Lecture Notes

Revision lecture
Cell communicate to maintain or establish cell polarity

 With the cellular environment:
- Growth factor
- Growth factor receptor
- ECM
- Integrins
 With the surrounding cells:
- Cell-cell junction (cadherins)
 These communications all influence the ‘’inside’’ of the cell:
- Signalling pathways
- Cytoskeleton (actin, microtubules, IF)
 And lead to cell responses:
- Maintain apical-basal polarity
- Migration




Growth factor and growth factor receptors

, Receptor tyrosine kinase (RTK)

 Paracrine signalling
 Proto-oncogene




 There are different ways for RTK or GF receptor to become oncogenic.
- One of the ways is autocrine signalling, overexpression, gene amplification, receptor mutation.