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Lecture notes

Sarcoidosis

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A complete overview of an autoimmune disease known as Sarcoidosis.No boring slides plus i added few pictures related to disease you going to love.

Institution
St Georges
Module
Medicine









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Written for

Document information

Uploaded on
November 18, 2022
Number of pages
5
Written in
2022/2023
Type
Lecture notes
Professor(s)
Olena
Contains
Sarcoidosis

Subjects

Content preview

of
Sarcoidosis -
a inflammatory disease
marked
by the formation granulomas
in the
vgarious body organs
.




Etiology :L stimulus Antigen
in
come

contact
↓ •

Antigen of previous exposure
_

with
Environmental maoothYemaoopn.ge
or dendritic
dendritic

712A mutation → Mycobacterium tuberculosis ce ,
,
cell

gene → Borelliabumdogferictyme disease )
→ HHV -8 +12Agene
mutation
"
cell → P.
aches
6 go .




"ᵗᵈ chromosome
-




c pleomorphism
pÑ☒Ñ
'




inside lymfhnode Lymbhrode "
onion
stir
""
phagolysosome

\
'
§
-




HcI
tar


lead#
goenintotfmt.hn -
A ⑨•
⑨ phagosome
This interaction cytokines • Ima 0¥ Antigenic ,#
of certain mug,
releasing MHC OFMHC
like -1-2-2 formation
multinucleated gig:&
complex ☆•⑥

g- cells
proliferation release cytokines
••-
lysosome
.




⑤ they activate "
• like IFN-8
-




TNF 9
which further
-




cytoplasm

fibroblast

! attract
Lymphocyte
IFN-tg.ph?g
more




[↓

release macrophage lymphoblast
,
g-used •
ask

and fibroblast .


/* _ efhitheloid
man




÷:/
gaga ,
macrophage cell

ebhitheloid
*
Astroid Canaan # Homma - non


caseating

, → granulomas deposit into different body tissues .




in brain
in
eyes inbarotidgland
Parotitis
diabetes
insipidus Anterior or parotidgland facial nerve baby
[ granuloma deposition post -
Uveitis
ADH
hypothalamus so no ↳ facial nerve

production ) Heerfooidt 's
-

Hypopituitarism syndrome
in
myocardium in Liver inyoints
ebatosplenomegaly
→ restrictive cardiomyocandiobathy nthnaegiq


aooythmiacifgno.nu/omaformnisinAVnodeisAnode)

pericarditis
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