OfC.'~~,:i ~~ i:"tw~,601( c; ,t a.it
1
0.-.1~~~ ."~~i;.~~~UIAR .__ sqn thtli$! I 1orqr,
..J
alltnal< 'I mctoboUc
ttOt\iOIU +, bra1091ral
r'
tnnt •~
itttrm1nu (nrl!r'MI
0 H01 Nfn
t< 1111·•
tQ~C~lf a
tt~lnuovJ
dt IIon ,
~
CO al Stl
tr d ~'
l'ft~,c fnQ ,ni1111111 INB~ GIINI C
~ ,
l ,~~
- •I ,
mrta~UtrJ
o broK•"
\UmG 1der~· ned ~orm ~ ~ tt" 1.. . . ., tr •• '""'""'
MUV'
•
moltCUltJ
cataH sts ftmmon (ntn 'IHIM var1auori1ntnc , •• ,, 1\ • rl r • "vu
~
p1t'1n~1tlbnormOI ,-)
►h<t~
s,-al>IC
I 1.1 ~llbnonw ~, !f'°'s'ti~Ai.~(l~mino Mid protein pioduttion 01 the numbt r 09 r<Ottonr, Al prodocts • "'"1
,
~\?.l}lJCi rnu1m, NO~,~~~i~~u'~~r-~r11', \r~u,n<A ffl"<1i11r,uM the ] " wi,1c1i liOCtrons tOtOl~~d
( ptrsccond ~
tu'tr"~~rlo
intcrmcd10\U 5
'tna•
at~Vlt\f • tnf\jrn(' IN~ll81TQIU adtfitftn d1'1t(1~.~1\arn '" 1~ ·1\',,',(",~Sl"'•t i,r,m(lOboUGM IJl"1Cll.tl "u''i m\~ml' th· u.c111t1e"'~ !l'"'.!!!ts
rJ Qt Q tff~~ tf l '
~ou1dl r '' I "
t rf 111rcn t11111r ~ 11 l'lljf lln\lnot1n9 CQI rt
t~(,IJ ltvtU 'f(nl~m•
ca ,~ton oe~
tQlltn ,n(I h4'1( r d1Hilf7dc Q(Tf -
,ntll · , ~
compttttl V't tht rn,10-uc \ t '11 t dt!>fndlnQ on) corw 1nlo · scd the • ' .. • ,. ••
♦nr
1•
. it0ttttt1\lo1o1, eut:iit~~u~ti spttd up con bt u
innl\.ltror 1-tOOlH.
A~ S~llQ.\ COl'f\l)f~t ~~tho
d1$of\ltt to0W
ttlU :~:~ nt
'amran ~ Nl'II b(nd It {o
W(f(¥ ''
' 'lfh~ mttliboll' need {
....,..('f~r1ln1m~~(1(\ oc1uu • don't l't'\Q~( p ' / ChtmitOI oga,n •
dtttn-nincs
· foNCT10Nc.f thC me
$1Jbl h'OIC NIOlctWl
pos1'tiQ n OI'\ M\t~ s,,,,tot.,... tn't~Nlt•
~f>ltlC
lnhibit1' ti
oru',ontn'cSI
t<l ' ,;hn<" •i \cir Ml~tClktl
biOIOq(tOI
COtQll.tS"
lit.
lfOCtiOnl } N01 ALL
PA0Ti.11'&S AAt
"-. tntll
)
v~t~
~UbM~tt )
I Sitt. inhibltJ~ttN°~ Ot~~ •• •~~~~i~Uhl ~ !.~~y~t
--··•r
rQtt r ~~~PJ~r,~~Hdt
ln,tea llj, ~ntq111t•
t t1~~:~~ts.) t~a1te~~~ui~
~ICSS\htl (r \.,_ ornan1~r(\S
(arr:i~i~~d~aarqed
OCtl On
J lNt'1ME..S
-
,co_iJ~~=-'~~f1t ~·
b st tt.
su ro
·
\l1nlbi ttrr pl{Stnct
'P'"'""t inn1arorJ
\ f suiostro~ co~-
subttrottQttmCl-ln9
random•~ ""-
,xtrtro' p\4 · "l
unUKt rot!ll41t, LOr1EA 1HE
""' 1't
__,,
... • ,~
11
.... ,.,, . ..... -- . -
ltru~tutt wh,ch
n,qut TO ( OC
h•s
·ndln<) to tnl~RJ( ,l, tnis tfftct bot """ _,.,,,......
