Thursday 4 June 2026 – Afternoon
A Level Biology B (Advancing Biology)
H422/01 Fundamentals of biology
Time allowed: 2 hours 15 minutes
You can use:
* 2 6 6 3 9 0 2 8 8 4 *
• a scientific or graphical calculator
• a ruler (cm/mm)
* H 4 2 2 0 1 *
Please write clearly in black ink. Do not write in the barcodes.
Centre number Candidate number
First name(s)
Last name
INSTRUCTIONS
• Use black ink. You can use an HB pencil, but only for graphs and diagrams.
• Write your answer to each question in the space provided. If you need extra space use
the lined pages at the end of this booklet. The question numbers must be clearly shown.
• Answer all the questions.
• Where appropriate, your answer should be supported with working. Marks might be
given for using a correct method, even if your answer is wrong.
INFORMATION
• The total mark for this paper is 110.
• The marks for each question are shown in brackets [ ].
• Quality of extended response will be assessed in questions marked with an asterisk (*).
• This document has 40 pages.
ADVICE
• Read each question carefully before you start your answer.
© Cambridge OCR 2026 [601/4720/9] Cambridge OCR is an exempt Charity
DC (CJ/TC) 361122/4 Turn over
, 2
Section A
You should spend a maximum of 40 minutes on this section.
Write your answer for each question in the box provided.
1 Which statement about the regulation of blood glucose is correct?
A Decrease in blood glucose concentration is detected by α and β cells of the pancreas.
B Decrease in blood glucose concentration stops the secretion of insulin by α cells.
C Increase in blood glucose concentration is detected by liver cells.
D Increase in blood glucose concentration reduces uptake of glucose by liver cells.
Your answer [1]
© Cambridge OCR 2026
, 3
This is a graph showing an action potential.
40
20
A
0
B
-20
Potential
difference (mV) -40
-60
D
-80 C
0 1 2 3 4
Time (milliseconds)
Use the graph to answer questions 2 and 3.
2 What is the time taken in seconds for repolarisation to occur?
A 5 × 10–4 s
B 0.5 s
C 2.7 × 10–3 s
D 2.7 s
Your answer [1]
3 Which of the points, labelled A to D, on the graph shows where hyperpolarisation is occurring?
Your answer [1]
© Cambridge OCR 2026 Turn over
, 4
4 Neurotransmitters and ions are important in the functioning of a synapse.
Which of the following statements is/are correct?
1 Acetylcholine binds to receptors on sodium ion channels in post-synaptic membrane.
2 Calcium ions cause vesicles of acetylcholine to fuse with pre-synaptic membrane.
3 Sodium ions cause vesicles of acetylcholine to fuse with post-synaptic membrane.
A 1, 2 and 3 are correct
B Only 1 and 2 are correct
C Only 2 and 3 are correct
D Only 1 is correct
Your answer [1]
5 What treatment is not suitable for hypothermia?
A Apply warm pads to neck and chest
B Cover with blankets
C Heat hands and feet as quickly as possible
D Replace wet clothing with dry clothing
Your answer [1]
© Cambridge OCR 2026
A Level Biology B (Advancing Biology)
H422/01 Fundamentals of biology
Time allowed: 2 hours 15 minutes
You can use:
* 2 6 6 3 9 0 2 8 8 4 *
• a scientific or graphical calculator
• a ruler (cm/mm)
* H 4 2 2 0 1 *
Please write clearly in black ink. Do not write in the barcodes.
Centre number Candidate number
First name(s)
Last name
INSTRUCTIONS
• Use black ink. You can use an HB pencil, but only for graphs and diagrams.
• Write your answer to each question in the space provided. If you need extra space use
the lined pages at the end of this booklet. The question numbers must be clearly shown.
• Answer all the questions.
• Where appropriate, your answer should be supported with working. Marks might be
given for using a correct method, even if your answer is wrong.
INFORMATION
• The total mark for this paper is 110.
• The marks for each question are shown in brackets [ ].
• Quality of extended response will be assessed in questions marked with an asterisk (*).
• This document has 40 pages.
ADVICE
• Read each question carefully before you start your answer.
© Cambridge OCR 2026 [601/4720/9] Cambridge OCR is an exempt Charity
DC (CJ/TC) 361122/4 Turn over
, 2
Section A
You should spend a maximum of 40 minutes on this section.
Write your answer for each question in the box provided.
1 Which statement about the regulation of blood glucose is correct?
A Decrease in blood glucose concentration is detected by α and β cells of the pancreas.
B Decrease in blood glucose concentration stops the secretion of insulin by α cells.
C Increase in blood glucose concentration is detected by liver cells.
D Increase in blood glucose concentration reduces uptake of glucose by liver cells.
Your answer [1]
© Cambridge OCR 2026
, 3
This is a graph showing an action potential.
40
20
A
0
B
-20
Potential
difference (mV) -40
-60
D
-80 C
0 1 2 3 4
Time (milliseconds)
Use the graph to answer questions 2 and 3.
2 What is the time taken in seconds for repolarisation to occur?
A 5 × 10–4 s
B 0.5 s
C 2.7 × 10–3 s
D 2.7 s
Your answer [1]
3 Which of the points, labelled A to D, on the graph shows where hyperpolarisation is occurring?
Your answer [1]
© Cambridge OCR 2026 Turn over
, 4
4 Neurotransmitters and ions are important in the functioning of a synapse.
Which of the following statements is/are correct?
1 Acetylcholine binds to receptors on sodium ion channels in post-synaptic membrane.
2 Calcium ions cause vesicles of acetylcholine to fuse with pre-synaptic membrane.
3 Sodium ions cause vesicles of acetylcholine to fuse with post-synaptic membrane.
A 1, 2 and 3 are correct
B Only 1 and 2 are correct
C Only 2 and 3 are correct
D Only 1 is correct
Your answer [1]
5 What treatment is not suitable for hypothermia?
A Apply warm pads to neck and chest
B Cover with blankets
C Heat hands and feet as quickly as possible
D Replace wet clothing with dry clothing
Your answer [1]
© Cambridge OCR 2026
