CHAPTER 10 BLOOD AND CIRCULATORY SYSTEM
DISORDERS.
Built around real course units and objectives!
The circulatory system consists of - Answer: cardiovascular system and lymphatic system
Arteries—arterioles - Answer: carry blood away from the heart, walls thick
Veins—venules - Answer: carry blood toward the heart, walls not as thick
Capillaries - Answer: Microcirculation within tissues, smaller disease can get here first
Systemic circulation - Answer: Exchange of gases, nutrients, and wastes in tissues
Pulmonary circulation - Answer: Gas exchange in lungs
Muscle contraction help to - Answer: Push blood back up and help reduce edema
Histology of Arteries and Veins - Answer: Tunica intima, Tunica media, Tunica adventitia
(externa)
Tunica intima - Answer: endothelium (simple squamous epithelium)
Inner layer
Tunica media - Answer: middle layer, mostly smooth muscle
Tunica adventitia (externa) - Answer: connective tissue with fibrocytes, collagen (type I),
and elastic fibers, Vasodialation and constriction
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1
,Composition of Blood - Answer: Plasma, cellular components
Plasma - Answer: Plasma proteins
Cellular component of blood - Answer: Erythrocytes
Leukocytes
Thrombocytes (platelets)
SEE SLIDE 7 Picture/chart - Answer:
Hematopoiesis - Answer: Creation or manufacturing of blood cells
Normal Red Blood Cells looks like - Answer: Cheerios or donuts, Biconcave flexible discs,
No nucleus in mature state
Normal Red blood cells - Answer: appear as biconcave discs
Erythropoietin - Answer: produced in the kidney stimulates erythrocyte production.
Normal Red Blood Cells - Answer: -Contains hemoglobin
--Globin portion
--Heme group
-Life span—120 days
Hemoglobin does - Answer: binds with oxygen
Breakdown of Hemoglobin - Answer: Heme and Globin
Breakdown of Hemoglobin (Heme) - Answer: - Iorn
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, --Recycled to bone marrow or stored
Breakdown of Hemoglobin (globin) - Answer: Aminio acids recycled
Breakdown of Hemoglobin (conjugated) - Answer: - Transported bound to serum albumin
--Blood
--Liver- conjugated with glucuronic acid
--Bilirubin- conjugated
--Bile
Blood Clotting - Answer: Hemostasis
Three steps of Hemostasis - Answer: -Vasoconstriction or vascular spasm after injury (ICE)
-Platelet clot
-Coagulation mechanism
--Plasmin will eventually break down the blood clot.
Hemostasis and Anticoagulant Drugs, how the clot forms and where each type of med
intervenes
Slide 13 - Answer: SPEND TIME ON ESPECIALLY IN BOOK
Intrinsic Pathway - Answer: Activated by endothelial injury in the blood
Extrinsic Pathway - Answer: Activated by tissue and platelet injury
Is calcium required for Anticoagulant drugs to work? T of F - Answer: True
Oral anticoagulants - Answer: Warfarin (Coumadin)
Block synthesis of prothrombin
APPHIA – Crafted with Care and Precision for Academic Excellence.
3
DISORDERS.
Built around real course units and objectives!
The circulatory system consists of - Answer: cardiovascular system and lymphatic system
Arteries—arterioles - Answer: carry blood away from the heart, walls thick
Veins—venules - Answer: carry blood toward the heart, walls not as thick
Capillaries - Answer: Microcirculation within tissues, smaller disease can get here first
Systemic circulation - Answer: Exchange of gases, nutrients, and wastes in tissues
Pulmonary circulation - Answer: Gas exchange in lungs
Muscle contraction help to - Answer: Push blood back up and help reduce edema
Histology of Arteries and Veins - Answer: Tunica intima, Tunica media, Tunica adventitia
(externa)
Tunica intima - Answer: endothelium (simple squamous epithelium)
Inner layer
Tunica media - Answer: middle layer, mostly smooth muscle
Tunica adventitia (externa) - Answer: connective tissue with fibrocytes, collagen (type I),
and elastic fibers, Vasodialation and constriction
APPHIA – Crafted with Care and Precision for Academic Excellence.
1
,Composition of Blood - Answer: Plasma, cellular components
Plasma - Answer: Plasma proteins
Cellular component of blood - Answer: Erythrocytes
Leukocytes
Thrombocytes (platelets)
SEE SLIDE 7 Picture/chart - Answer:
Hematopoiesis - Answer: Creation or manufacturing of blood cells
Normal Red Blood Cells looks like - Answer: Cheerios or donuts, Biconcave flexible discs,
No nucleus in mature state
Normal Red blood cells - Answer: appear as biconcave discs
Erythropoietin - Answer: produced in the kidney stimulates erythrocyte production.
Normal Red Blood Cells - Answer: -Contains hemoglobin
--Globin portion
--Heme group
-Life span—120 days
Hemoglobin does - Answer: binds with oxygen
Breakdown of Hemoglobin - Answer: Heme and Globin
Breakdown of Hemoglobin (Heme) - Answer: - Iorn
APPHIA – Crafted with Care and Precision for Academic Excellence.
2
, --Recycled to bone marrow or stored
Breakdown of Hemoglobin (globin) - Answer: Aminio acids recycled
Breakdown of Hemoglobin (conjugated) - Answer: - Transported bound to serum albumin
--Blood
--Liver- conjugated with glucuronic acid
--Bilirubin- conjugated
--Bile
Blood Clotting - Answer: Hemostasis
Three steps of Hemostasis - Answer: -Vasoconstriction or vascular spasm after injury (ICE)
-Platelet clot
-Coagulation mechanism
--Plasmin will eventually break down the blood clot.
Hemostasis and Anticoagulant Drugs, how the clot forms and where each type of med
intervenes
Slide 13 - Answer: SPEND TIME ON ESPECIALLY IN BOOK
Intrinsic Pathway - Answer: Activated by endothelial injury in the blood
Extrinsic Pathway - Answer: Activated by tissue and platelet injury
Is calcium required for Anticoagulant drugs to work? T of F - Answer: True
Oral anticoagulants - Answer: Warfarin (Coumadin)
Block synthesis of prothrombin
APPHIA – Crafted with Care and Precision for Academic Excellence.
3
