Procedure: Literature review Aim: To review studies into the relation
A variety of sources were used that investigated the between levels of neurotransmitters of
neurochemical levels in patients diagnosed with of schizophrenia.
schizophrenia. Used studies into drugs that are Two main areas of focus were:
known to induce symptoms of psychosis.
• The hyperdopaminergic expla
Additionally, evidence from brain scans that schizophrenia
focused on dopamine levels and psychosis were Contemporary • The hypoglutametergia explan
used. Research into the effects of recreational Clinical- schizophrenia
drugs, like PCP and amphetamines, were examined.
Schizophrenia
The effectiveness of antipsychotics to treat
schizophrenia and the method of action they have Carlsson et al
on the brain. Results:
(2000) Low Glutamate- reduced levels of gluta
associated with increased dopamine pr
Conclusion:
PCP that inhibits glutamate release app
The development of drugs: More research needs
cause schizophrenic symptoms.
to be conducted in developing drugs to treat
High Dopamine- high levels linked to sc
schizophrenia that avoid negative side effects.
symptoms.
Consider role of other transmitters in development
Negative symptoms- evidence suggesti
of disorder.
“Glutamate failure in the cerebral corte
Different types of schizophrenia: Different types
to negative symptoms.
caused by abnormal levels of different
Positive symptoms- Evidence suggestin
neurotransmitters and not just dopamine.
glutamatergic failure in the basal gangli
responsible for positive symptoms.
A variety of sources were used that investigated the between levels of neurotransmitters of
neurochemical levels in patients diagnosed with of schizophrenia.
schizophrenia. Used studies into drugs that are Two main areas of focus were:
known to induce symptoms of psychosis.
• The hyperdopaminergic expla
Additionally, evidence from brain scans that schizophrenia
focused on dopamine levels and psychosis were Contemporary • The hypoglutametergia explan
used. Research into the effects of recreational Clinical- schizophrenia
drugs, like PCP and amphetamines, were examined.
Schizophrenia
The effectiveness of antipsychotics to treat
schizophrenia and the method of action they have Carlsson et al
on the brain. Results:
(2000) Low Glutamate- reduced levels of gluta
associated with increased dopamine pr
Conclusion:
PCP that inhibits glutamate release app
The development of drugs: More research needs
cause schizophrenic symptoms.
to be conducted in developing drugs to treat
High Dopamine- high levels linked to sc
schizophrenia that avoid negative side effects.
symptoms.
Consider role of other transmitters in development
Negative symptoms- evidence suggesti
of disorder.
“Glutamate failure in the cerebral corte
Different types of schizophrenia: Different types
to negative symptoms.
caused by abnormal levels of different
Positive symptoms- Evidence suggestin
neurotransmitters and not just dopamine.
glutamatergic failure in the basal gangli
responsible for positive symptoms.
