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Pharmaceutical Chemistry

Heriot-Watt University, Edinburgh (HW)

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HIV-1 and protease inhibitors, Gleevec tyrosine kinase inhibitor, estradiol and raloxifene metabolites estrogen drugs

  • HIV-1 and protease inhibitors, Gleevec tyrosine kinase inhibitor, estradiol and raloxifene metabolites estrogen drugs

  • Summary • 5 pages • 2020
  • Question 1. Refer to this review – Konvalinka et al., Virology 2015 (Fig. 5, pages 408-409). Explain the strategies used by HIV-1 to evade clinically used protease inhibitors. Explain how and why these strategies are effective when interactions between the synthetic drugs and protease are always much stronger than that of interactions between protease and its natural substrate. (max. 500 words) Question 2. See this web-article to gain more information about Gleevec - Question 3. Consider fo...
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