MLA SB A Qu estion B an k
Multiple Myeloma
50 single best answer questions — Domain 6: Conditions, Body system: Blood and Lymph
Based on the GMC Medical Licensing Assessment (MLA) content map — applicable from September 2026
,BLOOD AND LY MPH Question 1 of 50
Myeloma Myeloma: features and investigation
A 68-year-old man presents with fatigue, lower back pain, and recurrent infections. Blood tests show anaemia, hypercalcaemia, and renal
impairment. What is the most likely diagnosis?
A Multiple myeloma
B Chronic lymphocytic leukaemia
C Polycythaemia vera
D Hodgkin lymphoma
E Myelodysplastic syndrome
Select the single best answer.
,BLOOD AND LY MPH Question 1 of 50 — Answer
Myeloma Myeloma: features and investigation
A 68-year-old man presents with fatigue, lower back pain, and recurrent infections. Blood tests show anaemia, hypercalcaemia, and renal impairment. What is the most likely
diagnosis?
A Multiple myeloma ✓ Correct
B Chronic lymphocytic leukaemia
C Polycythaemia vera
D Hodgkin lymphoma
E Myelodysplastic syndrome
EXPLANATION
Multiple myeloma classically presents with the 'CRAB' features: hyperCalcaemia, Renal impairment, Anaemia, and Bone pain/lesions, alongside recurrent infections
from immune dysfunction.
, BLOOD AND LY MPH Question 2 of 50
Myeloma Myeloma: features and investigation
A 70-year-old woman with suspected myeloma undergoes serum protein electrophoresis. What finding would support this diagnosis?
A An isolated rise in albumin
B A normal electrophoresis pattern
C A complete absence of all immunoglobulins
D A monoclonal band (paraprotein), representing a single clonal immunoglobulin
E A polyclonal increase in immunoglobulins
Select the single best answer.
Multiple Myeloma
50 single best answer questions — Domain 6: Conditions, Body system: Blood and Lymph
Based on the GMC Medical Licensing Assessment (MLA) content map — applicable from September 2026
,BLOOD AND LY MPH Question 1 of 50
Myeloma Myeloma: features and investigation
A 68-year-old man presents with fatigue, lower back pain, and recurrent infections. Blood tests show anaemia, hypercalcaemia, and renal
impairment. What is the most likely diagnosis?
A Multiple myeloma
B Chronic lymphocytic leukaemia
C Polycythaemia vera
D Hodgkin lymphoma
E Myelodysplastic syndrome
Select the single best answer.
,BLOOD AND LY MPH Question 1 of 50 — Answer
Myeloma Myeloma: features and investigation
A 68-year-old man presents with fatigue, lower back pain, and recurrent infections. Blood tests show anaemia, hypercalcaemia, and renal impairment. What is the most likely
diagnosis?
A Multiple myeloma ✓ Correct
B Chronic lymphocytic leukaemia
C Polycythaemia vera
D Hodgkin lymphoma
E Myelodysplastic syndrome
EXPLANATION
Multiple myeloma classically presents with the 'CRAB' features: hyperCalcaemia, Renal impairment, Anaemia, and Bone pain/lesions, alongside recurrent infections
from immune dysfunction.
, BLOOD AND LY MPH Question 2 of 50
Myeloma Myeloma: features and investigation
A 70-year-old woman with suspected myeloma undergoes serum protein electrophoresis. What finding would support this diagnosis?
A An isolated rise in albumin
B A normal electrophoresis pattern
C A complete absence of all immunoglobulins
D A monoclonal band (paraprotein), representing a single clonal immunoglobulin
E A polyclonal increase in immunoglobulins
Select the single best answer.
