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Summary AQA ALEVEL BIOLOGY NOTES ON ANTIBODIES

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ALEVEL NOTES ON THE IMMUNITY TOPIC- ANTIBODIES ADJUSTED TO THE AQA SPECIFICATION AND MADE FROM MARKSCHEMES

Institution
AQA

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Antibodies
What are antibodies ?


cells / secreted plasma cells
produced by
B by .




→ Antibodies are proteins specific to an antigen

body infected self material specific
-
When the is
by non -
,
a B cell produces a
antibody .




The

Each
antibody has two identical binding sites .

antibody binding sites are
complementary to

a specific antigen .




Antibody structure %
xnxx.vn#x-xE
antigen
"
Antibodies proteins and made of four
µ µ
-



are are


polypeptide chains .




{
-


of
The
specificity antibody depends its
-

an on

\
GO
-

variable
regions ,
which form the
antigen binding
} g. r light
sites .


variable n chain
-


All antibodies have the same constant
regions .
regions -
r


has
-
Each antibody variable with disulfide
a
region a





bridge
unique tertiary structure ( due to different hinge
) that's region
amino acid sequences complementary r
> heavy
to one
specific antigen .
constant chain
'
The chains of one pair are
long and are called regions ( blue)


heavy chains ,
which the chains of the other pair are



shorter and chains
are known as
light .




Each
antibody has specific that fits precisely onto specific
a
binding site very
a





antigen to form what is known as an
antigen antibody -


complex .




Antibody Function
←ÉÉ¥
It is
important to do not directly but rather
understand that antibodies
destroy antigens





the for destruction
prepare antigen .




destruction in two
Antibodies assist in a
pathogen 's ways
:





Agglutination

It Clumps of bacterial cells formed
making it easier for the phagocytes
'

are ,




the
to locate them as
they are less spread-out within body .




yy.y.y.gg •




to
Agglutination
two pathogens
occurs as


at
an


the
antibody
s am e time
has

.
two binding sites ,
so it can bind




Antibody organisation

µ
µµ ✗ by which destruction
Opsonisation is process pathogen marked
by
.

a a is .




They markers that stimulate
phagocytes to
engulf the bacterial
'

e- serve as

cells to which attached
Y they are .




Y y

- Ariki

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