13/06/2025, 13:53 NUR 641E Final Exam QUESTIONS WITH COMPLETE SOLUTIONS (100 % CORRECT AND VERIFIED) ALREADY PASSED!! F…
NUR 641E Final Exam QUESTIONS WITH
COMPLETE SOLUTIONS (100 % CORRECT AND
VERIFIED) ALREADY PASSED!!
Save
Terms in this set (247)
from the administration site either directly or indirectly
Absorption
into the blood/plasma
Reversibly or irreversibly move from bloodstream into
Distribution
the interstitial and intracellular fluid
Biotransformed via hepatic metabolism or by other
Metabolism
tissues
Lastly, the drug and its metabolites are eliminated
Elimination
from the body
-highest bioavailability
IV -bypasses absorption
-avoids first pass in the liver
rectal -erratic and variable absorption
4-5 SS achieved in _-_ half lives
-how long it takes for drug to be excreted from the
body
Half-life
-determines frequency of administration
-predicts how long toxic effects can last
first-order (linear) metabolism is directly proportional to the free
pharmacokinetics concentration of the drug
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,13/06/2025, 13:53 NUR 641E Final Exam QUESTIONS WITH COMPLETE SOLUTIONS (100 % CORRECT AND VERIFIED) ALREADY PASSED!! F…
zero-order (nonlinear) drug is metabolized at a constant rate per unit of time
pharmacokinetics
may have decreased activity if any CYP3A4 inducer
CYP3A4 substrates
drugs are used along with it
Discovery laboratory research to develop the new drug
Preclinical research animal testing for safety
clinical research on healthy human subjects to assess
Phase I
medication PK
clinical research in humans primarily for medication
Phase II safety usually in a population for which the treatment
is intended
clinical research in humans comparing the new drug
Phase III to accepted medications or placebo for efficacy and
safety
post marketing surveillance. Reporting of adverse
Phase IV
effects not identified in earlier clinical studies
-ISMP
-IOM
medication safety
-Joint Commission
organizations
-NCC MERP
-FDA Safe Use Initiative
-80-90% of ADRs
-an extension of the pharmacological affect of the
pharmacological ADR
drug
-ex. overdose
-separate from the pharmacological affect of the
idiosyncratic ADR drug
-commonly immune mediated response
the FDA does/does not mandate that ADRs be
does not
reported
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, 13/06/2025, 13:53 NUR 641E Final Exam QUESTIONS WITH COMPLETE SOLUTIONS (100 % CORRECT AND VERIFIED) ALREADY PASSED!! F…
involves using multiple health care providers for care,
Polypharmacy using multiple medications, and using several
pharmacies for prescription filling
-Lisinopril, captopril, enalopil, ramipril, benazepril,
ACEI fosinopril
-suppress the release of ACE
-cough
ACEI (side effects) -angioedema
-discontinue the ACEI if angioedema occurs
ARBs -block angiotensin II receptors
-denotes high blood pressure from an unidentified
primary hypertension cause; also called essential hypertension
-90% of cases
-high blood pressure caused by the effects of another
secondary hypertension disease
-example: chronic renal failure
-IV/SL/topical/transdermal
Nitroglycerin
-contraindicated with PDE-5 inhibitors
nitrates (contraindications) sildenafil, verdenafil
-antiarrhythmic of choice with coexisting heart failure
amiodarone
-can cause thyroid and pulmonary toxicity
-vasoconstriction
alpha-1 stimulation
-increased blood pressure
-vasodilation
alpha-1 blockade
-reduced blood pressure
-increased HR
beta-1 stimulation -increased BP
-increased CO
-reduced heart rate
beta-1 blockade -reduced BP
-reduced CO
https://quizlet.com/1054012981/nur-641e-final-exam-questions-with-complete-solutions-100-correct-and-verified-already-passed-flash-cards/?new 3/20
NUR 641E Final Exam QUESTIONS WITH
COMPLETE SOLUTIONS (100 % CORRECT AND
VERIFIED) ALREADY PASSED!!
