NR 566 MIDTERM/NR566 ADVANCED
PHARMACOLOGY FOR CARE OF THE
FAMILY MIDTERM EXAM NEWEST 2026
ACTUAL EXAM COMPLETE 300
QUESTIONS AND CORRECT DETAILED
ANSWERS (VERIFIED ANSWERS)
|ALREADY GRADED A+
1. Which process describes the movement of a drug from the
bloodstream into tissues?
A. Absorption
B. Distribution
C. Metabolism
D. Excretion
Answer: B – Distribution
Rationale: Distribution is the process by which a drug moves from
circulation into body tissues. Absorption refers to entry into the
bloodstream; metabolism is biotransformation; excretion is
elimination.
2. A drug that has a high first-pass effect will likely require:
A. Lower oral doses
B. Higher oral doses
,C. Lower IV doses
D. No dose adjustment
Answer: B – Higher oral doses
Rationale: High first-pass metabolism by the liver reduces
bioavailability, so oral doses must be increased to achieve
therapeutic levels.
3. What phase of pharmacokinetics is primarily responsible for
converting a lipid-soluble drug into a water-soluble form?
A. Absorption
B. Distribution
C. Metabolism
D. Excretion
Answer: C – Metabolism
Rationale: The liver metabolizes many drugs, usually converting
them to more water-soluble metabolites for excretion.
4. A drug’s half-life is most useful for determining:
A. Time to steady state
B. Potency
C. Mechanism of action
D. Route of excretion
Answer: A – Time to steady state
Rationale: Half-life indicates how long it takes for the blood
concentration to reduce by half and is key in determining steady
state timing.
5. What does a low therapeutic index indicate?
A. Wide safety margin
B. Narrow safety margin
,C. No need to monitor levels
D. Non-selective drug
Answer: B – Narrow safety margin
Rationale: Low therapeutic index means small differences between
therapeutic and toxic levels; close monitoring is required.
11. A drug that stimulates muscarinic receptors would cause:
A. Bronchodilation
B. Pupillary dilation
C. Increased salivation
D. Tachycardia
Answer: C – Increased salivation
Rationale: Muscarinic stimulation enhances secretions (salivation),
slows heart rate, and constricts pupils.
12. Beta-1 agonists primarily affect:
A. Heart rate and contractility
B. Lung smooth muscle
C. GI motility
D. Bladder contraction
Answer: A – Heart rate and contractility
Rationale: Beta-1 receptors are mainly cardiac, increasing heart
rate and force of contraction.
13. A nonselective beta-blocker can cause:
A. Bronchoconstriction
B. Glycemic control improvement
C. Increased lipolysis
D. Diuresis
, Answer: A – Bronchoconstriction
Rationale: Blocking beta-2 receptors in lungs may cause
bronchoconstriction, especially in asthma.
21. Which opioid receptor is most associated with analgesia?
A. Delta
B. Mu
C. Kappa
D. Sigma
Answer: B – Mu
Rationale: Mu receptors mediate analgesia, respiratory depression,
euphoria, and physical dependence.
22. The most serious acute side effect of opioids is:
A. Constipation
B. Urinary retention
C. Respiratory depression
D. Sedation
Answer: C – Respiratory depression
Rationale: Life-threatening respiratory suppression is the most
dangerous opioid AE.
23. Naloxone works by:
A. Stimulating opioid receptors
B. Blocking opioid receptors
C. Enhancing opioid metabolism
D. Preventing opioid absorption
PHARMACOLOGY FOR CARE OF THE
FAMILY MIDTERM EXAM NEWEST 2026
ACTUAL EXAM COMPLETE 300
QUESTIONS AND CORRECT DETAILED
ANSWERS (VERIFIED ANSWERS)
|ALREADY GRADED A+
1. Which process describes the movement of a drug from the
bloodstream into tissues?
A. Absorption
B. Distribution
C. Metabolism
D. Excretion
Answer: B – Distribution
Rationale: Distribution is the process by which a drug moves from
circulation into body tissues. Absorption refers to entry into the
bloodstream; metabolism is biotransformation; excretion is
elimination.
2. A drug that has a high first-pass effect will likely require:
A. Lower oral doses
B. Higher oral doses
,C. Lower IV doses
D. No dose adjustment
Answer: B – Higher oral doses
Rationale: High first-pass metabolism by the liver reduces
bioavailability, so oral doses must be increased to achieve
therapeutic levels.
3. What phase of pharmacokinetics is primarily responsible for
converting a lipid-soluble drug into a water-soluble form?
A. Absorption
B. Distribution
C. Metabolism
D. Excretion
Answer: C – Metabolism
Rationale: The liver metabolizes many drugs, usually converting
them to more water-soluble metabolites for excretion.
4. A drug’s half-life is most useful for determining:
A. Time to steady state
B. Potency
C. Mechanism of action
D. Route of excretion
Answer: A – Time to steady state
Rationale: Half-life indicates how long it takes for the blood
concentration to reduce by half and is key in determining steady
state timing.
5. What does a low therapeutic index indicate?
A. Wide safety margin
B. Narrow safety margin
,C. No need to monitor levels
D. Non-selective drug
Answer: B – Narrow safety margin
Rationale: Low therapeutic index means small differences between
therapeutic and toxic levels; close monitoring is required.
11. A drug that stimulates muscarinic receptors would cause:
A. Bronchodilation
B. Pupillary dilation
C. Increased salivation
D. Tachycardia
Answer: C – Increased salivation
Rationale: Muscarinic stimulation enhances secretions (salivation),
slows heart rate, and constricts pupils.
12. Beta-1 agonists primarily affect:
A. Heart rate and contractility
B. Lung smooth muscle
C. GI motility
D. Bladder contraction
Answer: A – Heart rate and contractility
Rationale: Beta-1 receptors are mainly cardiac, increasing heart
rate and force of contraction.
13. A nonselective beta-blocker can cause:
A. Bronchoconstriction
B. Glycemic control improvement
C. Increased lipolysis
D. Diuresis
, Answer: A – Bronchoconstriction
Rationale: Blocking beta-2 receptors in lungs may cause
bronchoconstriction, especially in asthma.
21. Which opioid receptor is most associated with analgesia?
A. Delta
B. Mu
C. Kappa
D. Sigma
Answer: B – Mu
Rationale: Mu receptors mediate analgesia, respiratory depression,
euphoria, and physical dependence.
22. The most serious acute side effect of opioids is:
A. Constipation
B. Urinary retention
C. Respiratory depression
D. Sedation
Answer: C – Respiratory depression
Rationale: Life-threatening respiratory suppression is the most
dangerous opioid AE.
23. Naloxone works by:
A. Stimulating opioid receptors
B. Blocking opioid receptors
C. Enhancing opioid metabolism
D. Preventing opioid absorption