I Pt'('ltnts CZ>Ub~~rott bi not ~tom to non- coroP· . rolt\lltt( '~~ctMI L ra}~stisr ACTIEVATI..°;~ ._,.. ~~) \.mode,., 100 to I ooo.ooo ent."!me
~ numt:itrq. us,nci st"Pttt ✓• ' ' ~ NE... 1 v'"~"'"' . "r ,:..i ·
ft« mt~mc, availabl<
1nhibttonou
'-, in\"liut<m~ ~ pon 'l ~111pt1
OYH
"'p111d._ _________ rl mQlt ·r PROIIIIC om,no ac,ds Qrran'j"u in 0
einoinq tan bt't,-.~\.\rn'-SUbstm~ tl'lt (rRAt>1Et11 ~ A'5,-.\All SP~~~~ ~pecifiC Chain ~tq~ncc
ChotM!t1ifl HoutOf MODULE :l· I. RtCi\01'\cf.t~, (O~l4fl1 ldeter:m1ntdbt
IJ~=~
QEVE~SISl! COO'lplC~
f tht Qctt~
CfUSttt around
int~rt,~ witr\ tht
Jvf'fl41m
ntgauwt R 9n,up + l"s,rt ~='1ru1::;an,i,
1 .intt'ltttJ with
Htions-: in 1
,(lnlc t)on s + Qltf'r
SnQpc"th~ •
Achanqc io ti
a~ EN ZY E A(1 ION IMI
ent4mc pOrtit!POta dont
ii\ tht c~tolqJ1J Cf
b'Othtm•CQI
, ttottion.r
b -procfo,
entq~ s" ud:t txtrcicetluld(
<Jrne1 '" th, t<1
E.nt4mr1 C'an be intrQC(IIUIOf or
.,,...J
~ound 7
S1NDIN~cttf!C. '-..__
S':Je.5'T~-retoo.cti...e' potiti"Chorqt""-..,, I • l - - - - - - -....-::-:, 11o,tOP I S } .·.highl~ ours EU.llJ if)thc 1-!ITt-HN CELlS
+vt hJ &orq~ .J pU Storr = \ S,:,cclflC '0 cytoPIOSm r'
s,tt
H1'i~o~OTtrttcttdtO
-~• 'I charqcd porc;tlCJ +
buf~~fton
moi~1J>n'rt~s a
LO(;ARITl•lf•IIC .. ~ Po~u-Cf
a 1ar9c conccntrut.icn . . hijd roqe.o
ic! ~ riM in iurtrr«
1 ·,t)t\mtntS ~ J
\
• • • \ indtnt on/ a
.
