UWORLD USMLE STEP 1 EXAM |ACTUAL
QUESTIONS AND VERIFIED ANSWERS|BRAND NEW
2026-2027 UPDATE|GRADED A+
Question 1
What do you think when you see
- fatiguability (due to anemia)
- constipation (due to hypercalcemia)
- bone pain, most commonly in the back and ribs (bone lysis due to production of osteoclast-
activating factor by myeloma cells)
- elevated serum protein (monoclonal proteins)
- renal failure
CORRECT ANSWER
multiple myeloma
Question 2
clonal myeloproliferative disease of pluripotent hematopoietic stem cells
- increased RBC mass
- increased plasma volume
- low EPO levels
majority have which mutation, what type is it?
CORRECT ANSWER
JAK1 V617F mutation, non-receptor (cytoplasmic) tyrosine kinase associated with
erythropoietin receptor
1
,polycythemia vera
Question 3
acute onset of
- neurologic abnormalities
- hypoxemia
- petechial rash
in a patient with severe long bone and/or pelvic fractures is strongly suggestive of
CORRECT ANSWER
fat embolism syndrome
most commonly occurs within the first 24-72 hours
Question 4
What is often the first sign you see in Primary biliary cirrhosis?
Who typically presents with this?
CORRECT ANSWER
pruritus
middle-aged woman and is insidious in onset
Question 5
2
,Colonoscopy findings
-reddish/violet, flat maculopapular lesions or hemorrhagic nodules
Biopsy Findings
- spindle-shaped tumor cells with small-vessel proliferation
CORRECT ANSWER
Kaposi's sarcoma
Question 6
Colonoscopy findings
- contiguous area of erythematous, friable, granular mucosa with possible pseudo polyps
Biopsy findings
- inflammatory infiltrate involving the mucosa and submucosa with crypt abscesses
CORRECT ANSWER
Ulcerative Colitis
Question 7
During wound healing, excessive matrix metalloproteinase activity and myofibroblast
accumulation in the wound margins can result in
CORRECT ANSWER
contracture - they produce deformities of the wound and surrounding tissues, most offend
on the palms, soles, anterior thorax or at serious burn sites
Question 8
3
, Which is activated to cause problems?
APC
BRCA1
KRAS
RB
TP53
CORRECT ANSWER
KRAS - activation of proto-oncogenes results in stimulation of cellular proliferation
Question 9
aur rods think
what cytogenic abnormality
CORRECT ANSWER
AML
t(15;17)
translocation between the retinoid acid receptor alpha (RARalpha) gene on chromosome 17
and the promyelocytic leukemia (PML) gene on chromosome 15
codes for an abnormal retinoid acid receptor
management is with all-trans retinoic acid
4
QUESTIONS AND VERIFIED ANSWERS|BRAND NEW
2026-2027 UPDATE|GRADED A+
Question 1
What do you think when you see
- fatiguability (due to anemia)
- constipation (due to hypercalcemia)
- bone pain, most commonly in the back and ribs (bone lysis due to production of osteoclast-
activating factor by myeloma cells)
- elevated serum protein (monoclonal proteins)
- renal failure
CORRECT ANSWER
multiple myeloma
Question 2
clonal myeloproliferative disease of pluripotent hematopoietic stem cells
- increased RBC mass
- increased plasma volume
- low EPO levels
majority have which mutation, what type is it?
CORRECT ANSWER
JAK1 V617F mutation, non-receptor (cytoplasmic) tyrosine kinase associated with
erythropoietin receptor
1
,polycythemia vera
Question 3
acute onset of
- neurologic abnormalities
- hypoxemia
- petechial rash
in a patient with severe long bone and/or pelvic fractures is strongly suggestive of
CORRECT ANSWER
fat embolism syndrome
most commonly occurs within the first 24-72 hours
Question 4
What is often the first sign you see in Primary biliary cirrhosis?
Who typically presents with this?
CORRECT ANSWER
pruritus
middle-aged woman and is insidious in onset
Question 5
2
,Colonoscopy findings
-reddish/violet, flat maculopapular lesions or hemorrhagic nodules
Biopsy Findings
- spindle-shaped tumor cells with small-vessel proliferation
CORRECT ANSWER
Kaposi's sarcoma
Question 6
Colonoscopy findings
- contiguous area of erythematous, friable, granular mucosa with possible pseudo polyps
Biopsy findings
- inflammatory infiltrate involving the mucosa and submucosa with crypt abscesses
CORRECT ANSWER
Ulcerative Colitis
Question 7
During wound healing, excessive matrix metalloproteinase activity and myofibroblast
accumulation in the wound margins can result in
CORRECT ANSWER
contracture - they produce deformities of the wound and surrounding tissues, most offend
on the palms, soles, anterior thorax or at serious burn sites
Question 8
3
, Which is activated to cause problems?
APC
BRCA1
KRAS
RB
TP53
CORRECT ANSWER
KRAS - activation of proto-oncogenes results in stimulation of cellular proliferation
Question 9
aur rods think
what cytogenic abnormality
CORRECT ANSWER
AML
t(15;17)
translocation between the retinoid acid receptor alpha (RARalpha) gene on chromosome 17
and the promyelocytic leukemia (PML) gene on chromosome 15
codes for an abnormal retinoid acid receptor
management is with all-trans retinoic acid
4
