Pharm 1

Pharm 1 affinity - attracted to a receptor potency - amount of drug needed to produce and effect efficacy - how effective the drug is enteral - taken through the GI tract Paraenteral - anywhere but the Gi tract (IV) Cholinesterase inhibitors - Cholinomimetic, Indirect acting Inhibits the break down of ACH broad effects- heart smooth muscles, ANS, adrenal medulla, glands Can cause muscles to contract and not relax causing death (Nm) Bethanechol - Cholinomimetic, Direct acting muscarinic only heart glands and GI GU bronchoconstriction Vecuronium - Anticholinergic, Nm antagonist, Competitive causes flaccid paralysis Succinylcholine - Anticholinergic, Nm antagonist, noncompetitive Causes flaccid paralysis Atrophine - Antimuscarinic increases hr and ctx decreases GI GU bronchodilation gland secretion glycopyrrolate - Antimuscarinic increases hr and ctx decreases GI GU bronchodilation gland secretion Tiotropium - Antimuscarinic inhaled to bronchodilate respiratory drug treats COPD Amphedamines - Sympathomimetic, Indirect increases nor epi availability Non selective direct acting sympathomimetics - combines effects of all receptors ( A1 A2 B1 B2) phenylephrine - Sympathomimetic, Selective, Direct acting, Alpha 1 agonist increase SVR by vasoconstrict dolbtamine - Sympathomimetic, Direct acting, selective, Beta 1 agonist increases CO by HR and CTX also treats systolic CHF, positive inotrope, albuterol - Sympathomimetic, Direct acting, selective, Beta 2 agonist Bronchodilator ( inhaled) respiratory drug, fast acting Prazosin - sympatholytic, alpha 1 blocker vasodilator, decrease BP also an antihypertensive AND effect Lisinopril metoprolol - Sympatholytic, beta 1 antagonist decreases CO also an antihypertensive ANS effect also treats systolic CHF by decreasing workload, and angina prectoris Atenolol - Sympatholytic, beta 1 antagonist decreases CO also an antihypertensive ANS effect also treats systolic CHF by decreasing workload, and angina pectoris Labetalol - Sympatholytic, Alpha 1 and Beta 1 antagonist decreases CO and SVR also and antihypertensive ANS effect Epi ( BP influence) - pressor agent, increases CO and SVR Nor epi ( BP influence) - pressor agent, increases CO and SVR Phenylephrine (BP influence) - pressor agent increases SVR Vasopressin - Pressor agent, increases SVR and CO Lisinopril - Antihypertensive, ACE inhibitor, No ANS effect blocks renin angiotensin converting pathway decreases CO and SVR Losartin - Antihypertensive, ARB, No ANS effect blocks renin angiotensin converting pathway decreases CO and SVR Amlodiphine - Antihypertensive, calcium channel blocker blocks Ca from entering heart = decrease CO vasodilation= decrease SVR Hydrochroathaizides (HCTZ) - Look diuretic blocks Na reabsorption from kidney side effects Furosemide (LASIX) - Loop Diuretics, block Na reabsorption side effects Manitol - osmotic diuretic, given through an IV glucose attracts water to them be excreted. Doesn't block NA Degoxin - Treats systolic Congestive Heart Failure, positive inotrope increases contractility by increasing intercellular Ca in heart. No ANS effect ACE inhibitors - Treat systolic CHF by decreasing myocardial workload decreased BV= decreased preload= decreased workload decreased SVR= decreased afterload= decreased workload and is an Antihypertensive (lisinopril) ARBs - Treat systolic CHF by decreasing myocardial workload decreased BV= decreased preload= decreased workload decreased SVR= decreased afterload= decreased workload and is an Antihypertensive (losartin) Loop Diuretics - Decreases Na in body (furosemide) Treats systolic CHF by decreasing myocardial workload decreases BV= decreased Preload= decreased workload Sacubitril/Valsartin - neprilsin inhibitor (increases urination) and ARB (vasodilated and decreases BV)= entresto decreases preload and afterload to decrease workload. Calcium channel blockers - Antihypertensives (amlodipine) and treats diastolic CHF, and angina pectoris negative inotrope and chronotrope and vasodilator Nitroglicerin - Nitrate-vasodilator, decreases venous return and preload, drugs that treats angina pectoris. Rapid response Isosorbide - NItrate-vasodilator, decreases venous return and preload, either dinitrate or mononitrate. treats angina pectoris. ranolazine - CCB that treats angina pectoris. decreases CA available to decrease myocaridal workload warfarin - Anticoagulant, blood thinner, decreases available K to stop clotting cascade heprin - anticoagulant, blood thinner, prevents thrombin from clotting cascade Rivaroxaban - Anticoagulant, blood thinner, inhibit factor x Apixaban - anticoagulant, blood thinner, inhibits facotr x dibigitban - anticoagulant, blood thinner, inhibits thrombin, direct Asprin - antiplatelet drugs, blood thinner, prevents stroke Clopidogel - antiplatelet drug, blood thinner , prevents stroke tissue plasminogen activator (tPA) - thrombolytic/fibrinolytic, dissolves clots, prevents fibrin lattice and clot dissolution pathway. dissolves good clots too Salmaterol - Respiratory drug, bronchodilator, slow acting, preventative. Affinity, Theuphlline - respiratory bronchodilator methylxanthines Fluticasone - respiratory, anti-inflammatory, corticosteroid, does NOT bronchodilate Montelukast - anti-inflammatory, leukotriene antagonist, taken orally, blocks receptors cromolyn NA - antiinflammation respiratory drug, stops mast cells from releasing pro inflammatory chemicals