Save
Terms in this set (247)
from the administration site either directly or indirectly
Absorption
into the blood/plasma
Reversibly or irreversibly move from bloodstream into
Distribution
the interstitial and intracellular fluid
Biotransformed via hepatic metabolism or by other
Metabolism
tissues
Lastly, the drug and its metabolites are eliminated
Elimination
from the body
-highest bioavailability
IV -bypasses absorption
-avoids first pass in the liver
rectal -erratic and variable absorption
4-5 SS achieved in _-_ half lives
-how long it takes for drug to be excreted from the
body
Half-life
-determines frequency of administration
-predicts how long toxic effects can last
first-order (linear) metabolism is directly proportional to the free
pharmacokinetics concentration of the drug
https://quizlet.com/1054012981/nur-641e-final-exam-questions-with-complete-solutions-100-correct-and-verified-already-passed-flash-cards/?new 1/20
,13/06/2025, 13:53 NUR 641E Final Exam QUESTIONS WITH COMPLETE SOLUTIONS (100 % CORRECT AND VERIFIED) ALREADY PASSED!! F…
zero-order (nonlinear) drug is metabolized at a constant rate per unit of time
pharmacokinetics
may have decreased activity if any CYP3A4 inducer
CYP3A4 substrates
drugs are used along with it
Discovery laboratory research to develop the new drug
Preclinical research animal testing for safety
clinical research on healthy human subjects to assess
Phase I
medication PK
clinical research in humans primarily for medication
Phase II safety usually in a population for which the treatment
is intended
clinical research in humans comparing the new drug
Phase III to accepted medications or placebo for efficacy and
safety
post marketing surveillance. Reporting of adverse
Phase IV
effects not identified in earlier clinical studies
-ISMP
-IOM
medication safety
-Joint Commission
organizations
-NCC MERP
-FDA Safe Use Initiative
-80-90% of ADRs
-an extension of the pharmacological affect of the
pharmacological ADR
drug
-ex. overdose
-separate from the pharmacological affect of the
idiosyncratic ADR drug
-commonly immune mediated response
the FDA does/does not mandate that ADRs be
does not
reported
https://quizlet.com/1054012981/nur-641e-final-exam-questions-with-complete-solutions-100-correct-and-verified-already-passed-flash-cards/?new 2/20
, 13/06/2025, 13:53 NUR 641E Final Exam QUESTIONS WITH COMPLETE SOLUTIONS (100 % CORRECT AND VERIFIED) ALREADY PASSED!! F…
involves using multiple health care providers for care,
Polypharmacy using multiple medications, and using several
pharmacies for prescription filling
-Lisinopril, captopril, enalopil, ramipril, benazepril,
ACEI fosinopril
-suppress the release of ACE
-cough
ACEI (side effects) -angioedema
-discontinue the ACEI if angioedema occurs
ARBs -block angiotensin II receptors
-denotes high blood pressure from an unidentified
primary hypertension cause; also called essential hypertension
-90% of cases
-high blood pressure caused by the effects of another
secondary hypertension disease
-example: chronic renal failure
-IV/SL/topical/transdermal
Nitroglycerin
-contraindicated with PDE-5 inhibitors
nitrates (contraindications) sildenafil, verdenafil
-antiarrhythmic of choice with coexisting heart failure
amiodarone
-can cause thyroid and pulmonary toxicity
-vasoconstriction
alpha-1 stimulation
-increased blood pressure
-vasodilation
alpha-1 blockade
-reduced blood pressure
-increased HR
beta-1 stimulation -increased BP
-increased CO
-reduced heart rate
beta-1 blockade -reduced BP
-reduced CO
https://quizlet.com/1054012981/nur-641e-final-exam-questions-with-complete-solutions-100-correct-and-verified-already-passed-flash-cards/?new 3/20
