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Pearl - Amide- vs. Ester-Type Anesthetics - Answer Amide-type anesthetics can be recognized by the "i" in their name before the"-caine" ending (e.g., lidocaine, bupivacaine, mepivacaine, ropivacaine). Ester-type anesthetics do not contain an "i" before the "-caine" ending (e.g., procaine, benzocaine, cocaine, tetracaine). Hypersensitivity to one type of drug in an anesthetic class, such as the ester-type procaine, does not confer cross-reactivity to drugs within the opposite anesth...

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