• -·
l lt •qbloocl,O"r Catatasr:fOUt1d
SI in all or nism.3
Q.E.Pl.AG tht H~ s...M
"-~II chanqt/ ,n ,..... d
coN'TR~ v~1ABI.E
\
1 w ·,or-6 ,rodr
too Small
rnd1ccm'1
i-ihrther a
Shape can,_, th t or
brOff t ti
Cltft oncont1L-
llll"fQ(.( Cf ,,,,...,,~
1 Amu(ast
,
t that Ott z:1posed ro
rnn be ttctifit as . PH \1llur SOiution =oci di c Hrr r / tht rno1tcu1r ~9,rcuie '""' t'l)pSin" Cx'f <rEN
Cardiac foilurt • Jlit~Y~~m~ rfforTW\h<IIJt~mw/)~~~h neutrot or al KOUri t ~ P :roturf \ tit ll'lto t~fl"ft we,~ cm 4 \ (QtOlqm tht
CO2. 1sn•tl(MO-.td . s,tc conacttPt Ot'd ~ ~ ---- ~ SUbSfrOt.t hos CIiis + Ql-t dl'COmpofit;on t.f
anqth•fl9 h4drooen ionr t o ~ containr contoiru "' • AY
0 coMPL£.-1ENTA_ oHcn seoe...ed ( HYOROGEN PEROx,gE
't , ~ ~
lpHc:J biood
ir 1owtttd sUqtn~ a~ \ rtjninK\in o OU-iont H" iont • shape to the Otb\'f to i-t,ltr. Ol~qcn
,~♦ Am4 IQSt ~ pn:JCfuctd lfl
1
" . " ,8~,~~ h~ ,..'-..}l-!,.~n7~ • • ( It protons 'nJ01ecu1CJ ha>tt r s~ prt,dutt c:pnonq
dctomWl101 tffftt,()"l b¢~ • . haJO;JIObin •. ,1 • .., . : £>,g M(l l<.E + rnow l"'k + kt~ SAUl,~RY ut.ANOS mrtabouc l'tactans + is
• •• . •f • ttsistr a dissroater inro r_~QStc.- ~ . d,qutt starCh to harmful
'i -►•
l.
charq, rn the ~ .• ~ • •••• ·~•. \ n:'... ~ G,o ~ tnp/1
COlctJlotes .Cha,ivc ,...._, H·"nct.. ct· 'u~ rL
I hupothtl•
., MQltOSC Cata lose contains '4,.
rote ct ttoct{on rdtt at f trmpe"1fll1t-:- ratcot itu Qcids .. hljdrogri, donors SUCCtJrfu I S } en111me actM
I t • Substrtttt ~~l~ &1~~~ &itc: \ POL't PEPTroE tttA1NS witn
Nhrn the temp. is t blj Q ~rmi:iera "' COUisions ~ocuan in the smau o hacmliron) group
Ff\CTOR ot ,o ent(fmt= thir ma~ brtaK I temp. ) 1h~ c~mp1rmtn101tf \.. intttunt ottoched ? .
Prottasr:
OPuntun,pH~ rot_c ~ dr,,aturCd •
')tOPSr~'"'"'l
':>OmcCftht wtalr ·
h~d111qw ·~·"
1O
,rjou V COUi&1ons1s f c:: 11\JJU!t lt\
H:
h
fo_r(:tC{
·s tr
_P , 1 11'1:n,odtrn
. th~NCQEAJ •OtrJ OEFIC!fNCy
a11ows1Ho
bind _,, hljdldj!
Ls W°"<f, i'rl l'tactor, Cort
5T0'1t'lc+Hc be ca/Corot-ed
"'ondJ hold, nq heat couser
tht nRnARY'\' mo1tcurr110 If ~octant
(.'-:-'. up C\ tl..
'" ,,1 1
•n tht Jn'l(lll
inttftine to diqe1t
O ru1t i
C fl tt n
PU'O'(ldt
\>'1'0t btJ di'fid ing1 iftrniperan,,e.. ~tt'llctuttin lvr8Rf\T£mo,t' eonta,nsan _ \af tl\'CSittHDlOf P~~tin_... brt'.<llCPCptidc onfn-sk~ tasrievtis
~zn.r 0 b(J the time it 100 ,-1,c,H tnt ~ Place EN-ZYHE - ro.tecr ,tsrlf around tht bond.s ,rnorma11 ti.,~ell '"\.(Qta tim(
'$rnllll~': toke/ to ttach Orli.t' site , ' - C!1lfJ.jcr St-ape Cf entljmr- SUbJhttt(
