Histotechnology - Tissue Fixation fully solved updated to pass

Histotechnology - Tissue FixationAdditive fixatives Mercuric chloride Chromic acid Picric acid Formaldehyde Glutaraldehyde Osmium tetroxide Potassium dichromate Glyoxal Zinc salts Nonadditive fixatives Alcohols Acetone Acetic Acid Coagulant Fixatives Mercuric acid Chromic acid Picric acid Zinc salts Alcohols Acetone Acetic acid Noncoagulant Fixatives Formaldehyde Glutaraldehyde Osmium Tetroxide Potassium Dichromate Glyoxal Are coagulant fixatives additive, non additive, or both? both Are noncoagulant fixatives additive, non additive, or both? Additive How do additive fixatives fix tissue? Chemically link to tissue; become part of the tissue by changing it How do nonadditive fixatives fix tissue? Act on tissue, but don't change it How do coagulant fixatives fix tissue? Precipitate proteins to create a network in tissue that is more easily penetrable How do noncoagulant fixatives fix tissue? Do not precipitate proteins but bonds with tissue Factors affecting fixation Temperature Size Volume ratio Time Fixative Penetration Storage pH Osmolality Simple aqueous fixatives Acetic acid Formaldehyde Glutaraldehyde Osmium Tetroxide Picric Acid Nonaqueous fixatives Acetone Alcohol