BCOP EXAM LATEST ACTUAL EXAM Questions with Correct Answers| Latest Update
Guaranteed Success
If del(5q) is present for MDS, what is the treatment of choice? lenalidomide
What is the serum EPO cutoff to give ESAs for low risk MDS? 500
What drug cause ubiquitination of remaining alleles of CK1 alpha? lenalidomide
Lenalidomide is used for which specific chromosomal deletion in MDS? del(5q)
Should you use lenalidomide for del(5q) if EPO level is > 500? no (response rate drops to
~10%)
What endpoint did lenalodimide show superiority to placebo in the MDS-004 trial? RBC
transfusion independence (56% vs 6%)
Is the response rate to lenalidomide higher or lower for patients with complex karyotype MDS?
lower
Is the response rate to lenalidomide higher or lower for patients with high percentage of bone
marrow blasts? lower
What type of drug is azacitidine? hypomethylating agent
What type of drug is decitabine? hypomethylating agent
What 2 drugs are examples of hypomethylating agents? azacitidine and decitabine
,How is azacitidine administered for lower-risk MDS? SC
How is decitabine administered for lower-risk MDS? IV
How many days per 28 day cycle do you give azacitidine for lower-risk MDS? 7
How many days per 28 day cycle do you give decitabine for lower-risk MDS? 5
The CALGB9211 trial demonstrated improved response rate, QoL, reduced leukemic
transformation and survival vs supportive care for lower-risk MDS with what drug?
azacitidine
What is the dose of azacitidine for lower-risk MDS? 75 mg/m2 SC x 7 days
What is the dose of decitabine for lower-risk MDS? 20 mg/m2 IV x 5 days
How long do you continue hypomethylating agents for lower-risk MDS? indefinitely
Are TPO agonists indicated in lower-risk MDS? no
Are WBC growth factors indicated in lower-risk MDS? no
What 2 immunosuppressant agents are used to treat lower-risk MDS? horse ATG and
cyclosporine
What drug showed survival advantage of higher-risk MDS compared to conventional therapy?
azacitidine
,What type of drug can you use as a bridge to transplant for higher-risk MDS?
hypomethylating agents
What type of transplant is used for higher-risk MDS? allo
What type of drug used in MDS binds and sequesters TGF-beta ligands to inhibit erythropoiesis?
luspatercept
Do you use luspatercept for MDS with a high or low EPO level? high
What is the dose of luspatercept for MDS? 1 mg/kg every 3 weeks
Can you titrate up the dose of luspatercept for MDS? yes
Can you use luspatercept for patients who have failed ESAs for MDS? yes
Does luspatercept alter the progression of MDS to AML? no
What drug led to a significant increase in the number of patients that were transfusion
independent at 8 weeks vs placebo in the Medalist trial? luspatercept
How many blasts in blood or bone marrow are required for diagnosis of AML? 20%
What are the 4 cytogenic abnormalities that automatically qualify you for an AML diagnosis
regardless of blast percentage? t(15;17), inv(16), t(16;16), t(8;21)
What cytogenetic abnormality is also known as the PML-RARA gene fusion? t(15;17)
, What cytogenetic abnormality is characteristic of APML? t(15;17)
Is inv(16) considered favorable, intermediate, or poor risk for AML? favorable
Is t(16;16) considered favorable, intermediate, or poor risk for AML? favorable
Is t(8;21) considered favorable, intermediate, or poor risk for AML? favorable
Are core binding factor abnormalities considered favorable, intermediate, or poor risk for AML?
