MLA SB A Qu estion B an k
Coagulation Disorders
50 single best answer questions — Domain 6: Conditions, Body system: Blood and Lymph
Based on the GMC Medical Licensing Assessment (MLA) content map — applicable from September 2026
,BLOOD AND LY MPH Question 1 of 50
Coagulation Disorders Antiphospholipid syndrome
A 30-year-old woman with a history of two second-trimester miscarriages is found to have persistently positive lupus anticoagulant and
anticardiolipin antibodies on two occasions 12 weeks apart. What is the most likely diagnosis?
A Systemic lupus erythematosus alone
B Antiphospholipid syndrome
C Von Willebrand disease
D Factor V Leiden
E Protein C deficiency
Select the single best answer.
,BLOOD AND LY MPH Question 1 of 50 — Answer
Coagulation Disorders Antiphospholipid syndrome
A 30-year-old woman with a history of two second-trimester miscarriages is found to have persistently positive lupus anticoagulant and anticardiolipin antibodies on two
occasions 12 weeks apart. What is the most likely diagnosis?
A Systemic lupus erythematosus alone
B Antiphospholipid syndrome ✓ Correct
C Von Willebrand disease
D Factor V Leiden
E Protein C deficiency
EXPLANATION
Antiphospholipid syndrome is diagnosed based on a combination of clinical criteria (vascular thrombosis or pregnancy morbidity) and laboratory criteria (persistently
positive antiphospholipid antibodies, such as lupus anticoagulant or anticardiolipin antibodies, on two occasions 12 weeks apart).
, BLOOD AND LY MPH Question 2 of 50
Coagulation Disorders Antiphospholipid syndrome
Which of the following is a recognised clinical feature of antiphospholipid syndrome?
A Recurrent venous and/or arterial thrombosis
B Bite cells on blood film
C Hypersegmented neutrophils
D Ring sideroblasts
E Isolated iron deficiency anaemia
Select the single best answer.
Coagulation Disorders
50 single best answer questions — Domain 6: Conditions, Body system: Blood and Lymph
Based on the GMC Medical Licensing Assessment (MLA) content map — applicable from September 2026
,BLOOD AND LY MPH Question 1 of 50
Coagulation Disorders Antiphospholipid syndrome
A 30-year-old woman with a history of two second-trimester miscarriages is found to have persistently positive lupus anticoagulant and
anticardiolipin antibodies on two occasions 12 weeks apart. What is the most likely diagnosis?
A Systemic lupus erythematosus alone
B Antiphospholipid syndrome
C Von Willebrand disease
D Factor V Leiden
E Protein C deficiency
Select the single best answer.
,BLOOD AND LY MPH Question 1 of 50 — Answer
Coagulation Disorders Antiphospholipid syndrome
A 30-year-old woman with a history of two second-trimester miscarriages is found to have persistently positive lupus anticoagulant and anticardiolipin antibodies on two
occasions 12 weeks apart. What is the most likely diagnosis?
A Systemic lupus erythematosus alone
B Antiphospholipid syndrome ✓ Correct
C Von Willebrand disease
D Factor V Leiden
E Protein C deficiency
EXPLANATION
Antiphospholipid syndrome is diagnosed based on a combination of clinical criteria (vascular thrombosis or pregnancy morbidity) and laboratory criteria (persistently
positive antiphospholipid antibodies, such as lupus anticoagulant or anticardiolipin antibodies, on two occasions 12 weeks apart).
, BLOOD AND LY MPH Question 2 of 50
Coagulation Disorders Antiphospholipid syndrome
Which of the following is a recognised clinical feature of antiphospholipid syndrome?
A Recurrent venous and/or arterial thrombosis
B Bite cells on blood film
C Hypersegmented neutrophils
D Ring sideroblasts
E Isolated iron deficiency anaemia
Select the single best answer.
