LO1. FAMILIARITY WITH THE NAMES & CHARACTERISTICS OF THE MAJOR ANIMAL PHYLA & SELECTIVE
REPRESENTATIVE SPECIES

Now will look at anatomy of one animal from each phyla.

Urochordates- sea squirt

 Urochordates are 1st closest relative to humans
 Does not do much
 Suck water from one opening and release from the second opening
 Marine animal
 Contains heart, reproductive organs, ganglion
 No brain but has a neural ganglion
 Can remove cerebral ganglion, later regrow, therefore good for studying neurogenerative diseases.
 Ganglion= a structure containing a number of nerve cell bodies typically linked by synapses and often forming a
swelling on the nerve fibre and found outside the CNS and in the peripheral NS.
 Genome sequenced in 2002




Cephalochordates-amphioxus

 2nd closest relative to humans

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Uploaded on
March 8, 2021
Number of pages
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Written in
2020/2021
Type
Class notes
Professor(s)
Kermorgant
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