••• \'OU SUbstrotc to qi~ . lo~'%i~ p~ diObetcf ~EJ~~s:,~~h,d I
'1 Pept;dr anrndpoin~ IRR£VfRS18lY • '.' complexer i
Of rt ClCti~ Qbttl".fCOl'T\pltrnfrtaf\!~1t 1 • 'l I ,ll~~·h4droqcn
......0
mc4ccultJ rha~r1 so Wbstn:itc can no T proouc,nq Q sta'o" P(ro)i"d'
"'1
tonger bind tnt~mr-«:aubStl'Utt complo 1
1
0.-.1~~~ ."~~i;.~~~UIAR .__ sqn thtli$! I 1orqr,
..J
alltnal< 'I mctoboUc
ttOt\iOIU +, bra1091ral
r'
tnnt •~
itttrm1nu (nrl!r'MI
0 H01 Nfn
t< 1111·•
tQ~C~lf a
tt~lnuovJ
dt IIon ,
~
CO al Stl
tr d ~'
l'ft~,c fnQ ,ni1111111 INB~ GIINI C
~ ,
l ,~~
- •I ,
mrta~UtrJ
o broK•"
\UmG 1der~· ned ~orm ~ ~ tt" 1.. . . ., tr •• '""'""'
MUV'
•
moltCUltJ
cataH sts ftmmon (ntn 'IHIM var1auori1ntnc , •• ,, 1\ • rl r • "vu
~
p1t'1n~1tlbnormOI ,-)
►h<t~
s,-al>IC
I 1.1 ~llbnonw ~, !f'°'s'ti~Ai.~(l~mino Mid protein pioduttion 01 the numbt r 09 r<Ottonr, Al prodocts • "'"1
,
~\?.l}lJCi rnu1m, NO~,~~~i~~u'~~r-~r11', \r~u,n<A ffl"<1i11r,uM the ] " wi,1c1i liOCtrons tOtOl~~d
( ptrsccond ~
tu'tr"~~rlo
intcrmcd10\U 5
'tna•
at~Vlt\f • tnf\jrn(' IN~ll81TQIU adtfitftn d1'1t(1~.~1\arn '" 1~ ·1\',,',(",~Sl"'•t i,r,m(lOboUGM IJl"1Cll.tl "u''i m\~ml' th· u.c111t1e"'~ !l'"'.!!!ts
rJ Qt Q tff~~ tf l '
~ou1dl r '' I "
t rf 111rcn t11111r ~ 11 l'lljf lln\lnot1n9 CQI rt
t~(,IJ ltvtU 'f(nl~m•
ca ,~ton oe~
tQlltn ,n(I h4'1( r d1Hilf7dc Q(Tf -
,ntll · , ~
compttttl V't tht rn,10-uc \ t '11 t dt!>fndlnQ on) corw 1nlo · scd the • ' .. • ,. ••
♦nr
1•
. it0ttttt1\lo1o1, eut:iit~~u~ti spttd up con bt u
innl\.ltror 1-tOOlH.
A~ S~llQ.\ COl'f\l)f~t ~~tho
d1$of\ltt to0W
ttlU :~:~ nt
'amran ~ Nl'II b(nd It {o
W(f(¥ ''
' 'lfh~ mttliboll' need {
....,..('f~r1ln1m~~(1(\ oc1uu • don't l't'\Q~( p ' / ChtmitOI oga,n •
dtttn-nincs
· foNCT10Nc.f thC me
$1Jbl h'OIC NIOlctWl
pos1'tiQ n OI'\ M\t~ s,,,,tot.,... tn't~Nlt•
~f>ltlC
lnhibit1' ti
oru',ontn'cSI
t<l ' ,;hn<" •i \cir Ml~tClktl
biOIOq(tOI
COtQll.tS"
lit.
lfOCtiOnl } N01 ALL
PA0Ti.11'&S AAt
"-. tntll
)
v~t~
~UbM~tt )
I Sitt. inhibltJ~ttN°~ Ot~~ •• •~~~~i~Uhl ~ !.~~y~t
--··•r
rQtt r ~~~PJ~r,~~Hdt
ln,tea llj, ~ntq111t•
t t1~~:~~ts.) t~a1te~~~ui~
~ICSS\htl (r \.,_ ornan1~r(\S
(arr:i~i~~d~aarqed
OCtl On
J lNt'1ME..S
-
,co_iJ~~=-'~~f1t ~·
b st tt.
su ro
·
\l1nlbi ttrr pl{Stnct
'P'"'""t inn1arorJ
\ f suiostro~ co~-
subttrottQttmCl-ln9
random•~ ""-
,xtrtro' p\4 · "l
unUKt rot!ll41t, LOr1EA 1HE
""' 1't
__,,
... • ,~
11
.... ,.,, . ..... -- . -
ltru~tutt wh,ch
n,qut TO ( OC
h•s
·ndln<) to tnl~RJ( ,l, tnis tfftct bot """ _,.,,,......
