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(A-level) AQA Biology Inheritance Topic Summary

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In-depth summary for content covered in the Inheritance topic of A-level AQA Biology, including content covering genes and alleles, punnet squares, monohybrid and dihybrid inheritance, codominance, epistasis and more. This will still be applicable to other exam boards, but take caution when looking at key-words and the order of specific processes. NOTE: a colour code (and use of italics) is used for keywords and expressions in the document, in some documents this may be consistent throughout but for longer documents I have uploaded only the first pages may act as an example of this - giving you opportunity to work through and apply your own colour coding.

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Oliver Dyson


Inherited Change (17)

Genotype and Phenotype:

Genotype is the genetic make-up of an organism

-> involving all the genes and alleles it has

 This determines the limits characteristics of an individual
 Excluding the effect of the environment – e.g. diet

Phenotype is the observable characteristics of an organism

-> therefore, influenced by both environment and genotype

Genes and Alleles:

A gene is a length of DNA / sequence of nucleotide bases

-> these code for the 1o structure of a polypeptide or functional RNA

 Genes exist in different forms, coding for variations of the same structure
 Due to different sequence of bases
 These are called alleles

The position of a gene on a strand of DNA is known as a locus

-> all of these features influence the inheritance for the offspring of an organism

 Only one allele of a gene can occur at a specific locus of a chromosome
 However, in diploid organism (2 chromosomes)
 Homologous pairs of chromosomes mean there are two alleles for the same gene

These can be of a few variations –

1. Homozygous – two of the same alleles carried; either dominant or recessive usually
2. Heterozygous – two different alleles carried

Heterozygous characteristics are usually determined by a
dominant allele

-> these express themselves over their recessive
counterpart

 Usually represented by alternating letters e.g. Bb

, Oliver Dyson


Notation for genetics:

Genetic crosses are usually represented by using standard shorthand

-> this is described by the table below




Figure 1 – reproduced from [1]

Monohybrid inheritance: (e.g. in pea pod colour)

Monohybrid describes the inheritance of a single gene

-> for example pea pod colour can be modelled

 The colour green is dominant – GG or Gg
 And yellow is recessive - gg

Each generation of inheritance is called a ‘filial’

 For example the first filial is called the F 1 generation
for shorthand
 The notation for this is shown on the right Figure 2 – reproduced from [1]

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