BUFFERS AND BUFFERING
SYSTEMS (ROLE OF KIDNEY)
, RENAL CONTROL OF ACID BASE BALANCE
• Can eliminate large amounts of acid
• Can also excrete base
• Can conserve and produce HCO3- ions
• Most effective regulator of pH
• Adjust H+ ion concentration to normal
• It is a slow mechanism that works over a period of hours to several days, but
mechanism.
• If kidneys fail, pH balance fails.
Renal regulation occurs through 3 basic mechanisms:
Secretion of H+ and urine acidification at pH 5.0
Reabsorption of filtered HCO3-
Production of new HCO3-
SYSTEMS (ROLE OF KIDNEY)
, RENAL CONTROL OF ACID BASE BALANCE
• Can eliminate large amounts of acid
• Can also excrete base
• Can conserve and produce HCO3- ions
• Most effective regulator of pH
• Adjust H+ ion concentration to normal
• It is a slow mechanism that works over a period of hours to several days, but
mechanism.
• If kidneys fail, pH balance fails.
Renal regulation occurs through 3 basic mechanisms:
Secretion of H+ and urine acidification at pH 5.0
Reabsorption of filtered HCO3-
Production of new HCO3-