I Pt'('ltnts CZ>Ub~~rott bi not ~tom to non- coroP· . rolt\lltt( '~~ctMI L ra}~stisr ACTIEVATI..°;~ ._,.. ~~) \.mode,., 100 to I ooo.ooo ent."!me
~ numt:itrq. us,nci st"Pttt ✓• ' ' ~ NE... 1 v'"~"'"' . "r ,:..i ·
ft« mt~mc, availabl<
1nhibttonou
'-, in\"liut<m~ ~ pon 'l ~111pt1
OYH
"'p111d._ _________ rl mQlt ·r PROIIIIC om,no ac,ds Qrran'j"u in 0
einoinq tan bt't,-.~\.\rn'-SUbstm~ tl'lt (rRAt>1Et11 ~ A'5,-.\All SP~~~~ ~pecifiC Chain ~tq~ncc
ChotM!t1ifl HoutOf MODULE :l· I. RtCi\01'\cf.t~, (O~l4fl1 ldeter:m1ntdbt
IJ~=~
QEVE~SISl! COO'lplC~
f tht Qctt~
CfUSttt around
int~rt,~ witr\ tht
Jvf'fl41m
ntgauwt R 9n,up + l"s,rt ~='1ru1::;an,i,
1 .intt'ltttJ with
Htions-: in 1
,(lnlc t)on s + Qltf'r
SnQpc"th~ •
Achanqc io ti
a~ EN ZY E A(1 ION IMI
ent4mc pOrtit!POta dont
ii\ tht c~tolqJ1J Cf
b'Othtm•CQI
, ttottion.r
b -procfo,
entq~ s" ud:t txtrcicetluld(
<Jrne1 '" th, t<1
E.nt4mr1 C'an be intrQC(IIUIOf or
.,,...J
~ound 7
S1NDIN~cttf!C. '-..__
S':Je.5'T~-retoo.cti...e' potiti"Chorqt""-..,, I • l - - - - - - -....-::-:, 11o,tOP I S } .·.highl~ ours EU.llJ if)thc 1-!ITt-HN CELlS
+vt hJ &orq~ .J pU Storr = \ S,:,cclflC '0 cytoPIOSm r'
s,tt
H1'i~o~OTtrttcttdtO
-~• 'I charqcd porc;tlCJ +
buf~~fton
moi~1J>n'rt~s a
LO(;ARITl•lf•IIC .. ~ Po~u-Cf
a 1ar9c conccntrut.icn . . hijd roqe.o
ic! ~ riM in iurtrr«
1 ·,t)t\mtntS ~ J
\
• • • \ indtnt on/ a
.
• -·
l lt •qbloocl,O"r Catatasr:fOUt1d
SI in all or nism.3
Q.E.Pl.AG tht H~ s...M
"-~II chanqt/ ,n ,..... d
coN'TR~ v~1ABI.E
\
1 w ·,or-6 ,rodr
too Small
rnd1ccm'1
i-ihrther a
Shape can,_, th t or
brOff t ti
Cltft oncont1L-
llll"fQ(.( Cf ,,,,...,,~
1 Amu(ast
,
t that Ott z:1posed ro
rnn be ttctifit as . PH \1llur SOiution =oci di c Hrr r / tht rno1tcu1r ~9,rcuie '""' t'l)pSin" Cx'f <rEN
Cardiac foilurt • Jlit~Y~~m~ rfforTW\h<IIJt~mw/)~~~h neutrot or al KOUri t ~ P :roturf \ tit ll'lto t~fl"ft we,~ cm 4 \ (QtOlqm tht
CO2. 1sn•tl(MO-.td . s,tc conacttPt Ot'd ~ ~ ---- ~ SUbSfrOt.t hos CIiis + Ql-t dl'COmpofit;on t.f
anqth•fl9 h4drooen ionr t o ~ containr contoiru "' • AY
0 coMPL£.-1ENTA_ oHcn seoe...ed ( HYOROGEN PEROx,gE
't , ~ ~
lpHc:J biood
ir 1owtttd sUqtn~ a~ \ rtjninK\in o OU-iont H" iont • shape to the Otb\'f to i-t,ltr. Ol~qcn
,~♦ Am4 IQSt ~ pn:JCfuctd lfl
1
" . " ,8~,~~ h~ ,..'-..}l-!,.~n7~ • • ( It protons 'nJ01ecu1CJ ha>tt r s~ prt,dutt c:pnonq
dctomWl101 tffftt,()"l b¢~ • . haJO;JIObin •. ,1 • .., . : £>,g M(l l<.E + rnow l"'k + kt~ SAUl,~RY ut.ANOS mrtabouc l'tactans + is
• •• . •f • ttsistr a dissroater inro r_~QStc.- ~ . d,qutt starCh to harmful
'i -►•
l.