favorable
What are the 3 core binding factor abnormalities in AML? inv(16), t(16;16), t(8;21)
Is t(9;11) considered favorable, intermediate, or poor risk for AML? intermediate
Are more than 3 chromosomal abnormalities considered favorable, intermediate, or poor risk
for AML? poor
Is monosomal karyotype considered favorable, intermediate, or poor risk for AML? poor
Is del(5q) considered favorable, intermediate, or poor risk for AML? poor
Is del(17)p considered favorable, intermediate, or poor risk for AML? poor
Is inv(3) or GATA2 considered favorable, intermediate, or poor risk for AML? poor
Guaranteed Success
If del(5q) is present for MDS, what is the treatment of choice? lenalidomide
What is the serum EPO cutoff to give ESAs for low risk MDS? 500
What drug cause ubiquitination of remaining alleles of CK1 alpha? lenalidomide
Lenalidomide is used for which specific chromosomal deletion in MDS? del(5q)
Should you use lenalidomide for del(5q) if EPO level is > 500? no (response rate drops to
~10%)
What endpoint did lenalodimide show superiority to placebo in the MDS-004 trial? RBC
transfusion independence (56% vs 6%)
Is the response rate to lenalidomide higher or lower for patients with complex karyotype MDS?
lower
Is the response rate to lenalidomide higher or lower for patients with high percentage of bone
marrow blasts? lower
What type of drug is azacitidine? hypomethylating agent
What type of drug is decitabine? hypomethylating agent
What 2 drugs are examples of hypomethylating agents? azacitidine and decitabine
,How is azacitidine administered for lower-risk MDS? SC
How is decitabine administered for lower-risk MDS? IV
How many days per 28 day cycle do you give azacitidine for lower-risk MDS? 7
How many days per 28 day cycle do you give decitabine for lower-risk MDS? 5
The CALGB9211 trial demonstrated improved response rate, QoL, reduced leukemic
transformation and survival vs supportive care for lower-risk MDS with what drug?
azacitidine
What is the dose of azacitidine for lower-risk MDS? 75 mg/m2 SC x 7 days
What is the dose of decitabine for lower-risk MDS? 20 mg/m2 IV x 5 days
How long do you continue hypomethylating agents for lower-risk MDS? indefinitely
Are TPO agonists indicated in lower-risk MDS? no
Are WBC growth factors indicated in lower-risk MDS? no
What 2 immunosuppressant agents are used to treat lower-risk MDS? horse ATG and
cyclosporine
What drug showed survival advantage of higher-risk MDS compared to conventional therapy?
azacitidine
,What type of drug can you use as a bridge to transplant for higher-risk MDS?
hypomethylating agents
What type of transplant is used for higher-risk MDS? allo
What type of drug used in MDS binds and sequesters TGF-beta ligands to inhibit erythropoiesis?
luspatercept
Do you use luspatercept for MDS with a high or low EPO level? high
What is the dose of luspatercept for MDS? 1 mg/kg every 3 weeks
Can you titrate up the dose of luspatercept for MDS? yes
Can you use luspatercept for patients who have failed ESAs for MDS? yes
Does luspatercept alter the progression of MDS to AML? no
What drug led to a significant increase in the number of patients that were transfusion
independent at 8 weeks vs placebo in the Medalist trial? luspatercept
How many blasts in blood or bone marrow are required for diagnosis of AML? 20%
What are the 4 cytogenic abnormalities that automatically qualify you for an AML diagnosis
regardless of blast percentage? t(15;17), inv(16), t(16;16), t(8;21)
What cytogenetic abnormality is also known as the PML-RARA gene fusion? t(15;17)
, What cytogenetic abnormality is characteristic of APML? t(15;17)
Is inv(16) considered favorable, intermediate, or poor risk for AML? favorable
Is t(16;16) considered favorable, intermediate, or poor risk for AML? favorable
Is t(8;21) considered favorable, intermediate, or poor risk for AML? favorable
Are core binding factor abnormalities considered favorable, intermediate, or poor risk for AML?
favorable
What are the 3 core binding factor abnormalities in AML? inv(16), t(16;16), t(8;21)
Is t(9;11) considered favorable, intermediate, or poor risk for AML? intermediate
Are more than 3 chromosomal abnormalities considered favorable, intermediate, or poor risk
for AML? poor
Is monosomal karyotype considered favorable, intermediate, or poor risk for AML? poor
Is del(5q) considered favorable, intermediate, or poor risk for AML? poor
Is del(17)p considered favorable, intermediate, or poor risk for AML? poor
Is inv(3) or GATA2 considered favorable, intermediate, or poor risk for AML? poor
