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(Lanoxin) is a cardiac glycoside that increases
contractility (positive inotropic effects) and decreases
heart rate (negative chronotropic effects). It is used to
treat atrial fibrillation because, at therapeutic levels
(0.5-2.0 ng/mL), it decreases conduction through the
sinoatrial node (SA) and ventricular heart rate.
However, drug toxicity is common due to digoxin's
narrow therapeutic range. Clients are instructed to
recognize and report signs and symptoms of toxicity
to the health care provider (HCP), including the
following:
Gastrointestinal symptoms, including anorexia,
nausea, vomiting, and abdominal pain, are
Digoxin frequently the earliest symptoms (Option 1).
Neurologic manifestations include lethargy, fatigue,
weakness, and confusion. Visual symptoms are
characteristic and include alterations in color vision,
scotomas, and blindness (Option 3).
Cardiac arrhythmia is the most dangerous symptom.
Digoxin toxicity can result in bradycardia and heart
block, which can cause dizziness or lightheadedness.
Clients are instructed to check the pulse and tell the
HCP if it is low or has skipped beats (Option 2).
(Option 4) There is no need to routinely check blood
pressure before taking the medicine. This client should
be instructed to check the pulse and withhold digoxin if
,the heart rate is <60/min.
Educational objective: Clients receiving digoxin are
instructed to measure their pulse before taking the
medication and withhold digoxin if their heart rate is
<60/min.
Clients should also be taught to recognize and
report signs and symptoms of digoxin toxicity (eg,
anorexia, nausea, diarrhea, lethargy, confusion,
cardiac arrhythmias, visual changes) to the health
care provider.
, The following should be taught to clients taking tetracyclines
Take on an empty stomach - for optimum absorption,
tetracyclines should be taken 1 hour before or 2 hours
after meals (Option 3)
Avoid antacids or dairy products - tetracyclines should
not be taken with iron supplements, antacids, or dairy
products as they bind with the drug and decrease its
absorption (Option 1)
Take with a full glass of water - tetracyclines can cause
pill-induced esophagitis and gastritis; the risk can be
reduced by taking with a full glass of water and
tetracycline
remaining upright after pill ingestion
(eg, tetracycline, doxycycline,
minocycline):
Photosensitivity - severe sunburn can occur with
tetracycline. The client should use sunblock (Option
5).
Medications such as tetracycline and rifampin can
decrease the effectiveness of oral contraceptives;
additional contraceptive techniques will be needed
(Option 4).
(Option 2) Tetracycline taken at bedtime has been
associated with esophageal irritation and stricture
development as it increases reflux of the gastric
contents into the esophagus. This can be prevented by
taking the medicine with plenty of water and during
the day when upright
Educational objective: Tetracyclines should be taken 1
hour before or 2 hours after meals with plenty of water.
They should not be taken with dairy products or within 2
hours of taking antacids. Clients should use sunblock
due to photosensitivity and plan to use additional
contraceptive techniques.