charq, rn the ~ .• ~ • •••• ·~•. \ n:'... ~ G,o ~ tnp/1
COlctJlotes .Cha,ivc ,...._, H·"nct.. ct· 'u~ rL
I hupothtl•
., MQltOSC Cata lose contains '4,.
rote ct ttoct{on rdtt at f trmpe"1fll1t-:- ratcot itu Qcids .. hljdrogri, donors SUCCtJrfu I S } en111me actM
I t • Substrtttt ~~l~ &1~~~ &itc: \ POL't PEPTroE tttA1NS witn
Nhrn the temp. is t blj Q ~rmi:iera "' COUisions ~ocuan in the smau o hacmliron) group
Ff\CTOR ot ,o ent(fmt= thir ma~ brtaK I temp. ) 1h~ c~mp1rmtn101tf \.. intttunt ottoched ? .
Prottasr:
OPuntun,pH~ rot_c ~ dr,,aturCd •
')tOPSr~'"'"'l
':>OmcCftht wtalr ·
h~d111qw ·~·"
1O
,rjou V COUi&1ons1s f c:: 11\JJU!t lt\
H:
h
fo_r(:tC{
·s tr
_P , 1 11'1:n,odtrn
. th~NCQEAJ •OtrJ OEFIC!fNCy
a11ows1Ho
bind _,, hljdldj!
Ls W°"<f, i'rl l'tactor, Cort
5T0'1t'lc+Hc be ca/Corot-ed
"'ondJ hold, nq heat couser
tht nRnARY'\' mo1tcurr110 If ~octant
(.'-:-'. up C\ tl..
'" ,,1 1
•n tht Jn'l(lll
inttftine to diqe1t
O ru1t i
C fl tt n
PU'O'(ldt
\>'1'0t btJ di'fid ing1 iftrniperan,,e.. ~tt'llctuttin lvr8Rf\T£mo,t' eonta,nsan _ \af tl\'CSittHDlOf P~~tin_... brt'.<llCPCptidc onfn-sk~ tasrievtis
~zn.r 0 b(J the time it 100 ,-1,c,H tnt ~ Place EN-ZYHE - ro.tecr ,tsrlf around tht bond.s ,rnorma11 ti.,~ell '"\.(Qta tim(
'$rnllll~': toke/ to ttach Orli.t' site , ' - C!1lfJ.jcr St-ape Cf entljmr- SUbJhttt(
••• \'OU SUbstrotc to qi~ . lo~'%i~ p~ diObetcf ~EJ~~s:,~~h,d I
'1 Pept;dr anrndpoin~ IRR£VfRS18lY • '.' complexer i
Of rt ClCti~ Qbttl".fCOl'T\pltrnfrtaf\!~1t 1 • 'l I ,ll~~·h4droqcn
......0
mc4ccultJ rha~r1 so Wbstn:itc can no T proouc,nq Q sta'o" P(ro)i"d'
"'1
tonger bind tnt~mr-«:aubStl'Utt complo 1
