Treatment of mctd Study guides, Class notes & Summaries

ABIM UWORLD-146 Questions with Complete Solutions Diagnosing Mixed Connective Tissue Disease - CORRECT ANSWER Anti-U1-RNP + at least 3 of the following: - Swollen hands or fingers - Myositis or myalgia - Synovitis - Raynaud's phenomenon Drug-induced lupus antibody - CORRECT ANSWER DNA-histone complex (95%) SLE antibody - CORRECT ANSWER ds DNA(97%), Smith Systemic sclerosis antibody - CORRECT ANSWER RNA polymerase II and II Scl-70/anti-topoisomerase I Sjogren's syndrome - CORRECT...

Lesch-Nyhan Syndrome: what causes it and what are manifestations? - ***HGPRT deficiency in purine salvage pathway (this enzyme normally converts hypoxanthine to IMP and guanine to GMP). This deficiency leads to excessive Uric acid production and de novo purine synthesis. It is X linked recessive. Symptoms: hyperuricemia, gout, aggression / self mutilation, mental retardation, dystonia. 2. Treatment for Lesch-Nyhan? - ***Allopurinol / febuxostat second line. Both of these drugs inhibit...

  In the anti-double-stranded DNA procedure, the antigen most commonly utilized is: - Answer: The Crithidia luciliae antigen is used. C. luciliae has giant mitochondrion that contain native DNA that is free from contaminating histone antigens. It is used in SLE diagnosis. C3b function - Answer: which lands on the target surface and becomes part of C5 convertase, is also a powerful opsonin Rheumatoid factor - Answer: anti-Ig*M* or G that binds to the Fc portion of an abnormal IgG. + i...

CBSE Biochem Lesch-Nyhan Syndrome: what causes it and what are manifestations? - correct answersHGPRT deficiency in purine salvage pathway (this enzyme normally converts hypoxanthine to IMP and guanine to GMP). This deficiency leads to excessive Uric acid production and de novo purine synthesis. It is X linked recessive. Symptoms: hyperuricemia, gout, aggression / self mutilation, mental retardation, dystonia. Treatment for Lesch-Nyhan? - correct answersAllopurinol / febuxostat second ...