ECN 601 Practice Test Questions with Verified
Correct Answers
When should a peak be drawn?
After the distribution phase
-30 min to 2 hr after the end of infusion
When should a trough be drawn?
30 min prior to the next dose
What does absolute bioavailability measure?
Compares the bioavailability between an IV drug and an extravascular drug
What does relative bioavailability measure?
Compares the bioavailability of 2 dosage forms that are not IV
What describes a one-compartment model?
Distribution to all organs instantaneously
What describes a two-component model?
Distributes to the central then the peripheral
What is first-order elimination?
When a fraction of the drug eliminated per time is always the same
How is the first-order elimination graphed?
Linear paper = curved line
Semi-log paper = straight line
, How many half-lives does it take to reach 95% steady state?
4.3
What is steady state?
When the amount of drug administered equals the amount of drug eliminated
When is a loading dose used?
For drugs with a longer half-life compared to the interval (tau)
What is the difference between the elimination rate constant and the rate of
elimination?
Elimination rate constant (k): the fraction of how much drug leaves the body per unit time
Rate of elimination (RE): actual amount of drug eliminated per unit time
What explains Michaelis-Menton pharmacokinetics?
As the concentration increases, enzymes reach a point of saturation
-Dose and concentration are not proportional
How does P-glycoprotein affect drug absorption?
The greater the P-gp activity, the less a drug is absorbed
What is the salt factor?
The fraction of the administered salt form of the drug that is the active portion
What are the steps in enterohepatic recirculation?
Correct Answers
When should a peak be drawn?
After the distribution phase
-30 min to 2 hr after the end of infusion
When should a trough be drawn?
30 min prior to the next dose
What does absolute bioavailability measure?
Compares the bioavailability between an IV drug and an extravascular drug
What does relative bioavailability measure?
Compares the bioavailability of 2 dosage forms that are not IV
What describes a one-compartment model?
Distribution to all organs instantaneously
What describes a two-component model?
Distributes to the central then the peripheral
What is first-order elimination?
When a fraction of the drug eliminated per time is always the same
How is the first-order elimination graphed?
Linear paper = curved line
Semi-log paper = straight line
, How many half-lives does it take to reach 95% steady state?
4.3
What is steady state?
When the amount of drug administered equals the amount of drug eliminated
When is a loading dose used?
For drugs with a longer half-life compared to the interval (tau)
What is the difference between the elimination rate constant and the rate of
elimination?
Elimination rate constant (k): the fraction of how much drug leaves the body per unit time
Rate of elimination (RE): actual amount of drug eliminated per unit time
What explains Michaelis-Menton pharmacokinetics?
As the concentration increases, enzymes reach a point of saturation
-Dose and concentration are not proportional
How does P-glycoprotein affect drug absorption?
The greater the P-gp activity, the less a drug is absorbed
What is the salt factor?
The fraction of the administered salt form of the drug that is the active portion
What are the steps in enterohepatic recirculation?
