Please check the examination details below before entering your candidate information
Candidate surname Other names
Centre Number Candidate Number
Edexcel Level 3 GCE
Monday 11 May 2026
Mark Scheme (Final)
Morning (Time: 1 hour 30 minutes) Paper
reference 8BI0/01
Biology B
Summer 2026
Advanced Subsidiary
PAPER 1: Core Cellular Biology and Microbiology
You must have: Total Marks
Scientific calculator, HB pencil, ruler
Instructions
•• Use black ink or ball‑point pen.
Fill in the boxes at the top of this page with your name, 8BI0/01
Edexcel Advanced Subsidiary In Biology B
centre number and candidate number.
•• Answer all questions.
Answer the questions in the spaces provided
– there may be more space than you need.
Information
•• The total mark for this paper is 80.
The marks for each question are shown in brackets
– use this as a guide as to how much time to spend on each question.
• Into question(s) marked with an asterisk (*), marks will be awarded for your ability
structure your answer logically, showing how the points that you make are
related or follow on from each other where appropriate.
Advice
•• Read each question carefully before you start to answer it.
Try to answer every question.
• Check your answers if you have time at the end.
Turn over
P79080A
P:1/1/1/1/1/
Education Ltd. *P79080A0128*
, Answer ALL questions.
Edexcel and BTEC Qualifications
Some questions must be answered with a cross in a box . If you change your mind about an
DO NOT WRITE IN THIS AREA DO NOT WRITE IN THIS AREA DO NOT WRITE IN THIS AREA
DO NOT WRITE IN THIS AREA DO NOT WRITE IN THIS AREA DO NOT WRITE IN THIS AREA
answer, put a line through the box and then mark your new answer with a cross .
Edexcel and BTEC qualifications are awarded by the UK’s
1 Diabetes is a condition that causes a person’s blood sugar level to become too high. largest awarding body. We provide a wide range of qualifications
including academic, vocational, occupational and specific
Diabetes may be caused by mutations in the gene coding for insulin.
programmes for employers. For further information visit our
(a) The diagram shows the sequence of bases in part of the DNA template qualifications websites at or .
(antisense) strand coding for insulin and the mRNA molecule formed during
Alternatively, you can get in touch with us using the details on our
protein synthesis.
contact us page at
DNA template strand A T G C G C C T C
mRNA
helping people progress, everywhere
aspires to be the world’s leading learning company. Our aim is to help
(i) Complete the diagram to show the sequence of bases in this mRNA. everyone progress in their lives through education. We believe in every kind of
(1) learning, for all kinds of people, wherever they are in the world. We’ve been
involved in education for over 150 years, and by working across 70 countries, in
100 languages, we have built an international reputation for our commitment to
high standards and raising achievement through innovation in education. Find
out more about how we can help you and your students at:
(ii) Name this stage of protein synthesis.
(1)
................................ . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . ............................................................................................................................................ . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
(b) In 2019, 9.3% of the world’s population had diabetes. This was a total of
463 million people.
(i) Calculate the total number of people in the world in 2019.
Give your answer in standard form.
Summer 2026
(1) Question Paper Log Number P79080A
Publication Code 8BI0_01_2606_MS
All the material in this publication is
Answer ......................... . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
2
*P79080A0228*
, (ii) It is estimated that by 2030, 783 million people could have diabetes. General Marking Guidance
Calculate how many more people will have diabetes in 2030 than in 2019.
DO NOT WRITE IN THIS AREA DO NOT WRITE IN THIS AREA DO NOT WRITE IN THIS AREA
DO NOT WRITE IN THIS AREA DO NOT WRITE IN THIS AREA DO NOT WRITE IN THIS AREA
• All candidates must receive the same treatment. Examiners must mark the
Give your answer in standard form to three significant figures.
(1) first candidate in exactly the same way as they mark the last.
• Mark schemes should be applied positively. Candidates must be rewarded
for what they have shown they can do rather than penalised for omissions.
• Examiners should mark according to the mark scheme not according to their
perception of where the grade boundaries may lie.
• There is no ceiling on achievement. All marks on the mark scheme should be
Answer ......................... . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . used appropriately.
• All the marks on the mark scheme are designed to be awarded. Examiners
The diagram shows the base sequence in another part of the insulin gene and in
the same part with a mutation. should always award full marks if deserved, i.e. if the answer matches the
mark scheme. Examiners should also be prepared to award zero marks if the
Base sequence C T G C C C C T G C T G G C G candidate’s response is not worthy of credit according to the mark scheme.
• Where some judgement is required, mark schemes will provide the principles
Mutated sequence C T G C A C C C T G C T G G C by which marks will be awarded and exemplification may be limited.
• When examiners are in doubt regarding the application of the mark scheme
to a candidate’s response, the team leader must be consulted.
(i) State which type of mutation has taken place in this base sequence.
(1) • Crossed out work should be marked UNLESS the candidate has replaced it
with an alternative response.
................................ . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . ............................................................................................................................................ . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
(ii) Give a reason for your answer.
Use the information in the diagram to support your answer.
(1)
................................ . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . ............................................................................................................................................ . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
................................ . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . ............................................................................................................................................ . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
................................ . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . ............................................................................................................................................ . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
(Total for Question 1 = 6 marks)
3
*P79080A0328* Turn over
Candidate surname Other names
Centre Number Candidate Number
Edexcel Level 3 GCE
Monday 11 May 2026
Mark Scheme (Final)
Morning (Time: 1 hour 30 minutes) Paper
reference 8BI0/01
Biology B
Summer 2026
Advanced Subsidiary
PAPER 1: Core Cellular Biology and Microbiology
You must have: Total Marks
Scientific calculator, HB pencil, ruler
Instructions
•• Use black ink or ball‑point pen.
Fill in the boxes at the top of this page with your name, 8BI0/01
Edexcel Advanced Subsidiary In Biology B
centre number and candidate number.
•• Answer all questions.
Answer the questions in the spaces provided
– there may be more space than you need.
Information
•• The total mark for this paper is 80.
The marks for each question are shown in brackets
– use this as a guide as to how much time to spend on each question.
• Into question(s) marked with an asterisk (*), marks will be awarded for your ability
structure your answer logically, showing how the points that you make are
related or follow on from each other where appropriate.
Advice
•• Read each question carefully before you start to answer it.
Try to answer every question.
• Check your answers if you have time at the end.
Turn over
P79080A
P:1/1/1/1/1/
Education Ltd. *P79080A0128*
, Answer ALL questions.
Edexcel and BTEC Qualifications
Some questions must be answered with a cross in a box . If you change your mind about an
DO NOT WRITE IN THIS AREA DO NOT WRITE IN THIS AREA DO NOT WRITE IN THIS AREA
DO NOT WRITE IN THIS AREA DO NOT WRITE IN THIS AREA DO NOT WRITE IN THIS AREA
answer, put a line through the box and then mark your new answer with a cross .
Edexcel and BTEC qualifications are awarded by the UK’s
1 Diabetes is a condition that causes a person’s blood sugar level to become too high. largest awarding body. We provide a wide range of qualifications
including academic, vocational, occupational and specific
Diabetes may be caused by mutations in the gene coding for insulin.
programmes for employers. For further information visit our
(a) The diagram shows the sequence of bases in part of the DNA template qualifications websites at or .
(antisense) strand coding for insulin and the mRNA molecule formed during
Alternatively, you can get in touch with us using the details on our
protein synthesis.
contact us page at
DNA template strand A T G C G C C T C
mRNA
helping people progress, everywhere
aspires to be the world’s leading learning company. Our aim is to help
(i) Complete the diagram to show the sequence of bases in this mRNA. everyone progress in their lives through education. We believe in every kind of
(1) learning, for all kinds of people, wherever they are in the world. We’ve been
involved in education for over 150 years, and by working across 70 countries, in
100 languages, we have built an international reputation for our commitment to
high standards and raising achievement through innovation in education. Find
out more about how we can help you and your students at:
(ii) Name this stage of protein synthesis.
(1)
................................ . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . ............................................................................................................................................ . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
(b) In 2019, 9.3% of the world’s population had diabetes. This was a total of
463 million people.
(i) Calculate the total number of people in the world in 2019.
Give your answer in standard form.
Summer 2026
(1) Question Paper Log Number P79080A
Publication Code 8BI0_01_2606_MS
All the material in this publication is
Answer ......................... . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
2
*P79080A0228*
, (ii) It is estimated that by 2030, 783 million people could have diabetes. General Marking Guidance
Calculate how many more people will have diabetes in 2030 than in 2019.
DO NOT WRITE IN THIS AREA DO NOT WRITE IN THIS AREA DO NOT WRITE IN THIS AREA
DO NOT WRITE IN THIS AREA DO NOT WRITE IN THIS AREA DO NOT WRITE IN THIS AREA
• All candidates must receive the same treatment. Examiners must mark the
Give your answer in standard form to three significant figures.
(1) first candidate in exactly the same way as they mark the last.
• Mark schemes should be applied positively. Candidates must be rewarded
for what they have shown they can do rather than penalised for omissions.
• Examiners should mark according to the mark scheme not according to their
perception of where the grade boundaries may lie.
• There is no ceiling on achievement. All marks on the mark scheme should be
Answer ......................... . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . used appropriately.
• All the marks on the mark scheme are designed to be awarded. Examiners
The diagram shows the base sequence in another part of the insulin gene and in
the same part with a mutation. should always award full marks if deserved, i.e. if the answer matches the
mark scheme. Examiners should also be prepared to award zero marks if the
Base sequence C T G C C C C T G C T G G C G candidate’s response is not worthy of credit according to the mark scheme.
• Where some judgement is required, mark schemes will provide the principles
Mutated sequence C T G C A C C C T G C T G G C by which marks will be awarded and exemplification may be limited.
• When examiners are in doubt regarding the application of the mark scheme
to a candidate’s response, the team leader must be consulted.
(i) State which type of mutation has taken place in this base sequence.
(1) • Crossed out work should be marked UNLESS the candidate has replaced it
with an alternative response.
................................ . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . ............................................................................................................................................ . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
(ii) Give a reason for your answer.
Use the information in the diagram to support your answer.
(1)
................................ . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . ............................................................................................................................................ . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
................................ . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . ............................................................................................................................................ . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
................................ . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . ............................................................................................................................................ . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
(Total for Question 1 = 6 marks)
3
*P79080A0328* Turn over
